Excerpts

A slight trend toward increased branching and average process length and volume were noted in combination-treated mice.

We only observed an increasing trend for FOXP3 expression in the L-Arg group but the result not arrive at statistical significance.

A highly significant increase in mRNA and protein levels of TGFβ receptor II (TβRII) was detected in SSc BM-MSCs as compared to healthy controls.

There was a marked trend of increased percentages of IL-10 expressing cells in the PP and MLN of WT mice compared to the Il2 −/− mice (Figures 4K,L ).

Delayed EP treatment also suppressed nitrite levels induced by LPS, and decreased Inos transcript levels with a p -value approaching significance ( Supplemental Figure 3 ).

Furthermore, we previously described a negative trend between IFNs and fatigue ( 29 ).

Combined immunization with the mixture of the fusion Xcl1-Fc protein and the free OVA SLP + CpG still resulted in a significantly better CTL expansion than in the group receiving free Xcl1 mixed with the OVA SLP + CpG, which only showed a trend for higher OVA-specific CTLs as compared to only OVA SLP + CpG.

Among the pre-Ty21a time-point, clusters 9, 11, 13, 18, and 19 are significantly more abundant in children, while only cluster 3 is significantly higher in adults (with clusters 7 and 10 trending toward significance; Figure 6B ).

( 153 ) observed a highly significant correlation between DNA derived from circulating immune complexes and disease activity index in SLE patients.

Our mouse model exhibited higher levels of anti-SSA/Ro52 and antiSSA/Ro60 antibodies in females at the age of 7 months, and higher levels of anti-SSB/La antibodies in females at 12 months of age, providing clues for a possible trend that is not easily discernable in human patients who are usually diagnosed when the disease is already established: High anti-SSA/Ro52+60 antibodies might be a trait of early disease stages, while the anti-SSB/La antibodies may have delayed elevation with respect to disease development.

activated HUVEC (ns P = 0.09) and RDES (ns P = 0.08) there is a trend toward significance.

When cells from the inguinal LN were isolated at the end of the experiment and inoculated with mBSA for 72 h to induce antigen specific T cell proliferation, re-stimulated cells derived from sCD83 treated mice showed a highly significant reduced proliferation rate upon antigen specific mBSA stimulation in a concentration dependent manner ( Figure 1H ).

However, despite this, we detected a number of highly significant differences between TB-infected and TB-uninfected individuals, and between individuals with LTBI and patients with active TB.

Further analysis with either anti-CD20- or anti-HER2-coated beads showed a trend for more rosettes and thus better binding with IgA compared to IgG, but this did not reach statistical significance ( Figures 3F,G ).

2DG, but not CG-5, showed a trend toward reduced B cell proliferation.

There was a highly significant overlap of up-regulated or down-regulated genes between poly(dA-dT) and poly(I:C) treatment groups ( Figures 2A,B ), indicating that the dsDNA and dsRNA viral infection induce common transcriptome changes.

While we did not see any difference of TNF-α, IL-15, and IFN-γ secretion between the tumor and the adjacent healthy tissue, we showed a trend with a higher production of IL-6 in tumor.

The statistical difference between Mix-MTV and GL-MTV was borderline significant ( p . 0.06) ( Figures 6A,C ).

A highly significant correlation between APRIL and IL-10 levels is observed in the synovial fluid of inflammatory arthritis patients ( Figure 8I ), suggesting that APRIL modulates IL-10 production not only in mice but also in humans.

We thus assume that ApoE KO iiself may be significant for cancer cell growth.

In this analysis, IL10 treatment resulted in a highly significant increase in Dextran uptake, when using the 1 h time point as point of comparison.

Herein, our data showed that appetite, activities and body weight changes of BCG- and rBCG-immunized mice after Mtb infection were similar to those in normal mice, and the body weight of all groups showed an increasing trend ( Figure 7A ).

While NTC siRNA had no significant effect on plasmablast generation, we were surprised to detect a strong trend in plasmablast reduction after GAPD knockdown suggesting a potential role for GAPD in plasma cell differentiation ( Figures 3D,F ).

The growth of H99-α compared to H99 was significantly suppressed at 2 dpi and showed a strong trend for reduced fungal burden at day 1.

In conclusion, even though the neutralization of IFN-γ failed to restore bacterial clearance and to significantly reduce bacterial outgrowth in the respiratory tract of co-infected mice as predicted by the mathematical model, we observed a strong trend for a potential therapeutic benefit via reducing the bacterial burden in the airways of co-infected animals.