Excerpts

This classification was more effective than HRAC alone, which could only achieve marginal significance (log-rank test = 3.7, p = 0.054; Figure 3 b), likely due to the limited size of the dataset.

The logistic regression models for the 101-gene model with three prespecified alternative IM subtype thresholds only approached significant predictive power (OR, 3.03–3.14; p = 0.054), and results were very similar with all three thresholds ( Table 3 ).

They were also more likely to choose survival length over balance between side-effects and survival as their main priority when choosing between treatment options, but this was borderline significant ( p = 0.054).

Cohort t -test evaluation showed that RT increased mean ADC significantly in three models (U87 p = 0.0121; HCT116 p = 0.0002; CT26 p = 0.0006) but only showed a trend with Calu6 ( p = 0.0545) and 4T1 ( p = 0.1003).

Additionally, a recent retrospective study in Japan on 13 individuals with T2DM on liraglutide over an 11-year study period found that the change in IPFD on CT before and after liraglutide administration decreased but narrowly missed statistical significance ( p = 0.0547) [ 70 ].

Immediate post-operative cognitive status showed an overall impairment in all domains of cognition, significant for the domains of attention ( p = 0.0273) and flexibility ( p = 0.0234) and almost significant for the domain of language ( p = 0.0547).

Of those four categories, the differences in attention (category 2) and flexibility (category 6) were the only statistically significant findings ( p = 0.0273 and p = 0.0234, respectively), while the difference in language (category 1) tended towards significance ( p = 0.0547) ( Figure 2 A–F).

Early CRCs prevalence was the highest for obese individuals (0.55%) and the lowest for overweight individuals (0.44%) with borderline significance ( p = 0.055).

Time HR-SLT was close to the margin of significance ( p = 0.055) with a trend for a higher rate of complications in the “early SLT” group.

However, the difference was marginally significant in the subgroup analysis of balanced studies (OR: 1.279, p = 0.055) and significant in the subgroup analysis of studies involving stage ≥III patients only (OR: 1.663, p = 0.005).

Grade 3/4 AEs were most frequent with ICPI plus TKI (69.1%) compared to TKI monotherapy (50.1%) and dual ICPI (32.7%), with a trend toward significance ( p = 0.055).

Univariable Cox’s proportional hazards model identified pathological grade ( p = 0.030) and N status (with a trend towards significance p = 0.055) as predictive of DFS.

When combining the discovery and validation cohorts, the PPARGC1A gene in BRCA carriers possessed more deleterious mutations than in non-carriers with borderline significance ( p = 0.055, Figure 3 b).

Patients who had greater PSA-specific T cell responses by ELISPOT also showed a trend toward longer survival ( p = 0.055), and 12/15 patients evaluated lived longer than predicted by the Halabi nomogram ( p = 0.035) [ 82 ].

3.3 mo, p = 0.02) and showed a trend for longer mOS (20.9 vs. 12.5 mo, p = 0.055) compared with those not closely matched.

Active B12 levels and TT results were nearing significance (χ 2 p = 0.055).

Furthermore, a borderline significant interaction between maintenance treatment and HDT ( p = 0.055) was observed. 2.4.

The administration of adjuvant chemotherapy was associated with worse PFS ( p = 0.013), and an unfavorable trend was also observed for DM incidence ( p = 0.055).

In the follow-up assessment, a significant trend in the final OS study was observed: 5-year OS was 73.5% vs. 62.9%, and the conclusion for the OS result was p = 0.055 [ 35 ].

Further Cox regression analyses, performed using the TCGA dataset, revealed a significant association between the gene signature and patient outcomes: four out of the five genes were independently associated with survival ( p < 0.05; hazard ratios ranging from 1.48 to 1.54), while MS4A6A showed a trend toward significance ( p = 0.055, HR = 1.4).

GGT5 expression showed a positive trend ( p = 0.055) toward a worse prognosis.

Notably, although not retained in the final models, the lesion major axis length showed a significant univariate association with VPI ( p < 0.001), while density exhibited a trend toward significance ( p = 0.055), consistent with their recognized role in pleural invasiveness.

Regarding RFS, IPI score emerged as a significant predictor of shorter RFS (HR = 1.633, p = 0.012), while response to therapy showed a strong trend toward association with RFS ( p = 0.055).

We found that patients with type IV exhibited the highest response rate (80%), whereas only 20% of patients with type III responded to ICT, and types I and II showed intermediate responses, with nearly significant differences ( p = 0.055; Table 4 ).

There was a borderline significant association between disease stage and ts-49 ( p = 0.055). 5P_tRNA-Leu-CAA-4-1 was not differentially expressed between any groups of the clinical variables. 2.4.