Excerpts

These results establish daratumumab as the first agent to demonstrate an improvement in overall survival with a favorable trend in high-risk SMM, supporting a paradigm shift away from watchful waiting toward early intervention in this patient population.

Additionally, Kaplan–Meier analysis showed a trend toward reduced overall survival in tumors with elevated PI3K–AKT pathway activity compared with AKT-low tumors, although this did not reach statistical significance (log-rank p = 0.093; Figure 7 C).

Most cases were open (66.4%); however, there was an overall trend towards increased robotics, as only 58% of cases were open from 2020 to 2023.

Both markers demonstrated nominally significant differential expression and consistent survival associations and were therefore prioritized to construct the two-marker ICP2 signature.

sOPN showed a trend toward higher levels in advanced disease but did not reach statistical significance.

In China, the incidence of endometrial cancer is escalating, showing a significant trend towards diagnosis at younger ages [ 3 ].

The general technique of AAC preparation is well established, and pre-clinical and clinical verification of lower toxicity, higher anticancer activity, and improved stability of AAC recognizing multiple myeloma markers and delivering specific autoantigens may represent a significant trend in the upcoming years.

Several combinations involving cardiac calcification metrics and lung densitometry variables yielded highly significant models, while V37 Gy was never retained among the two best discriminative features.

A positive trend toward a decrease in breast cancer mortality is noted in the most developed countries [ 2 ].

However, a systematic Cochrane review that included two trials combining PD-1 inhibitors and five trials combining PD-L1 inhibitors, with a total of 4341 participants, demonstrated that combining checkpoint inhibitors with chemotherapy before breast cancer surgery improves pathological response, event-free survival (EFS), and overall survival (OS) in early triple-negative breast cancer (TNBC), while having marginal significance in the adjuvant setting [ 62 ].

In head and neck cancer, patients showed a trend toward better outcomes with high PD-L1 expression.

Over the past few decades, the widespread expansion of cross-sectional imaging—such as ultrasound and CT—has driven a steady increase in detected cases; as roughly 60% to 67% of RCC cases are diagnosed incidentally, a shift that has led to a notable trend toward the detection of smaller, lower-stage asymptomatic tumors [ 1 , 2 , 3 , 4 ].

A numerical trend toward longer PFS was observed among patients receiving SBRT during immunotherapy, although the differences were not statistically significant.

Additionally, the Rs-2018 regimen showed a trend towards improved survival in both EFS and OS compared with the Rs-99 regimen, particularly in the high-risk subgroup, although it did not reach statistical significance.

Instead, a descriptive analysis of the data revealed distinct trends: DPE appeared to offer a favorable trend for tumor control in extremity tumors.

The logistic regression showed a trend towards a reduced rate of postoperative complications after neoadjuvant FLOT treatment, although this was not statistically significant.

By contrast, oncogenic driver identity provided outcome-relevant biological stratification independent of age: RET fusions, NTRK1/3 fusions, and BRAF V600E were associated with significantly higher odds of a non-excellent response after adjustment, whereas RAS-mutant tumors showed a favorable trend and DICER1-mutant cases achieved excellent outcomes in the modeled cohort.

Patients with p53 wild-type tumors showed a trend toward longer PFS compared with those with p53-abnormal tumors; however, the difference did not reach statistical significance (log-rank test, p = 0.128).

In the same context, the reduction in positive surgical margins (from 27% to 22%), combined with the decline in PSA persistence over time, suggests improved tumor localization, further experience with robotic platforms, and increasing operator experience, indicating a positive trend in surgical training and education at a national level.

Moreover, this regimen showed a strong trend that approached significance in terms of median RFS (4.5 vs. 2.5 years; HR 0.85; p 0.065).

These patients have a more unfavorable prognosis, which increases the likelihood of identifying a positive trend in an effective treatment, thereby confirming the crucial role of patient selection in postsurgical strategies.

Hence, DEX may mediate the remodeling of local RAS signaling, which may be significant in overall survival and disease-free survival.

Overall, in SKOV3 cells, short-term DEX exposure tended to reduce angiotensin receptor expression, whereas prolonged treatment showed a trend toward increased expression, although these changes were not statistically significant.

In this pooled analysis, the survival benefit of ICIs was only marginally significant (HR 0.84, 95% CI 0.70–1), and no pooled results were available by cancer type.

Evidence Synthesis of AI Applications in PRO Analysis The included studies demonstrate a clear trend toward integrating structured patient-reported outcomes, unstructured clinical data, and emerging digital biomarkers, highlighting the transition to multimodal predictive oncology.