“a marked trend”

By multivariate analysis, the clinical response to high-dose etoposide was demonstrated to have a significant impact or a marked trend toward a higher CR achievement (OR, 2.331 (1.481–3.891), P < 0.001), longer PFS (HR, 0.210 (0.069–0.643), P = 0.006), and OS (HR, 0.183 (0.062–0.543), P = 0.002).

Additionally, as the motion at the surgical level increased, there was a marked trend of decreasing LSDI scores, showing a strong negative correlation ( r = −0.802, p < 0.001) (Table 1 ).

They quantitated the LINE-1 methylation levels of each specimen by using pyrosequencing and showed that HNSCC specimens had a marked trend toward hypomethylation compared to control samples (46.8% vs. 54.0%, p < 0.001, Mann–Whitney).

The gender distribution in plenary sessions showed a marked trend, with an increasing number of female speakers (p<0.001).

Notably, the Ido1‐KO group exhibited a marked trend towards restored p‐4EBP1 ( p < 0.001) and p‐P70S6K ( p < 0.001) levels, suggesting that Ido1 KO helped maintain anabolic signalling pathways under tumour burden (Figure 3A–D ).

There was a marked trend by a graphical representation that serum neuritin levels were increased in the order of the scores from 0 to 6 ( p < 0.001; Supplementary Figure S6B ).

Participants' waists achieved reductions of 1.143 cm at 6 months for CCHO and RDC ( p = 0.02); however, at 12 months, waists began showing a marked trend, with a reduction of 1.23 cm in CCHO ( p < 0.01).

During the study period, there was a marked trend towards increased incidence for suicide (linear trend Chi square, P = 0.02) (Fig. 1 ).

A marked trend was observed, associating elevated BRI with greater risks of MACEs ( p = 0.0422) and TM ( p < 0.0001).

Detailed data on each cultivar are presented in Table S3 , showing a marked trend towards no significant differences ( p > 0.05) of percentage values from G250 to G280 fractions of all particle sizes assayed.

For overall survival, only the detection of ctDNA at baseline emerged as independent factor associated with shorter OS (HR: 2.3; 95% C.I.: 1.1–5.1, p = 0.041), while only gender had a marked trend (HR: 2.0, 95% C.I.: 1.0–4.1, p = 0.05). 4.

Interestingly, within the TB population, a marked trend to display the lowest plasma levels of IFN-γ was observed in AA carriers ( P > 0.05), in clear contrast to HD, where the opposite trend was observed ( Fig. 2b ).

In general, the percent activated T-cells was not significantly different between the groups, although there was a marked trend towards decreased activated T-cells in tumors grown in the absence of host SPARC, regardless of losartan treatment ( Figure 7A , p = 0.0507).

In the general BC group env positivity in blood was negatively correlated with age considering any group of comparison, and a marked trend towards a negative correlation with LNM (Tau-b = −0.4, p = 0.051) was observed when samples positive for MMTV in blood and tumor were compared with samples that were positive only in tumor tissue ( Table 4 ).

However, a total of six SNPs (rs4894559, rs1001793, rs3924519, rs11779484, rs4460370 and rs9314261) showed nominally significant association in different genetics models, and rs4872077 showed a marked trend under a recessive model (p = 0.052) as shown in Table 1 , hence, these seven SNPs could not be completely dismissed.

In contrast, there was a marked trend for a greater FU efficacy in mutated A1298C variants (C/C+A/C) as compared to wt homozygous cell lines (A/A) ( P =0.055 and 0.085 without and with FA supplementation, respectively).

There was a marked trend that DON feeding increases: (1) the pore number in jejunum, and (2) the number of CD16 + cells/dendrites in the epithelium (Tukey–Kramer; p = 0.055 and p = 0.067, respectively).

Of note, addition of rosuvastatin treatment to NC-diet-fed animals showed a marked trend towards a further increase in HDL APOM levels in comparison to NC diet alone ( Figure 4 C; p = 0.0556).

On the other hand, in ch.7, none of the groups showed a marked trend ( r = 0.17, p = 0.056; Real group, r = −0.20, p = 0.14; Sham group).

Univariate and Multivariate Analyses of Clinical, Pathological, and Molecular Parameters and Treatment Outcome Among the study clinical/pathological and experimental variables, univariate analysis showed statistically significant differences for PNN and KCNQ1OT1 tumor gene expression ( p = 0.011 and p = 0.002, respectively) and only a marked trend for stage ( p = 0.056) ( Table 3 ).

Since this amplicon is mostly found in P3F -positive cases, an analysis was also performed exclusively in the P3F -positive category ( n = 45) and confirmed that this amplicon is associated with a significant decrease in failure-free survival ( p = 0.042) and a marked trend toward a worse overall survival ( p = 0.056) [ 13 ].

When examining BMI as an independent variable, we observed a marked trend ( P = .06) for hip fracture patients in which the low-weight and morbidly obese cohorts have the highest mortality rates.

However, when similar analysis was done on BCER− patients, a marked trend ( p = 0.06) was found, especially evident during the first 200 days after diagnosis, suggesting that high OBR expression is associated with lower survival ( Figure 1 C).

The four-way mixed ANOVA, comprising gender (male or female) as the between-subjects factor, and the deviant type (fearful or angry), coronal site (left, midline, right) and anterior-posterior site (frontal or central) as the within-subjects factors, revealed a main effect of coronal site (left, midline, right) [ F 2,276 = 7.09, P = .001, ηp 2 = 0.049, (1-β) ≈ 100%] as well as a marked trend of deviant type (fearful vs. angry) [ F 1,138 = 3.53, P = 0.062, ηp 2 = 0.025 (1-β) = 96.43%].

While there was no difference in humanization of the moving figures between all three groups, there was a marked trend that APS evaluated the figures as being less human compared to healthy participants (“humanization”; F(2) = 2.99, p = 0.064; post-hoc Bonferroni correction: pAPS = 0.064 (see all differences in Table 3 )). 3.3.