Patients in the high risk arm with large localized tumors showed a trend toward improvement with the addition of etoposide, but this trend did not reach statistical significance [ 132 , 133 ].
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In contrast, CLIC5 expression showed an increasing trend in patients with DCM but did not reach statistical significance, suggesting a less prominent role than CLIC1 and CLIC4 .
Initial SOFA scores, excluding cardiovascular components to avoid collinearity, showed an increasing trend with LV dysfunction severity, but the difference did not reach statistical significance (median 5 vs. 6 vs. 6; p = 0.066).
Survival analysis showed a trend toward poor overall survival in patients with high-grade TB but did not reach statistical significance, possibly due to the relatively small number of patients under study.
In GEP-NEN, there was a clear trend towards shorter survival in the EZH2 high group that did not reach statistical significance, possibly because the EZH2 low group was very small (n = 4).
The expansion of activated memory B cells observed at M2 negatively correlated with CD4 T-cell frequency (p = 0.022), positively correlated with CD8 T-cell activation (HLA-DR+CD38+ cells, p = 0.033), and showed a positive trend with VL that did not reach statistical significance.
In contrast, parameters such as chloride ion, apolipoprotein A1 (ApoA1), lymphocyte count, chenodeoxycholic acid (CDCA), and glycochenodeoxycholic acid showed a trend toward lower values in the GSD group, although these differences did not reach statistical significance.
Comparing the diameter of unruptured to ruptured aneurysms, we found a slight trend that did not reach statistical significance towards a greater diameter in the unruptured group compared to the ruptured group.
Although the results did not reach statistical significance, the scores for “Depression-Dejection”, and “Fatigue-Inertia” in the rosemary group showed a trend of being lower than those in the control group.
Exploratory analyses of patients with classic T1DM and severe DKA showed a trend toward shorter time to resolution, although the difference did not reach statistical significance.
Interestingly, fingolimod treatment significantly reduced total leukocyte presence at both time points; although a decreasing trend in infiltrating monocytes and granulocytes was observed, quantification of these subtypes did not reach statistical significance.
Although TSCC as a histological type (HR=1.798, 95% CI: 0.872–3.709, p =0.112) and adjuvant therapy (HR=1.863, 95% CI: 0.822–4.223, p =0.136) showed a trend toward increased risk, these associations did not reach statistical significance.
In the trabecular bone region, quantitative analysis did not reach statistical significance; however, we observed a strong trend toward a marked decrease in PDPN-positive cell numbers with ages (density of PDPN-positive cells in the trabecular bone, 0 w.o: 716 ± 93.0, 1 w.o: 217 ± 148, 2 w.o: 78.2 ± 42.7, 3 w.o: 52.6 ± 33.9, respectively, n = 3, p = 0.0552 in 0 w.o vs. 3 w.o, Kruskal-Wallis test followed by the Dunn’s multiple comparisons test, Fig. 4 E).
Although individual ASA categories did not reach statistical significance, a clear trend toward decreased survival with increasing ASA class was observed ( Table 4 ).
Compared with the control (CON) group, lambs receiving CBet supplementation exhibited increasing trends in total muscle unsaturated fatty acids (UFAs), MUFAs, and PUFAs, alongside a decreasing trend in total SFAs, although these differences did not reach statistical significance ( p > 0.05). 3.3.
a negative trendgold
We also found a negative trend between transferrin levels and indirect bilirubin levels, but this did not reach statistical significance ( b = −9.18, 95% CI −18.44 to 0.08, p = 0.052, p adj = 0.475).
Gene expression of CACNA1C (encoding the alpha-subunit of the LTCC, Figure 2 A) showed a trend, though it did not reach statistical significance, towards a reduction in miR-199a+miR-22 HL-1 cells compared to miR-NC.
Histologic examination of hematoxylin and eosin (H&E)-stained liver sections revealed a slight trend towards reduced macrosteatosis, inflammation, and nonalcoholic fatty liver disease (NAFLD) activity score, but these did not reach statistical significance ( Figure 2 J–K ).
The trabecular separation displayed a decreasing trend in the CDH-13-treated group, but the difference did not reach statistical significance ( Figure 5J ).
Analysis showed a trend in disparities between white and black or Hispanic patient 5-year survival in bone sarcomas alone; however, this did not reach statistical significance ( p -value not provided) [ 1 ].
Although our analysis did not reach statistical significance, we observed an interesting trend showing that younger women had lower methylation frequencies compared to women over 45 years old ( Figure 4 B).
It is worth noting that while elective surgery showed a trend towards worse outcomes in cirrhotic patients, this did not reach statistical significance.
Furthermore, while HUVEC overexpressing EPLIN-α showed a trend towards increased transmigration compared to knockout (KO) cells, this difference did not reach statistical significance (Fig. 6 C).
In our study, eyes with cluster PHS showed a trend of high prevalence of venous dilation and CVH, although the differences did not reach statistical significance.
Fluorescence imaging revealed an elevated trend in hepatocyte apoptosis within the 2,4-D group compared to control animals, although this difference did not reach statistical significance ( p > 0.05).