Excerpts

Though relatively small in magnitude compared to the treatment dose [ 33 ], there is an increasing awareness that the cumulative dose may be significant, particularly in pediatric patients due to the concern for late effects and the distribution of the radiation doses [ 34 ].

For example, in patients receiving nivolumab within the CheckMate 040 trial, higher CD3+ or CD8+ T cells infiltrate in pre-treatment tumour samples showed a trend toward improved OS, and increased CD3+ correlated with objective response [ 15 ].

While the survival data for grade 1–3 ( Figure S1 ) and GBM ( Figure S2 ) show no significant difference, there was an observed trend of low sortilin levels associated with longer survival times (13 months and 1.5 months, respectively). 3.3.

In addition, hypoxanthine presented an elevated trend in the HCT group, whereas xanthine declined drastically, which was consistent with the prior metabolomics analysis of paired HCC tissues [ 12 ].

The results showed a trend towards an increase in BRCA1 expression moving from patients with a “high/high” pattern (H-score = 10) to those with a “low/low” pattern (H-score = 70).

Yes, HR = 2.55, 95% CI: 0.96–6.75, p = 0.06 (marginally significant)), and LN/distant recurrence (Yes vs.

However, study data showed a trend towards chemotherapy alone in progression free survival (11 vs. 5.8 months) and overall survival (20 vs. 13.5 months) [ 105 ].

Treatment with NVS-PAK1-1 showed a trend without obvious systemic toxicity in inhibiting NF2 [ 239 ].

Introduction Keratinocyte carcinomas (KCs) are the most prevalent form of cancer worldwide, and their incidence is rising dramatically, with an increasing trend in recent years.

SLIT2 mRNA levels in this study showed a negative trend with methylation levels of cg13281139, but were not statistically significant ( Figure S5 ).

Supporting our in vitro data, we found higher expression of HELLS in murine HCCs arising in a Trp53−/− background compared to Trp53+/+ HCCs as well as a strong and highly significant correlation between HELLS and FOXM1 expression in different HCC patient cohorts.

A study using the 45 North American Association of Central Cancer Tumor Registries demonstrated an increasing trend of NCGC incidence in younger individuals, with the trend being more pronounced in women than men [ 9 ].

Again, finally, to benchmark these observations against human GC, we correlated the expression levels of the mature miR-21-5p transcript against the recently reported functional pan-cancer “matrix remodeling” gene expression signature [ 58 ] across the stomach cancer TCGA dataset, and found a highly significant positive correlation between them ( Figure 7 C).

However, there is a clear trend that TATE is associated with a favorable outcome in many cancers, including HNSCCs [ 88 , 89 , 90 ].

However, considering all the HRD panels, there is an evident trend of higher PFS in crescent order: HRD-negative, HRD-positive, and BRCA1/2 -mutant subgroups [ 52 ]. 4.

There is an increasing trend of H. pylori -negative gastric MALT lymphoma cases, accounting for 6–40% of recent cases [ 7 , 8 , 9 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].

found only a weakly significant increase in the risk of VSCC for women reporting a history of abortion [ 79 ].

The estimates showed a trend towards an increased rate throughout the entire follow-up period ( Table 4 ).

However, patients with a high level of VISTA-expressing cancer cells (VISTA + PanCK + ) showed a trend towards worse overall survival ( Figure 3 C and Supplementary Figure S1C ).

As a result, BD was not a significant risk factor for LNM in our study despite borderline significance.

With increasing tumor size, the IL-7R level exhibited a decreasing trend ( Figure 3 E) and the CA19-9 level showed an increasing trend ( Figure 3 F).

They did not find any significant difference in ADR between both groups of endoscopists, and a nonsignificant trend was found in both HDs and LDs when CADe was used.

Excisions per year ranged from 3411 to 4749, with a clear trend towards increasing numbers of melanoma from 2014; the average number of melanoma/year prior to and following 2014 doubled (200 vs. 410).

In 2020, the second meta-analysis only focused on stages IB2 and II cervical cancers and was thus limited to 5 studies, including 2 case–control studies and only 1275 patients, with a nonsignificant trend for a 40% reduction in the risk of death with neoadjuvant chemotherapy [ 50 ].

There was a clear trend towards an increased risk of resistance in the higher risk scores of 5 and 6; however, development of MTX-R was not significantly associated with increasing risk score, and no association to histological subtype was demonstrated.