Excerpts

A Wilcoxon matched-pairs signed-rank test demonstrated a clear trend between the paired groups of CD39 + CD8 + T cell density (two-tailed, exact P = 0.0312).

For WIF-1 gene rs3782499, PTB patients carrying the homozygous TT/CC genotype had a highly significant association with increased frequency of fever, and carrying the C allele had a lower frequency of leukopenia ( P = 0.032, P = 0.048, respectively).

Among the remaining 13 common variant candidates, only one SNP (rs3774275; MASP1 ) was nominally significant in phase II ( p = 0.0340, Table 2 ), showing the same direction of effects as in phase I.

PLEKHA1 showed a nominally significant MCI versus CN difference (T = 2.11, P = 0.036, FDR P = 0.225), and TBK1 did not reach significance ( Supplementary Table S28 ).

Results Association of Serum IL-35 With SLE and SLEDAI-2K Scores Serum IL-35 was elevated in SLE patients (median: 26.39 pg/ml; interquartile range, IQR: 22.48-34.84 pg/ml) compared with healthy controls (median: 24.85 pg/ml; IQR: 18.89-29.20 pg/ml) although with borderline significance ( p =0.038) ( Figure 2A ).

Although the analysis of relapse-free survival (RFS) in patients with HCC did not reach statistical significance, HCC patients with high TBK1 expression had significantly shorter OS (HR=1.800, P =0.038) ( Figure 2A ).

Only a marginally significant increase in anti-IMX313 antibody titers was observed on D74 for Group 2B vs. 2A (P = 0.03890, Kruskal-Wallis test with Dunn’s multiple comparison test), while no difference was evident between the groups on D84 ( Supplementary Figure 4B ).

Another IBD-associated SNV, rs17085007, showed a nominally significant association after meta-analyses, and a small effect size (p=0.039, beta=0.008).

Homozygosity for HLA-A was associated with a weak trend for greater risk of having severe respiratory symptoms (OR 1.18, 95%-CI 1.01-1.37; p=0.04, p adj =0.16).

Although asymptomatic patients had borderline significant lower IFN score than non-severe symptomatic patients (p=0.04), there was no apparent difference in IFN scores between the 2 groups of symptomatic patients (severe vs non-severe symptomatic patients) ( Figure 2C ).

The percentages of DCs in tumor did not seem to vary in NSCLC patients with different disease stages, except possibly for CD141 + DCs which were more frequent in stage I compared to stage II NSCLC, although the p -value was borderline significant ( p = 0.04) and will need to be confirmed with a larger patient cohort ( Supplementary Figure 12 ).

No significant interactions by sex or rural/urban residence were detected (p > 0.05), whereas interaction tests indicated marginal significance for age (p = 0.042) and comorbidity status (p = 0.048).

Despite this, the recently published final results of the ORACLE phase III study comparing oral 5-azacytidine to investigator’s choice in R/R AITL failed to achieve significance in the primary endpoint of PFS with a median PFS in the 5-azacytidine group of 5.6 months versus 2.8 months in the standard arm (p = 0.0421) ( 140 ).

CD3+IFNγ+ cells from RRMS patients proliferated until day 7, with a weakly significant difference observed between exposed and unexposed cells ( p =0.043).

Difference in distal femoral trabecular bone volume was marginally significant between ptx3 −/− and ptx3 +/+ males ( p = 0.0435), with lower trabecular number in ptx3 −/− mice.

Among the epidemiological factors, age had no impact on PFS (HR 0.99, 95%CI 0.978-1.003, p=0.141) but had a marginally statistically significant impact on OS (HR 0.987, 95%CI 0.975-1.00) p =0.045.

Regarding IgG, while univariate analysis showed marginal significance in CSF (P = 0.045), FDR correction rendered this non-significant (q=0.12), and no significant correlation was found with Fazekas grade (P = 0.068), suggesting limited association with WML severity in this cohort.

Likewise, the effect of higher BMI on MS after adjustment for IL-6 signaling remained, though this direct effect is considerably smaller in effect size and only borderline significant compared to the total effect obtained in the univariable analyses without adjustment for IL-6 signaling (MVMR: OR = 1.16, 95% CI =1.00-1.34, p = 0.046) ( Figure 3 ).

no-sICU/ICU HYPO group, with a borderline significant difference only for bronchiectasis (40 vs. 12.5%, p = 0.047).

Looking further downstream, we found no significant differences for the pro-inflammatory cytokines IL-6 or IL-8, only mRNA levels of MMP3, showed a borderline significant decrease at week 12 ( p = 0.047) ( Figure 2A ).

With ASVs collapsed by genus, taxon-by-taxon analysis revealed Streptococcus comprised a larger relative abundance in R than NR lesional skin (p=0.008, q=0.08) after phototherapy; this comparison approached significance in non-lesional skin (p=0.047, q=0.260).

MD2 showed a decrease in transcript level ( p = 0.031) ( Figure 2A ) and TLR2 displayed a decreasing trend ( Figure 2B ) ( p = 0.048); TLR1 and TLR3–7 showed no significant change (all p > 0.10) ( Supplementary Figure ).

However, when the C*03:03/03:04 MM pairs were omitted, the aa differences were not significant anymore, while HLA-DPB1 became borderline significant (coefficient = 1.44, p = 0.048).

Among the sepsis patients, the association between delirium and the risk for mortality was weakly significant (nondelirium vs. delirium: 9.1% vs. 47.1%, p = .049) ( Table 1 ).

Mushroom IgG responses showed borderline significance ( p = 0.049), while other antigens demonstrated no significant between-group variation ( Table 1 ).