Excerpts

We found that the expression of IL2RG, used by all common gamma chain cytokines, exhibited a highly significant upregulation pattern in SIV compared to control ( p = 0.000045), and in SIV/Meth compared to SIV ( p = 0.0001).

For the plastic bag-samples, a highly significant difference between the reference material and the two obtained samples (plastic bag-metal and plastic bag-no metal) was observed (1-way ANOVA, F = 12.9, p = 4.5 × 10 −5 ), while the means of the two plastic samples showed no significant difference (post-ANOVA Tukey-test, p adjusted = 0.11).

There was thus a highly significant association between flight performance in the cage and outside (Fishers exact test: two-tailed P = 0.0000452).

Apart from immunity and defense ( P = 5.84×10 −11 ), other highly significant biological processes highlighted include chemokine and chemokine-mediated signaling ( P = 4.53×10 −5 Table 3 ).

Variants at PHLPP1 were also nominally significant in the independent meta‐analysis of African individuals that included WGS data ( p = 4.56 × 10 ‐5 ).

The P-value is highly significant when corrected for multiplicity (207 sites, Bonferroni corrected P-value = 4.6e-5).

Linear regression with parameters as predictors was highly significant, but accounted for a far smaller amount of variance than the synthetic data (adjusted r 2 = 0.36, p = 4.6E-5).

The results are shown in Figure 2 , with the probability of belonging to the Dent and the Flint groups for each parental line (Figure 2 A) and the highly significant correlation ( P value = 4.6 × 10 -5 ) observed between the GWRR in a population and the average 'flintness' of its parents (Figure 2 B).

In this database, only one SNP (rs331142) in the ROBO1 gene showed a trend for association to ROBO1 expression ( p = 4.6 × 10 −5 ), but it did not reach genome-wide statistical significance (Tran et al. 2014 ).

Crude rates in PMRT were 22.5% for prepectoral reconstruction (25/111), 62.9% for submuscular DTI (22/35), and 39.1% for expanders (9/23), with a highly significant overall difference (global χ 2 p = 4.61 × 10− 5 ).

Further examination of the tumor tissue sections after anti-PD-1 therapy revealed the co-localization of mast cells and FOXP3 + Treg cells, which was consistently observed and highly significant ( p = 0.000047) when compared to control-treated tumors (Fig. 4e ) and this may be associated with downmodulation of HLA class I on tumor cells (Fig. 3g, h, f ).

The difference in this increase in nuclear enrichment upon exercise between HITT and TRAD was 1.89 and highly significant ( P = 4.7 × 10 −5 ; Fig. 6 C , SI Appendix, Fig.

50 synonymous), and highly significant G -test results ( G = 15.20, P = 0.000048).

Migraine showed modestly significant genetic correlations (Bonferroni-corrected P < 4.8 × 10 − 5 ) with chronic pain duration and susceptibility ( r g > |0.5 | ).

Using a logistic regression on the model ln(w ij /(1−w ij )) = a+b ln(P i P j ) , we observe a highly significant negative correlation between confirmation probability w ij and log-transformed popularities of the interaction partners ( a = −1.41±0.04; b = −0.020±0.005, p = 4.8*10 −5 ; N = 62,864 statements).

These analyses demonstrated for example a clearly significant enrichment for ESRRA binding motifs (∼2-fold, P = 4.8E-5) ( Supplementary Data Sheet 1 ), suggesting that the transactivation activity of ESRRA may depend on the DNA methylation status of its binding motif.

There was a highly significant effect of regions (linear mixed model, P = 0.000049).

By that time, decreases in cell counts were still highly significant ( P = 0.000049 and P = 0.00006 for CD3 + and CD3 + CD4 + , respectively).

Meta-analysis of the 2 cohorts yielded highly significant evidence of association with JIA (OR 0.76 [95% CI 0.62–0.88], P = 4.9 × 10 −5 ).

As expected, we observe stronger average absolute correlation in the ISO-treated cohort ( R = 0.174 vs 0.111), and that while the control cohort’s correlations of the adrenergic signalling pathways with Serpina3n were not significantly higher than expected ( p = 0.728), the correlation of Serpina3n expression with the ISO cohort was highly significant ( p = 4.9 × 10 −5 ).

Myc knock-down had a highly significant effect on the extent of glial dedifferention (one-way ANOVA, F (3,13)=18.99, p =4.94×10 −5 ).

Differences were highly significant at 3 hours among all groups ( P <0.00005).

There were two SNPs in the serum IgG analysis, one SNP in the total protein analysis, four SNPs in the globulin analysis, four SNPs in the ZST analysis, one SNP in the specific gravity analysis and three SNPs in the crude illness analysis, which approached significance ( P < 5 × 10 −5 ) (Table 3 ).

This revealed a highly significant correlation (r = 0.80, p<0.00005; Appendix 2—figure 1D ).

The results presented in Table 3 showed a highly significant ( p value = 0.00005, detection limit of the method being approximately 1 log CFU, CI-95%, 1.85, 2.77) log reduction (2.31) in microbial load after wiping the meat surface with the developed DW (count before treatment—5.48 log CFU/cm 2 ; after treatment—3.17 CFU/cm 2 ).