Low-dose tofacitinib significantly extended survival of ALS mice compared to untreated control ALS mice in the intervention (6.2 day increase; p = 0.02) and cycle (7.3 day increase, p = 0.004) regimens and showed a trend towards improvement in the prevention regimen (p = 0.06; Figure 1B ).
Difference between these two subgroups was close to significance (Chi2 = 3.41, df = 1 (P = 0.06), I2 = 70.7%).
Only LV showed a trend towards significance (AUC = 0.602; p = 0.060).
While SBP and DBP did not correlate with triglyceride levels or age, we did observe a moderate, borderline significant negative correlation ( P = 0.06) between male sex and SBP but not DBP, indicating that systolic blood pressure of female CAD patients tended to be higher in our cohort.
104 mg/L, P < 0.001), translating into borderline significant superior survival ( P = 0.060 for rs1520220) and reduced treatment-related mortality ( P = 0.050 for rs978458).
Furthermore, the RNA expression of SRC was positively correlated with the protein expression (r = 0.67, p < 0.001) ( Figure 6P ), and the RNA expression of HSP90AA1 was positively correlated with the protein expression, and the statistical significance approached significant (r = 0.35, p = 0.06) ( Figure 6N ).
Results While not quite statistically significant, a higher proportion of HLA-DQA1*01:02 carriers receiving OIT in IMPACT were desensitized (93%) compared to non-carriers (78%); odds ratio (OR)=5.74 (p=0.06).
There was a nearly significant positive association between IAA and percent NK T-cells (adjusted p = 0.06) and a non-significant association of similar magnitude (based on the beta coefficient) for indole ( Figure 2B ).
Borderline significance of sTNFRSF3 (p=0.06) were demonstrated, Figure 2 .
Also, two factors, number of relapses and CRS grade, were shown to have significant relations to MRD-negative CR ( p < 0.05, Tables 2 , 3 ), while the relation between CRS grade and CR was marginally significant ( p = 0.06, Table 3 ).
Semiquantitative analysis indicated that the CD11b + macrophage population was higher in the UUO KLN than the contralateral KLN; although the comparison did not quite reach significance (p=0.06) at Day 7, a significant increase (p<0.01) was observed at Day 14 ( Figure 2B ).
Associations between NR3C1 DNA methylation and peritraumatic distress, perceived stress, and depression Results in the lower panel of Table 2 show that pregnant women who were depressed had a higher NR3C1 DNA methylation level than women who were not depressed with a marginal significance level (t = −2.13, p = 0.06).
The results showed that high expression of ALOX15 was significantly positively associated with larger tumor size (p = 0.013) and vascular invasion (p = 0.043) and correlated with advanced tumor stage with borderline significance (p = 0.060) ( Table 1 ), suggesting that ALOX15 is related to the malignant behavior of BC.
Of note, only IL-17A and IP-10 showed a trend toward a decline with p=0.06 and p=0.07 respectively, which would be worth investigating further in a larger cohort.
Among those 119 SjS patients, the titer of IgG-anti-EA antibody was inversely related to the levels of C3 (r = -0.31, P < 0.001) and C4 (r = -0.20, P = 0.03), and a marginally significant inverse correlation between IgG-anti-VCA antibody titer and C3 level was also observed (r = -0.17, P = 0.06) ( Table 2 ).
Of note, GLILD patients presented a borderline significant expansion of CD3CD8CD57+ large T granular lymphocytes ( p = 0.06), becoming significant when pooling together uILD and GLILD subgroups ( p < 0.01) ( Supplementary Table 1 ).
Increased secretion of IFN-γ and TNF-α in PMA+I stimulated MoDC approached significance (P = 0.06 and P = 0.05, respectively).
Lastly, in the differential between ANA- SLE and AHV ( Figure 2F ), TC4d (AUC: 0.75) significantly outperformed anti-Smith (0.42, p < 0.01) and nearly reached significance for superior performance against anti-dsDNA (0.51, p = 0.06) and C3 (0.50, p = 0.05).
suggested significantly greater accumulation of these cells in B6.WT mice than in B6.miR-155 −/− mice measured as a percentage of CD45 pos cells, whereas differences in numbers showed a strong trend ( p = 0.06).
ECOG scores also had a strong trend toward lowering the OS (HR, 1.9; 95% CI, 0.97-3.7; p =0.060), RFS (HR, 1.9; 95% CI, 0.99-3.8; p =0.054), and GRFS (HR, 1.7; 95% CI, 0.92-3.1; p =0.089). 3.5.
However, in the under 30-year age group, the G-allele of rs6478108 showed a strong trend toward association with T1R (OR = 2.08, p = 0.06; Table 2 ; Figure 2 ).
Notably, even patients who did not undergo transplantation showed a trend toward improved 4-year OS (21% vs. 16%, P = 0.06) ( 4 ).
TLG, included in two studies, showed a trend toward significance but fell short of the required threshold (HR = 3.68, 95% CI: 0.95–14.28, p = 0.060; I2 = 34.8%, Supplementary Figure S26B ; sensitivity analysis in Supplementary Figure S27B ).
In case of directional binary method, NLR showed a trend towards significant effect on OS with substantial heterogeneity ( Figure 4 ; HR 1.68, p = 0.06, I 2 = 59%).
Second, the retrospective design and hospital-based case selection may limit the robustness of certain findings—for instance, the association between lactation duration and PRL levels showed borderline significance (P=0.06).