We performed the same analysis within the ICI nonresponding group and found that the cutoff of the IL-18/IL-18BP complex, free IL-18, and neutrophil concentration only showed a trend with OS, with, respectively, HR = 1.9 (IC95% = [1–3.7], p = 0.0599), HR = 1.7 (IC95% = [0.9–3.2], p = 0.1014), and HR = 1.8 (IC95% = [0.9–3.7], p = 0.94).
Detection of FRE colonization on pre-transplant testing predicted for subsequent re-hospitalization ( p = 0.002); the detection of FRE colonization, including the post-transplant samples, was of borderline significance ( p = 0.06).
High baseline seric levels of VEGF in BC patients have been found to correlate significantly with increased OS, and were of borderline significance ( p = 0.06) with improved PFS following bevacizumab treatment [ 141 ].
Hypertension without heart disease showed a trend towards increased risk with delayed surgery (HR = 2.05, p = 0.06), but this did not reach statistical significance, as shown in Table 7 .
6) showed a near-significant difference ( p = 0.06), which may become significant when increasing the number of subjects [ 94 ].
An analysis stratified by cetuximab use confirmed previous findings: the risk of not achieving pCR was 2.17 (95% CI: 1.41–3.33) in patients not treated with cetuximab compared to 0.89 (95% CI: 0.39–2.05) in patients treated with cetuximab; however, this difference was only marginally significant ( p = 0.06). 3.2.2.
The association of higher NPAD with postoperative mortality was close to significance at univariate analysis ( p = 0.06) but reached significance ( p = 0.026, OR 3.39 [1.15–9.95]) at multivariate analysis (model including age, side, ppoFEV1, CCI, and NPAD), together with right side of pneumonectomy ( p = 0.0074, OR 4.11 [1.46–11.56]) and CCI >5 ( p = 0.0011, OR 5.56 [1.99–15.54]) ( Table 5 ). 3.
A significant association was demonstrated between expression of UBC and pT status ( p = 0.0098), and a marginally significant association was observed between UBC expression and Gleason score ( p = 0.060).
Despite a clear trend in the univariable analysis, a high TMTV was not a statistically significant prognostic factor for OS in the CIT group (HR 2.2, 95%CI 1.0–4.8, p = 0.06).
did not find a low PMI to be a statistically significant independent risk factor for OS, although a statistical trend was shown (HR 1.59; 95% CI 0.98–2.59; p = 0.06) [ 35 ].
Additionally, the frequencies of group 2 cells (CD137+ IFNγ+ CD8+ T cells) were higher in cluster 3 (G) tissues compared to cluster 2 (M) tissues (marginally significant, p = 0.06).
In univariable analyses, germline variation in GZMB and PDCD1 showed a trend towards associations with OS according to the dominant model (HR 1.811, 95%CI 0.945–3.364, p = 0.060 and HR 2.027, 95%CI 0.998–4.118, p = 0.051, respectively).
Peak Bliss scores for GR-S226A cells were also lower than for wild-type NALM6 cells but with borderline significance ( p = 0.06) ( Figure 4 H and Figure S9C ).
Although only approaching significance, DGE and PPH presented a higher frequency in the PPAP population than in the no-PPAP group ( p = 0.06 and 0.08, respectively).
The presence of high endothelial venules, assessed by the MECA-79 antibody, was not associated with any of the factors studied; however, it showed a trend ( p = 0.06, χ 2 = 3.4) for a negative association with p62 nuclear expression.
A nearly significant lower presence of ctDNA DDR gene mutations was found in non-smokers compared with ever-smokers ( p = 0.06) in the 3-gene subset analysis.
We observed a statistically significant genotype-by-sex interaction for MDM4 rs4245739 ( p = 0.01) and a borderline significant interaction for rs1563828 ( p = 0.06).
Funnel plot asymmetry evaluation using the Egger’s test revealed significant asymmetry (t = 3.58; p -value < 0.002), indicating potential publication bias, while Begg’s test yielded a marginally non-significant result (z = 1.87; p -value > 0.06), suggesting weaker evidence against funnel plot symmetry (Funnel plot in Supplementary Figure S1A ).
However, among the other clinicopathological characteristics, the histological grading showed a trend toward a significant correlation to OS and DFS, with shorter OS and DFS in patients with grade 3 compared to patients with grade 1 or 2 (log-rank test p = 0.06 and p = 0.10).
In multivariate analysis, ARBs use was independently associated with decreased in-hospital mortality (OR = 0.65, 95%CI (0.44–0.97), p = 0.04) while ACEis use nearly reached significance (OR = 0.66, 95%CI (0.44–1.00), p = 0.06) ( Figure 2 , Panel B). 3.4.
ATRX gene conservation showed a favorable trend in terms of OS despite a significant result was not reached ( p = 0.06; median OS of 11 months vs. 29 months, respectively for ATRX positive vs. negative; HR 2.69, 95% CI 0.92–7.83).
Moreover, H 2 O 2 generation in DTCs showed a trend toward a correlation with extrathyroidal extension ( p = 0.06) ( Figure 3 ). 3.4.
Factors achieving significance ( p < 0.05) or showing a strong trend ( p < 0.06) incorporated in the survival score.
However, by separating the glands into two parts with the top composed of pit and isthmus and the bottom composed of neck and base, we observed an almost significant ( p = 0.06) decrease in nuclear positive cells in the neck and base of H. pylori positive tissue compared to non-infected tissue ( Figure 6 B).
In our study, pCR was an independent prognostic factor of longer DFS and almost significant for OS ( p = 0.06).