Excerpts

In the multivariate analysis of this group of patients, only VEGF-C overexpression showed an independent impact on worse prognosis, with a borderline significance value ( p = 0.05, CI 95%: −0.03–3.99, HR: 7.2). 4.

All the associations were nominally significant ( p < 0.05) except those for the Cumulus-white MRS with the PRS for overall breast cancer and with the PRS for ER+ breast cancer.

Our findings showed a statistical trend toward higher levels of serum calprotectin in patients with inflammatory activity ( p < 0.05).

We found 92 (53 increased and 39 decreased) nominally significant DEGs of KRAS mut with a p -value < 0.05, which FREM1 , ERMP1 (up-regulated), and CCL8 (down-regulated) were significant after multiple test corrections (FDR < 0.05).

Even though these differences were not statistically significant, there was a clear trend towards a delay in the liver tumor colonization in Id1 -deficient LLC-tumor-bearing mice ( p > 0.05).

A total of 1587 SNPs showed a nominally significant association with ESCC ( p < 0.05 and 95% CI did not include OR = 1).

Experiencing TRAEs of grade 3 or higher showed a trend towards worsening OS (HR 1.79, 95% CI 1.00–3.21, p = 0.05) and PFS (HR 1.53, 95% CI 0.90–2.59, p = 0.12).

Thus, BCRP coverage decreases in the kidneys (from 67 to 58%, p < 0.05), but increases in the liver (from 33 to 49%, p < 0.001), and in the small intestine (from 42 to 51%, on the borderline of significance) and large intestine (from 39 to 52%, p < 0.05).

Patients who had not received (β = 1.05) or who completed RT (β = 1.08), showed a better SumSc score compared to those who were receiving RT, but with a borderline significance ( p = 0.05) ( Table 5 ). 4.

A constant increase in intracellular production was observed in CD3, CD3/CD4, and CD3/CD8 cells, which became highly significant already at T3d for IFNγ ( p < 0.05) and at T7d for TNFα ( p < 0.005), and increased further at later time points ( Figure 4 A,B).

SDRs due to ovarian cancer showed a decreasing trend between 2007 and 2021 (APC = −0.5%, p < 0.05).

An absence of primary osteosarcoma metastases was of borderline significance for both overall ( p = 0.050) and event-free ( p = 0.063) survival. 4.

Statistical significance is described with the following code on the figures: (ns) non-significant, (.) close to significance (between 0.08 and 0.05), (*) p < 0.05, (**) p < 0.01, (***) p < 0.001.

Additionally, most of the detected miRNAs, including the selected miR-150-5p and miR-23b-3p, did not reach the conventional significance threshold of adjusted p -values < 0.05, but they showed a trend toward significance with p < 0.05.

Statistical results were considered significant (*) or highly significant (**) at p < 0.05 and p < 0.01, respectively.

In patients with UICC stage III disease, we registered a slightly non-significant improvement in the disease-free survival (UICC III: p = 0.050).

ΔSIRI showed borderline significance ( p = 0.050).

For example, some of the variants and genes from previous NPC studies were present in our cohorts but failed to reach statistical significance ( p < 0.05), perhaps due to an insufficient sample size.

All statistical tests were two-sided, except the Jonckheere–Terpstra test, which was prespecified as one-sided to test for an increasing trend of Mel AI noma scores with higher MOLES categories; a significance level of p < 0.05 was used.

Combined features: The pairing of UCI with EV and GLMB achieved the highest performance overall, with a mean C-index of 0.80 ± 0.11 and demonstrated an extremely significant difference from other methods ( p < 0.05).

For overall survival, only the detection of ctDNA at baseline emerged as independent factor associated with shorter OS (HR: 2.3; 95% C.I.: 1.1–5.1, p = 0.041), while only gender had a marked trend (HR: 2.0, 95% C.I.: 1.0–4.1, p = 0.05). 4.

One study showed a trend toward increased risk with prior WBRT ( p = 0.05).

Among echocardiographic parameters, RVSP > 39 mmHg was a negative predictor (HR = 2.01), while RVSP < 21 mmHg and RV free wall strain < −30% were positive predictors (HR = 0.36 and HR = 0.56, respectively), whereas RV GLS < −25.5% had a borderline significance (HR = 0.59; p = 0.05).

Repeating the analyses on metabolic factors and IGF-I after further controlling for weight change, the results continued to show significant reductions in triglycerides ( p = 0.02) and IGF-I ( p = 0.03), while the reduction in total cholesterol became borderline significant ( p = 0.05).

Fatigue measured with EORTC QLQ-C15-PAL had a borderline significant effect in men (−0.33 (95%CI −0.67 to 0.03; p = 0.05)) but not in women ( p = 0.55).