“an unfavorable trend”

This mutation exhibited an unfavorable trend in terms of survival (HR 7.775; P < 0.001), indicating a potentially detrimental effect on patient outcomes [ 190 ].

As shown in Supplementary Figure 2 , high scores for cluster_2 and cluster_3 were significantly associated with poorer survival outcomes (p < 0.001 and p = 0.005, respectively), while cluster_0 also demonstrated an unfavorable trend (p = 0.0031), highlighting their potential prognostic relevance. 3.4 Reconstruction of malignant epithelial cell differentiation trajectory To further investigate the transcriptional heterogeneity and differentiation dynamics of malignant epithelial cells, a pseudotime trajectory analysis was conducted.

Survival analysis demonstrated that patients in the high Met-Index group had significantly shorter overall survival (OS, log-rank p = 0.005) and also exhibited an unfavorable trend for progression-free survival (PFS, log-rank p = 0.015) compared with those in the low Met-Index group (Fig. 5 B, top).

The administration of adjuvant chemotherapy was associated with worse PFS ( p = 0.013), and an unfavorable trend was also observed for DM incidence ( p = 0.055).

Compared with one tumor lesion, two lesions were significant unfavorable prognosticator of OS (HR, 3.148; 95% CI, 1.747–5.672; p < 0.001), three lesions also showed an unfavorable trend albeit without statistical significance (HR, 2.116; 95% CI, 0.967–4.633; p = 0.061).

The overall survival rate of d-GC patients showed an unfavorable trend compared to that of i-GC patients ( P = 0.072).

The intention-to-treat analysis demonstrated a favorable trend with high-dose edoxaban (1.57% high-dose edoxaban versus 1.8% warfarin; p = 0.08) and an unfavorable trend with low-dose edoxaban (2.04% low-dose edoxaban; p = 0.10).

Although pCR rates were consistent with our current results, this study showed an unfavorable trend for CROSS compared to PF (MST 32.7 versus 16.7 months, respectively, p = 0.083).

3 , violet boxes) showed an unfavorable trend in the Southern (39% (32/82) versus 36% (20/56) in the Centre and 32% (49/151) in the Northern) (overall p = 0.098).

In the intention-to-treat analysis, there was a trend favoring edoxaban 60 mg versus warfarin (HR: 0.87 (97.5% CI: 0.73–1.04); P = 0.08) and an unfavorable trend with edoxaban 30 mg versus warfarin (HR: 1.13 (97.5% CI: 0.96–1.34); P = 0.10).

In the intention-to-treat analysis, there was a trend favoring E60 versus warfarin (HR, 0.87; 97.5% CI, 0.73 to 1.04; p=0.08) and an unfavorable trend with E30 versus warfarin (HR, 1.13; 97.5% CI, 0.96 to 1.34; p=0.10).

5 A, for the subgroup including patients with less than 15 ml of hematoma volume, in terms of 90-day renal insufficiency, intensive antihypertensive treatment showed an unfavorable trend compared with conventional antihypertensive treatment (RR = 2.00, 95% CI = 0.50–7.95, P = 0.33).

Although all countries (except Monaco) decreased their aPM 2.5 level in 2019 compared to 1990, 31 of 43 European countries had a negative PMR change and an unfavorable trend of increasing PMR in 2019 compared to 1990, thus not reducing its aPM 2.5 concentration to at least the extent of decrease in the European median.

The health sector, for instance, appears to be experiencing an unfavorable trend, a situation that has likely been exacerbated by the pandemic.

Abstract Background An unfavorable trend of increasing rates of colorectal cancer has been observed across modern societies.

In South Korea, national surveillance data show that insufficient aerobic physical activity remains common and has shown an unfavorable trend over time, underscoring the need to clarify modifiable determinants of cardiometabolic risk among older adults [ 5 ].

After PSM, this difference was no longer statistically significant ( p = 0.130), but the group still showed an unfavorable trend (HR = 1.62).

Czech healthcare is facing an unfavorable trend regarding the aging of nurses and their overall shortage in healthcare practice [ 26 ].

In China, shifts in lifestyle and economic development have contributed to an unfavorable trend in obesity rates.

In Italy, the proportion of women among all Doctoral graduates fell by over three percentage points between 2013 and 2024, an unfavorable trend that raises concern.

For progression-free interval, the high-BiScore group also showed an unfavorable trend, although the difference did not reach statistical significance ( Figure 4 D, log-rank p = 0.076).

In addition, there was an unfavorable trend in the period effect of hypertensive heart disease due to cold temperatures in North America.

However, the period effect for males shows an unfavorable trend over the period 2005-2014.

These findings would explain the opposite effect on survival when PPARγ is detected in the nucleus or in the cytoplasm: Nuclear expressed PPARγ is a prognostically favorable factor in overall survival, but detection in the cytoplasm is a prognostically unfavorable factor in disease-free survival and shows an unfavorable trend in overall survival.

4.7% placebo) also suggested an unfavorable trend toward harm, although the difference was not statistically significant.