“did not reach statistical significance”

Cerebral malperfusion also showed a trend toward a higher prevalence in the non-elderly group, although this difference did not reach statistical significance (6.6% vs. 2.3%, p = 0.06).

Furthermore, a correlation analysis indicated a positive trend between fecal acetate and butyrate levels (r = 0.3562), although this did not reach statistical significance ( P = 0.0805, Figure 8D ). 4 Discussion OIPN remains a critical dose-limiting side effect in diverse chemotherapy regimens, with currently limited therapeutic options ( 6 ).

In primary hepatocytes, HMOX1 expression was significantly elevated in the WD group ( p < 0.05), while DNAJB1 and GADD45B showed a trend toward upregulation that did not reach statistical significance (Fig. 3 a–c).

Interestingly, although the increase in I Ca at 12 months did not reach statistical significance in WT chromaffin cells, a clear trend was observed.

In TCGA-HNSC, CIBERSORTx-based deconvolution suggested that higher C6-like signature scores were significantly associated with worse survival, whereas higher C9-like scores showed a trend toward better survival but did not reach statistical significance (Fig. 2 h).

Although Bcl2l11 also exhibited a positive trend with mmu-miR-10a-5p and mmu-miR-24-3p, the correlation did not reach statistical significance (Supplementary Fig.

However, knowledge regarding the role of HCPs in addressing GBV, while showing a positive trend, did not reach statistical significance.

In contrast, participants who had lost a parent (i.e., child bereaved individuals) showed a trend toward increased odds of being in LC3 compared to LC1 (OR=3.77, 95% CI=0.66–21.61), although this effect did not reach statistical significance (p=0.136).

Specifically, GEBR‐7b alone showed a trend towards an increase of pTAU‐S214 that, however, did not reach statistical significance in N2a cells.

However, this finding did not reach statistical significance (p=0.06), suggesting that while there may be a positive trend, further studies with larger sample sizes are needed to establish a definitive effect.

Although the PSM analysis did not reach statistical significance for OS, a clear trend favoring the 2 g/m2 Ara-c dose was observed, suggesting a potential survival benefit with the higher dose in the CLAG regimen for R/R AML.

The TAILOR-PCI trial showed a trend towards reduced ischemic events with genotype-guided therapy versus universal clopidogrel use, although it did not reach statistical significance for the primary composite endpoint of cardiovascular death, myocardial infarction, stroke, stent thrombosis, and recurrent ischemia 186 .

However, patients showed higher systemic inflammatory activity, with elevated CRP levels, whereas ESR showed a trend toward an increase that did not reach statistical significance.

However, when accounting for the total plasma volume obtained by each method (cardiac puncture: ~0.5 mL; perfusate: ~3 mL), total particle yield per animal showed a trend toward higher recovery with perfusate blood collection in both naïve and 50 kdyne SCI groups, though these differences did not reach statistical significance ( Figure 2 c,d). 3.2.

For hs-cTnT, the association between its highest quartile (Q4) and NOAF showed a trend but did not reach statistical significance ( P = 0.056).

For food-related stimuli, the Group × Time interaction for LPP amplitude did not reach statistical significance but showed a trend in the same direction.

Different studies found that CYP3A5*3 polymorphism showed a trend of association to GC resistance in pediatric NS patients, but these associations did not reach statistical significance.

However, as shown in Figure 8 , although an increasing trend in the fibrosis index was observed in ECE-positive cases, these differences did not reach statistical significance.

DP treatment significantly restored the expression of claudin-1 and ZO-1 in FC-treated IPEC-J2 cells, whereas occludin showed an increasing trend that did not reach statistical significance ( Figure 4 A).

Compared with MTAP wild-type tumors (median 63 years, IQR 55–69), patients with MTAP deletion showed a trend toward older age; however, this difference did not reach statistical significance (Wilcoxon rank-sum test, p = 0.069).

Specifically, Dunn’s multiple comparisons test indicated that while the height loss score in the Severe group (2.700 ± 0) was numerically higher than that of the Mild group (1.667 ± 0.471), this pairwise comparison showed a strong trend but did not reach statistical significance (adjusted p = 0.0988), likely due to the conservative nature of the non-parametric test and the limited sample size in the Mild cohort.

Hospitalization duration demonstrated a positive trend but did not reach statistical significance (OR = 1.27, p = 0.065) ( Table 3 ). 4.

Neoadjuvant radiotherapy was also significantly associated with increased leakage risk (OR ≈ 3.29, 95% CI: 1.10–9.82, p ≈ 0.033), while neoadjuvant chemotherapy showed a positive trend toward higher leakage risk but did not reach statistical significance (OR ≈ 2.87, 95% CI: 0.94–8.78, p ≈ 0.064).

Tumor-related factors: Tumor ulceration and necrosis showed a trend toward worse survival but did not reach statistical significance (HR = 0.52 for absence vs. presence; 95% CI: 0.23–1.16 and p = 0.112).

A decreasing trend in MDA levels was observed in the olive oil group, whereas an increasing trend was noted in the control group; however, this difference did not reach statistical significance.