“marginal significance”

However, after full adjustment (Model 3), only niacin retained marginal significance (OR: 0.98, 95% CI 0.97–1.00, p = 0.035).

Furthermore, a marginal significance was noted in the positive correlation between depression and lymphocyte levels (IVW beta = 0.029, p = 0.036, p FDR = 0.071).

Odor threshold (score range: 0–16) showed a non-significant correlation (r = 0.097, p = 0.101 FDR q > 0.05) and MAE of 2.58 with marginal significance (p = 0.036, FDR q = 0.054).

This result was replicated for rs3756063 in 382 patients from the Parkinson’s Progression Markers Initiative (PPMI) cohort with marginal significance (OR 1.35; one-sided p = 0.036) 47 .

Repeating the same analysis in the independent PPMI dataset for rs3756063, we replicated the same result with marginal significance (one-sided p = 0.036, odds ratio 1.35), yet strikingly similar effect size and allele frequencies across groups.

Analysis of BAT1 mRNA levels (Figure 2 ) revealed significantly elevated mRNA levels for BAT1 normalized against β-ACTIN (a) while normalization with GAPDH (b) showed marginal significance for increased BAT1 mRNA levels in the AD brains (Mann-Whitney U test: P = .037 and P = .057 respectively).

2 ), serum uric acid exhibited marginal significance (HR: 0.9970, 95% CI: 0.9942–0.9998, p = 0.037), suggesting limited clinical relevance despite statistical significance.

In contrast, marginal significance was observed for the alleles of rs948847 (P = 0.037), whereas this significance failed to survive the Bonferroni correction.

Eight other SNPs showed marginal significance: C5orf30 /rs26232 ( p = 3.73 E − 02), CCL21 /rs951005 ( p = 2.75 E − 02), GATA3 /rs2275806 ( p = 4.02 E − 02), VPS37C /rs595158 ( p = 3.10 E − 02), HLA-DRB1 /rs660895 ( p = 4.02 E − 02), EOMES /rs3806624 ( p = 3.54 E − 02), SPRED2 /rs934734 ( p = 4.24 E − 02), and RUNX1 /rs9979383 ( p = 3.48 E − 02).

Except for the interaction between Chr7 and Chr8 QTLs, that showed marginal significance ( p = 0.0378), none of the other two or three-way interactions were significant at ( p < 0.05).

Luminal A-like subtype, characterized by high-expression levels of estrogen and progesterone receptors (ER and PgR, respectively) and low ki67, showed marginal significance at the univariate logistic regression ( P = .038).

The mean WC was not different by sex or age in men and showed marginal significance by age in women (data not shown, P =0.038) ( Fig. 2 ).

There was a greater reduction regarding these parameters in the intervention group between which body fat mass reached statistical significance and weight loss presented marginal significance ( p = 0.038 and p = 0.058, respectively).

Interestingly, whereas we did not observe any significant correlation between ADTE and presence/absence of the in-frame uAUGs (Fig G ; P = 0.30, Mann–Whitney U -test; see also Fig EV5 G for ADTE calculated based on the ribosome footprinting data), we found that, for genes with proximal (≤ 100-nt upstream of the main ORF) out-of-frame uAUGs in only one allele, ADTE differed with marginal significance from that of genes with proximal out-of-frame uAUGs in both alleles (Fig G ; P = 0.038, Mann–Whitney U -test; see also Fig EV5 G for ADTE calculated based on the ribosome footprinting data).

The r g was also positive between ASB and COVID-19 (release 6) with marginal significance prior to FDR-correction but not after: r g = 0.35; P = 3.83E-02 (FDR-corrected P = 5.21E-02).

The PPD analysis revealed largely symmetrical funnel plots with no evidence of asymmetry in the BG group ( p = 0.489) and only marginal significance in the GBR group ( p = 0.039), suggesting minimal publication bias.

There are few outliers in the dataset, so we applied robust statistics as well, which resulted only in marginal significance (KW p = 0.039, DBH p adj = 0.01 for PF-ST only).

Concurrently, AFT Q4 showed reduced performance (β = −0.18, P = .012), while IRT Q4 demonstrated marginal significance (β = −0.14, P = .039).

No significant association was observed for the other seven SNPs ( P > 0.05), except for rs12440942, with a marginal significance for skin on the buttock ( P = 0.0395) ( supplementary table S4 , Supplementary Material online).

However, the marginal significance ( p -value = 0.04) limits the value of this module.

7 ( N =127), and the marginal significance reported by Caselli et al. 6 ( P =0.04) caution that previous significant findings may to an extent reflect type 1 error.

When tested against an estimated total of 12 k proteins measured, marginal significance was found (Chi-square test, one-tailed, p = 0.04).

While DOACs showed a trend toward reduced mortality (RR: 0.90, 95%CI: 0.81-0.99, p=0.04), the marginal significance and confidence intervals approaching the null value suggest a modest effect.

Finally, controlling for both gene length and expression level, the correlation between gene duplication and alternative splicing is reduced to marginal significance ( Fig. 4C ) ( P = 0.04).

Performance for middle-aged adults reached marginal significance ( Z = −2.0, p = 0.04).