Excerpts

We found that patients with type IV exhibited the highest response rate (80%), whereas only 20% of patients with type III responded to ICT, and types I and II showed intermediate responses, with nearly significant differences ( p = 0.055; Table 4 ).

Postoperative contrast-enhancing tumor volumetry showed a trend towards longer survival for smaller postoperative volumes ( p = 0.0551).

A favorable trend for better response was found for a higher IMRT-SIB dose ≥ 55 Gy (OR 0.57; 0.32–1.01, p = 0.056).

Step 1 of the model that regressed personal control on supportive care use, holding problem-focused coping consistent across patients (the c ’ path), approached significance ( b = 0.06, se = 0.03, p = 0.056), suggesting that cancer patients scoring higher for personal control were more likely to use survivorship support programmes (see Figure 1 ).

wild-type BCOR : 18.4 months (95%-CI: 16.7–21.4), HR of LOF compared to wt BCOR = 1.409 (95%-CI: 1.010–1.965), p = 0.044), and a strong trend for reduced median OS in a multivariable analysis (HR = 1.495 (95%-CI: 0.990–2.258), p = 0.056, Figure 4 C).

Almost all the cancer cell MMP9 positive cases expressed IL-8 (18/19) on IHC, and the correlation was close to being statistically significant ( p = 0.056).

However a benefit of aRT over esRT on these long-term outcomes might exist, especially given the statistical benefit of aRT on 15-year metastasis-free survival ( p = 0.036) and the trend toward significance regarding overall survival ( p = 0.056) [ 6 ]. aRT also significantly reduces the need for subsequent androgen deprivation therapy, which is known for its inherent toxicity [ 36 ].

Kaplan–Meier survival analysis demonstrated that low RAD50 expression in the tumor center (TC) was significantly associated with worse DFS ( p = 0.016; Figure 1 A), whereas the association of RAD50 expression and OS was of borderline significance ( p = 0.056; Figure 1 B).

Regarding the direct effect of engagement on arousal, it is only marginally significant ( β = −0.16, 95% CI [−1.11, 0.01], p = 0.056).

Whether or not conization was performed before radical surgery had marginal significance for both PFS (HR 0.65, 95% confidence interval [CI] 0.41–1.01, p = 0.056) and OS (HR 0.59, 95% CI 0.34–1.02, p = 0.059).

A statistical trend was shown for shorter OS in sarcopenic patients (12.1 vs. 20.0 months; p = 0.056) ( Table 4 and Figure 4 ).

In multivariate analysis, other TP53 mutations only showed a trend of decreased PFS ( p = 0.056); however, codon 273 mutation remained a significant prognostic factor for oligodendroglioma OS in multivariate analysis (HR (95% CI): 9.05 (2.39–34.31), p = 0.001).

100.0%; p < 0.0001), whereas the DFS difference in patients presented GI bleeding was almost significant (76.3% vs. 95.6%; p = 0.0560) ( Figure 9 , Figure 10 , Figure 11 and Figure 12 ).

Margin status was near statistical significance on univariate analysis ( p = 0.056) only when considered as a gross margin, as it is typically used in nomogram prediction and was included in the multivariate analysis.

In the MMRd subgroup, LVSI showed a strong trend toward increased recurrence risk (OR 5.17, 95% CI 0.96–27.91, p = 0.056).

As for F3 , the difference was only marginally significant (paired t -test, p = 0.056; Figure 3 a).

However, data are less compelling for APL patients carrying the FLT3 -D835 mutation: RR values included values smaller than 1, and the p -value was only marginally significant ( p = 0.056).

Notably, the ICG cohort demonstrated a trend toward significance compared to the MB group, although it was not reached ( p = 0.056) ( Table 3 ).

In limited dilution assay with stem cell-enriched NSC-grown SMA-560 cells, temozolomide showed a trend ( p = 0.056) towards radio-sensitization of the cells at high irradiation doses ( Figure 5 D).

There was a borderline significant difference ( p = 0.056) in the mean age at diagnosis between the wild-type A/A genotype (54 years old) and the variant G/G genotype (61 years old) or the heterozygous A/G genotype (61 years old).

Endocrine Therapy and TSR High TSR predicted poor outcome in luminal cancers treated with endocrine therapy in OS ( p = 0.030) and was close to significance for BCSS ( p = 0.056).

The difference in the probability of EFS was almost significant between SRG and HRG (0.56 ± 0.04 vs. 0.47 ± 0.03; p = 0.0567).

Moreover, patients in the RAMSES-01 cohort showed a trend with respect to improvement of motor function (odds ratio 1.943, p = 0.057).

In the multivariate model, HER2 status (HR = 0.630, p = 0.008), menopausal status (HR = 2.362, p < 0.001), the presence of BRCA1/2 mutations (HR = 3.300, p = 0.01), axillary surgery (HR = 2.091, p = 0.003), adjuvant chemotherapy and radiation therapy (HR = 0.373, p < 0.001 and HR = 2.534, p < 0.001), higher pT and pN stages, and Ki-67 expression exceeding 20% (borderline significance, p = 0.057) remained as significant predictors of OS.

Consistently, there was a borderline significant association between % change in SSR-TV and % 53BP1 + cells at baseline ( r = 0.4215, p = 0.0570) and % change in 53BP1 + cells between BL and +24 h ( r = −0.3866, p = 0.0834) in correlation analysis.