Excerpts

Compared to the nontreated control group, a significant increase in the NAC-treated group after 4 weeks was shown in Δ130-136 mice ( Figure 7 B), while such an increasing trend was not observed in NAC-treated WT mice ( Figure 7 A).

We identified 185 DMRs including highly significant differences where 82 (44%) overlapped the 5′ region of the gene and 36 (19%) where found in the promotor region.

Survival analysis showed intraepithelial TIRC7 + immune cell density to be a highly significant favorable prognosticator in intrahepatic but not proximal or distal CCA.

There was a clear trend between radiographically presumed and histopathologically verified tumor response, which did not reach statistical significance due to the small number of enrolled patients.

In addition, in several of our analyses we found only weakly significant p -values close to 0.05 before multiple-testing adjustment.

Aiming at reaffirming our findings, we evaluated its clinical significance in the institutionally-independent OVCAD multicenter validation cohort, which highlighted a strong trend between i-tRF-GlyGCC increased levels and the poor survival expectancy of the patients.

The authors also showed a trend in a higher intra-tumoral expression of MHC genes and increased inflamed tumor microenvironment under treatment.

The results showed a trend towards an increase in BRCA1 expression moving from patients with a “high/high” pattern (H-score = 10) to those with a “low/low” pattern (H-score = 70).

Yes, HR = 2.55, 95% CI: 0.96–6.75, p = 0.06 (marginally significant)), and LN/distant recurrence (Yes vs.

However, study data showed a trend towards chemotherapy alone in progression free survival (11 vs. 5.8 months) and overall survival (20 vs. 13.5 months) [ 105 ].

SLIT2 mRNA levels in this study showed a negative trend with methylation levels of cg13281139, but were not statistically significant ( Figure S5 ).

Supporting our in vitro data, we found higher expression of HELLS in murine HCCs arising in a Trp53−/− background compared to Trp53+/+ HCCs as well as a strong and highly significant correlation between HELLS and FOXM1 expression in different HCC patient cohorts.

Again, finally, to benchmark these observations against human GC, we correlated the expression levels of the mature miR-21-5p transcript against the recently reported functional pan-cancer “matrix remodeling” gene expression signature [ 58 ] across the stomach cancer TCGA dataset, and found a highly significant positive correlation between them ( Figure 7 C).

However, considering all the HRD panels, there is an evident trend of higher PFS in crescent order: HRD-negative, HRD-positive, and BRCA1/2 -mutant subgroups [ 52 ]. 4.

There is an increasing trend of H. pylori -negative gastric MALT lymphoma cases, accounting for 6–40% of recent cases [ 7 , 8 , 9 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].

found only a weakly significant increase in the risk of VSCC for women reporting a history of abortion [ 79 ].

The estimates showed a trend towards an increased rate throughout the entire follow-up period ( Table 4 ).

As a result, BD was not a significant risk factor for LNM in our study despite borderline significance.

With increasing tumor size, the IL-7R level exhibited a decreasing trend ( Figure 3 E) and the CA19-9 level showed an increasing trend ( Figure 3 F).

Excisions per year ranged from 3411 to 4749, with a clear trend towards increasing numbers of melanoma from 2014; the average number of melanoma/year prior to and following 2014 doubled (200 vs. 410).

In 2020, the second meta-analysis only focused on stages IB2 and II cervical cancers and was thus limited to 5 studies, including 2 case–control studies and only 1275 patients, with a nonsignificant trend for a 40% reduction in the risk of death with neoadjuvant chemotherapy [ 50 ].

We found that in the tumor bulk, the change in F/B is now not quite significant in either RCB group, presumably due to the lower n produced by subdividing the patients, and in the tumor/stromal interface, any change in F/B remains insignificant in either RCB group ( Figure 4 ). 3.3.

Conclusions: There was a clear trend towards adjuvant BT for stage IA G3, stage IB, and stage II G1–2 LVSI-negative EC.

The slight, but statistically significant, increase in depressive symptoms and anxiety (and the nearly significant increase for stress) observed at T1 may have been due to sensitization and prolonged exposure to the pandemic.

Among them, CTNNB1 mutational status was the only one significantly associated to a shorter RFS (HR 2.62; 95% CI 1.14–6.02), and also showed a trend towards a worse OS (HR 2.17; 95% CI 0.81–5.78).