Excerpts

In addition, plasma CTHRC1 showed statistically significant positive correlation with RF (ρ = 0.596, p < 0.0001, Figure 5E and Table 1S ) and ACPA (ρ = 0.35, p = 0.008, Figure 5F and Table 1S ), but not with ESR, which exhibited a negative trend that did not reach statistical significance (ρ = −0.088, p = 0.512, Figure 5D ; Table 1S ).

Although the I-CRT-I group showed a trend toward reduced progression risk (HR = 0.91, 95% CI 0.68–1.22; p =0.530), no statistically significant improvement in PFS was observed compared with the CRT-I group.

By contrast, the DI group showed a trend for better ORR ( Figure 3 ) and mPFS ( Figure 5A ) than those of the PI, DnI, and PnI groups (ORRs: 47.5%, 43.2%, 33.3%, and 40.5%, respectively, p = 0.799; and mPFS: 378, 190, 170, and 172 days, respectively, p = 0.115), though the differences were not statistically significant.

T cell responses in the intake group, however, showed a trend towards higher S activated CD8 + T cell frequencies (T FH p=0.802, T H p=0.802, CD8 + p=0.235).

3.5 Modulatory effects of EcN-Scy on gut microbiota composition in mice 16S rDNA sequencing revealed that Chao, Shannon, and Sobs indices showed a decreasing trend following intervention with both EcN and EcN-Scy, indicating reduced microbial richness and evenness ( Figure 5A ).

In this study, we primarily focused our downstream analyses on associations with P< 0.003, which include both globally and nominally significant signals.

In the lungs of IIM-ILD model mice, flow cytometry identified a significant elevation in the percentage of CD19 + B cells, which showed a decreasing trend upon Nerandomilast treatment, although the high-dose Nerandomilast group did not reach statistical significance ( Figures 6C, D ).

Quantitative assessment showed a decreasing trend in CD4 + T-cell proportions and a concomitant increasing trend in CD8 + T cells in CLE, although there were no statistical significance, resulting in an overall reduction of the CD4/CD8 ratio in the CLE patients group ( Figures 5B, C ).

Such an epidemiological transition has been strongly linked to an increasing trend in obesity and established MASLD as the fastest-growing etiology leading to liver transplantation for HCC ( 1 , 2 , 29 – 31 ).

HOXC13 was associated with OS and showed a trend toward association with PFS in immunotherapy-treated LUSC, supporting HOXC13 as a candidate marker related to immunotherapy outcomes.

Conversely, for the top 11 to 100, and for the 101 to 1000 TRB counts relative to total counts, the GVHD group showed an increasing trend, although not significant ( Supplementary Figure 3b, c ).

An increasing trend was observed in the number of junctions and nodes and the total length of the network, although it did not reach statistical significance.

However, a clear trend of sexual dimorphism was observed, with female rats exhibiting generally higher baseline KNG1 expression compared to males, consistent with the proteomic dataset.

Among these, only C7_Tem_GZMB_IFN showed a decreasing trend in septic groups.

Importantly, NfL, a sensitive biomarker of axonal injury, displayed highly significant associations with these pathways ( Figure 6C ).

AE patients with poor outcomes (n=5) showed a trend toward higher median CSF titres in the acute phase and at four months post-onset compared to patients with good outcomes (n=14); however, differences were not statistically significant.

Construction of a disulfidptosis-related prognostic model From the initial 13,826 highly significant DEGs, an intersection with 103 DRGs yielded 86 pancreatic cancer-associated DRGs ( Figure 2A ).

After treatment with IS, compared to the model group, the expression level of CYP26A1 in the IS-treated group was significantly restored ( P < 0.05), and CYP39A1 expression also showed an increasing trend.

In contrast, the expression levels of OLFM1 and PTGS2 were significantly suppressed ( P < 0.05), while BCL-2 expression exhibited a decreasing trend ( Figures 7A–E ).

The IPTW-adjusted analysis confirms a strong trend favoring the CCRT+ICIs strategy at the group level.

In histological validation using LN samples, E-cadherin showed a decreasing trend across HC, NECRSwNP, and ECRSwNP, whereas N-cadherin showed an increasing trend, supporting EMT activation.

Although some such as Roseburia showed a decreasing trend in our microbiome analysis, F. prausnitzii exhibited the most significant reduction in abundance and the strongest correlation with sperm motility parameters in our cohorts.

Immunofluorescence staining provided morphological evidence for these findings: the E-cadherin fluorescence signal, which was significantly weakened and disorganized in the PM2.5+HDM group, showed a marked trend of recovery after H-151 intervention, with cellular outlines becoming clearer and more continuous ( Figure 4D ).

After adjusting for sex, age, UA, and TG, the recessive (OR* = 0.160, 95% CI*: 0.032–0.811, P * = 0.027) and codominant (OR* = 6.764, 95% CI*: 1.284–35.631, P * = 0.024) models remained significant, while the additive model approached significance (OR* = 1.692, 95% CI*: 0.991–2.889, P * = 0.054).

Second, some subgroup analyses are based on a limited number of trials, involve heterogeneous definitions and assessment methods, and in some cases demonstrate only marginally significant interaction tests.