Excerpts

The parameter B was negatively associated with PFS, with a coefficient of -0.26 and a hazard ratio of 0.773, although the p-value was borderline significant (p< 0.05).

A correlation of borderline significance was found between FPW and age at biopsy ( r = 0.43; P = 0.05).

Non-hematological disorders showed a trend toward a better OS (77.9 vs. 62.9%; p = 0.05).

In GCA, there was a strong trend toward lower NK-cells in treatment-free remission compared to HCs ( p = 0.05).

Interestingly, the only significant predictor of inflammation as diagnosed by pathology was the tCRM score (OR: 1.90, 95% CI: 1.40–2.68, p < 0.001), while having a male donor to female recipient was protective with borderline significance (OR: 0.27, 95% CI: 0.07–0.98, p = 0.05).

The anti-VHSV antibody titer in serum demonstrated an increasing trend from 48 hpiv in the immersion group, which remained significantly ( p < 0.05) higher than that of the NVC control group throughout the immunization period, with further enhancement of the titer at 48 hpc with VHSV.

However, the HPCL samples exhibited significantly decreased levels of IL-17A (p < 0.05), IL-22 (p < 0.001), IL-23 (p < 0.01), and TGF-β (p < 0.05) with no significant change in IL-1β and a moderately significant increase in IL-6 levels (p < 0.05) compared with BVL patient group.

We also evaluated Bregs (CD19 + CD1d + CD5 + ) and found no significant difference in frequencies between the two groups, but the absolute number of Bregs approached significance in the engrafted group at day 60 post-transplant (p=0.05, Supplementary Figure 4B ).

For the differentially expressed proteins (DEPs), an adjusted p-value<0.05 (Benjamini-Hochberg) was considered statistically significant, unless stated that nominally significant proteins are shown (p-value<0.05).

Notably, we discerned three protein-MS pairs reaching marginal significance levels from the deCODE (P < 0.05 for two-sample MR analysis).

A high quotient (≥3.0) was linked to a 2.3-fold higher risk of rejection (95% CI 1.2–4.5; P =0.014) and showed a trend toward worse graft survival (HR 1.9; 95% CI 1.0–3.6; P =0.050).

In the present study, we observed that (i) the frequency of the heterozygote CT genotype at position +3422 (rs17875408) was significantly higher in cervical cancer patients than in healthy women ( P <0.05), suggesting that the +3422 C/T genotype may be a highly significant risk factor for cervical cancer; (ii) the frequency of the UTR-1/UTR-3 diplotype in patients was significantly higher than that in healthy women ( P <0.05), which may play a key role in cervical carcinogenesis; (iii) HLA-G 3’UTR polymorphic sites may influence the sHLA-G plasma level in patients’ peripheral blood, especially 14 bp Ins/Del (rs371194629) and + 3142 C/G (rs1063320); and (iii) the sHLA-G level had good diagnostic performance in differentiating patients with cervical cancer from healthy women, suggesting that sHLA-G can be a supplementary biomarker of cervical cancer.

A clear trend of decreasing of mechanical threshold and thermal latency could be observed in the endometriosis rats when compared with the sham operation group (* P < 0.05; Figures 7D, E ).

According to stratified analysis results, it was possible that female, age <40, Non-Hispanic White people, more than high school, single status, high group of PIR, owned housing, BMI≥28, smoke≥100 cigarettes in life, without hypertension, and with diabetes had lower blood eosinophil counts, with increasing serum folate concentrations displaying a significant trend (p<0.05).

Only 1/5 reports found elevated circulating CXCL9 levels in active compared to stable vitiligo patients, although the final results of studies investigating CXCL9 in blister fluid were borderline significant (P = 0.05).

Baseline IL-6 ( Table 4 , down) showed a borderline significant positive association with attention at baseline (TMT-A: β = 0.360, p = 0.050), which persisted as a trend at 5 years (β = 0.996, p = 0.052) and reached significance at 10 years (β = 0.568, p = 0.020).

A 2021 cohort study of 30 OSA patients found that 73.3% reported xerostomia, and 20% had objectively measured hyposalivation, with a clear trend of worse symptoms in moderate to severe OSA (salivary flow: 0.28 mL/min mild vs 0.14 mL/min severe; p < 0.05) ( 67 ).

Compared to the model group, the LF-EA group showed a decreasing trend in uterine mass ( P > 0.05), while the HF-EA group demonstrated reductions in uterine mass ( P < 0.05), both the LF-EA group and the HF-EA group showed a trend towards reduced uterine index, transverse diameter of the uterine horns, kidney index, and ovary index ( P > 0.05).

This result in PMN-MDSC was in contrast to M-MDSC cell numbers, where mice that were vaped and challenged with LPS had a slightly significant (p<0.05) lower levels of M-MDSC compared to mice that only received the LPS challenge.

Notably, we observed upregulation of the neutrophil extracellular trap formation pathway in Trojan dam-PI calf pairs relative to healthy dam-calf pairs, though this trend did not reach statistical significance ( p < 0.05) when comparing Trojan dams to healthy dams alone ( Figure 3D ).

Therefore, our nominally significant results (p < 0.05) require replication in larger, independent, and preferably longitudinal cohorts.

There was a trend towards the transition period being more stressful for patients who attend at least two other hospital specialists, and for those without any affected family members, but this did not reach statistical significance (fisher exact value 0.0613 in both cases, significant at p <0.05).

Additionally, the LF-EA group exhibited an increasing trend in spleen index ( P > 0.05), whereas the HF-EA group showed a significant increase in spleen index compared to the LF-EA group ( P < 0.01).

Although PNI levels showed a decreasing trend in the high-titer group, the difference was not statistically significant (P > 0.05). 3.2 Comparison of PNI, CD4 + /CD8 + ratio, and 25(OH)D levels in SLE patients stratified by anti-dsDNA titer As shown in Figure 2 , PNI, the CD4 + /CD8 + ratio, and 25(OH)D differed significantly among the three groups.

On the other hand, CGC + CD8 + T cells were not correlated with age, BMI, or waist circumference, and had a modest correlation with fasting blood glucose in non-diabetic/pre-diabetic PWH (r=0.27, p=0.009), and a trend toward significance in diabetic PWH (r=0.33, p=0.05) ( Figures 8I-L ) CGC + CD8 + T cells were also correlated with hsCRP (ρ=0.30, p =0.005) ( Figure 8M ) but not IL-4, IL-10, or IL-6 ( Figures 8N-P ).