Excerpts

In this small group, the mean baseline RSAD2 expression in the basophils showed a trend toward higher expression compared to the poor/non-responder group (p=0.053, Supplementary Figure S5A ).

Comparison between patients who received fewer than two DMTs prior to CLAD initiation compared to those who received two or more: a significant difference in duration until CDW during the study (borderline non-significant, p = 0.053).

However, at the 12M time point, while the SARS-CoV-2-specific CD8 + T cell frequencies were close to significance ( p =0.0534, Kruskal-Wallis test), only the CEF-specific CD8 + T cell frequencies were significantly higher than the non-specific Dextramer CD8 + T cell frequencies (p<0.0001, Kruskal-Wallis test).

More importantly, a marginally significant reduction in fold-change of lung CFUs was observed in the 12.5 μg Fc-E430G DMAb ( p=0.0535 ) when compared to Fc-WT DMAb with a significant reduction in the nasal wash in animals given 25 μg Fc-E430G ( p=0.0316 ) compared to WT-Fc ( Figures 5E, G ; Supplementary Figures S2 and S3 ).

8.5 nmol/L, p-value =0.0011, respectively), while it was borderline significant in the deceased versus survivors (2.4 vs . 4.8 nmol/L, p-value =0.0536) ( Table 4 and Figure 2 ).

The relative abundance of the remaining subclusters (C0, C1, C2, and C4) was comparable between groups and the proportion of C3 melanocytes show an increasing trend in halo nevi compared with normal nevi (p = 0.0539) ( Figure 3B ).

R0 (close margin) & R1 resection showed a trend toward higher risk of recurrence/metastasis (adjusted OR = 1.9, 95% CI: 0.99-3.64, p = 0.054), and achieving MPR showed a trend towards reduction of risk of recurrence/metastasis (adjusted OR = 0.47, 95% CI: 0.21-1.02, p = 0.057). 3.5.

In the WIV vaccination group, depletion of CD4 or CD8 T cell did not significantly alter the weight loss compared with mock depletion but a strong trend toward less weight loss was observed in mice depleted for CD4 T cells as compared to non-depleted mice of this group ( P = 0.054, Figure 6A , WIV).

On the contrary, they found that FGF21 levels were significantly higher in HIV-positive children, while we found borderline significant lower values in PLWH (p =0.054).

While WT mice demonstrated a strong trend toward induction of anti-RNP antibodies with pristane administration ( p = 0.054), this induction was further potentiated by ectonucleotidase deficiency (Figure 2 A).

Il2r (encoding CD25) ( Figure 4D ), a key receptor for IL-2 signaling in Tregs, showed downregulated levels, though the result approached significance in HuR-KO Tregs ( p = 0.054 ).

However, the serum MBL levels was barely significantly higher in men with T2D compared to women (820 μg/L (IQR 296;1767) vs. 478 μg/L (IQR 192;933), p= 0.054).

Indeed, PD1 expression within total γδ T cells in PBMC correlated positively with parasitemia from placenta tissue impression smear and placental blood parasitemia (r s = 0.305; p=0.031 and r s = 0.283; p=0.046, respectively) and borderline significance with parasitemia from a placental tissue impression smear in IVBMC (r s =0.283; p=0.054) ( Figure 3 ; Tables 2 , 3 ).

We observed a marginally significant enrichment of rare damaging missense mutations (MAF<1e-3, REVEL>0.5, Enrichment=3.6, p-value=0.054, binomial test) in the complement pathway.

Further, IL-6 concentrations showed a near-significant elevation only in t-PA-treated MCAo mice ( p = 0.054–0.067; Figure 4A ) while MCP-1 was significantly higher in t-PA-treated shams ( p < 0.05), underlying its trending rise also after MCAo ( p = 0.066; Figure 4A ).

MLs treatments raise levels of glucose, the central substrate of glycolysis and FMLs supplementation significantly increases the contents of glucose-6-P, glyceraldehyde-3-P ( p <0.05) and almost significantly increases fructose-6-P ( p =0.054) ( Figure 6 ).

In the ≥50% subgroup, the PFS improvement was of marginal significance and did not reach the statistical threshold (HR = 0.68, 95% CI: 0.47-1.01; P = 0.054).

The correlation analysis between the plasma levels of MBL and the cytokines IL-6 and TNF-α showed a trend toward a negative correlation between the levels of MBL and IL-6 ( r = -0.3553; p = 0.0540) and a trend toward a positive correlation between IL-6 and TNF-α levels ( r = 0.3419; p = 0.0644) in the group with severe COVID-19 ( Figure 3 ).

The difference in PFS between pre-NACT CD8 high and pre-NACT CD8 low patients was marginally significant ( P = 0.054) ( Table 3 ).

In the proton therapy group, blood gEUD (≥5.05 Gy(RBE) vs .<5.05 Gy(RBE)) showed a trend toward association with SRIL in univariate analysis (OR = 4.500, 95% CI: 0.972–20.827, p = 0.054).

For anti-CCP, a significant association was maintained in anti-CCP-positive patients (OR = 0.53, 95% CI: 0.28-0.98, p = 0.043), with a strong trend in anti-CCP-negative patients (OR = 0.29, p = 0.054).

coli -induced platelet aggregation from 5 890 to 3 760 AUC (36%), although not significant, a statistical trend was found (p = 0.054) ( Figure 6 ).

Similarly, we found a trending, nearly significant increase of both early apoptotic (P = 0.0549) and late apoptotic (P = 0.0547) DN T cells with QAC exposure ( Figure 6D ).

In the spleen, the number of tetramer + CD4 + T cells in CVD 1926 Δ steD -immunized mice was almost significantly different from mice that received PBS ( p = 0.055, Mann-Whitney test), with a 2.6-fold increase in the median number of cells as compared to PBS mice ( Figure 2B ).

The “ENTP6 and SMOC1” combination exhibited a negative trend with borderline significance (p = 0.055).