“did not reach statistical significance”

In this cohort, DLRT showed a trend towards better survival than CLSLRT in RLD patient undergoing lung retransplantation for BOS, although this did not reach statistical significance.

Co-localization of BNIP3, BNIP3L and phospho-BNIP3L with mitochondria basally showed a trend toward being reduced, however, due to large variability between both controls and patients this did not reach statistical significance ( Figure 5 and Supplementary Figure 6 ).

The length of hospital stay showed a slight increase in the risk of infection-related mortality, with an odds ratio of 1.014 (95% CI: 0.998–1.030); however, this association did not reach statistical significance (p=0.078), indicating only a trend towards significance.

For the primary endpoint of all-cause mortality or HF readmission, the NSAIDs-related group showed a trend toward improved outcomes, although the difference did not reach statistical significance (hazard ratio [HR] 0.569, 95% confidence interval [CI] 0.289–1.118; p = 0.102).

Notably, the low-dose rhCol III group (5 μg/mL) showed a trend toward reduced ROS fluorescence but did not reach statistical significance ( p = 0.0554), which may reflect a smaller effect size at low exposure, limited statistical power, and the known methodological limitations and sensitivity of commonly used fluorescent probes ( 68 , 69 ).

ACT scores showed a favorable trend in both groups, with a medium between-group effect size favoring the intervention (d = 0.42), although this did not reach statistical significance.

Concerning the intra-group analysis, although the EBWG showed a trend towards improvement in overall VAS, the difference between T0 and T2 did not reach statistical significance ( p = 0.074).

In contrast, although a decreasing trend in spheroid area was observed in the H2452 and 211H cell lines, these changes did not reach statistical significance (Figure 9 ). 4 Discussion This study demonstrated that inhibition of VPS34 by SAR405 significantly suppressed cell viability in pleural mesothelioma cell lines.

The likelihood of discussing menstrual issues with healthcare workers showed a positive trend toward better knowledge, though this association approached but did not reach statistical significance (OR = 1.7, 95% CI: 0.9–3.1, p = 0.065).

Although some markers did not reach statistical significance, SOF10 showed a trend toward suppressing TGF-β downstream targets Serpine1 , Col1a1 , and Col3a1 (Fig. 3d ).

Similarly, while CFU-E colony numbers showed a trend of increase with SRT2104 treatment (no SRT2104, 27.1%±4.7%; SRT2104, 35.7%±8.3%), this difference also did not reach statistical significance ( Fig. 4A ).

In the independent GEO cohort GSE39582 , DMBX1 expression showed a trend toward higher levels in colorectal cancer tissues compared with normal mucosa, although the difference did not reach statistical significance (Wilcoxon rank-sum test, p = 0.083).

Sarcoma showed a trend toward an increased risk; however, this association did not reach statistical significance ( P = 0.051) (Table 3 ).

Regarding emotional symptoms, we observed a decreasing trend in depressive and anxiety symptoms, although it did not reach statistical significance.

However, in the multivariate analysis, the association between ADAPT and functional outcomes did not reach statistical significance, although a near-significant trend was observed.

Aggressive ROP (A-ROP) (OR = 3.009, p = 0.106) and a history of systemic surgery (OR = 2.293, p = 0.095) showed a trend being associated with increased risk but did not reach statistical significance in this study.

Kp10 treatment showed a trend toward preventing this reduction in female neonates, though the difference did not reach statistical significance ( p = 0.0692).

Trends in Mortality In-hospital mortality showed a decreasing trend over 2009–2024 based on meta-regression analysis; however, the reduction did not reach statistical significance (β = -0.012, p = 0.055).

The NLR showed a trend toward increased mortality risk but did not reach statistical significance (adjusted HR: 1.394, 95% CI: 0.978–1.988, P=0.07).

In our study, while pSOFA scores showed a trend toward higher values in the shock group, this difference did not reach statistical significance.

In the multivariable Cox regression model, which included only variables with P<0.10 from the univariable analysis, immunochemotherapy still showed a trend towards a protective effect on DFS, although it did not reach statistical significance.

The levels of acetic acid and octanoic acid were significantly reduced in the HFD_LIG group compared with the HFD_CON group, while isobutyric acid and butyric acid exhibited a decreasing trend but did not reach statistical significance.

Group 1 showed a trend toward earlier age at symptom onset compared to the other groups, although this did not reach statistical significance ( p = 0.052).

Significant improvements were observed across nearly all domains, with the exception of managing uncontrolled high blood pressures in patients receiving TPA, which showed a trend toward improvement but did not reach statistical significance ( Table 2 ).

[ 15 , 33 , 34 ] Although between-group differences in step width did not reach statistical significance, participants with a fall history showed a trend toward larger step width values across all intervals compared to those without a fall history.