Excerpts

The Pearson correlation coefficients of the genome size to the decay rate were highly significant ( cor = 0.684, p = 4e-5) and were comparable to the growth rate ( cor = 0.772, p = 6e-7).

This difference in proportions is highly significant ( P < 4E-5, Fisher’s exact test, two-sided).

However, a highly significant, strong direct association was expressed between BMI and adiponectin in the controls before intervention (r = 0.83, p = 0.00004).

Results The proportion of mothers not breastfeeding at four months of age showed a highly significant trend across the neighbourhood strata (p = 0.00004): from 16.3% (< 10% with low purchasing power) to 29.4% (≥ 30% with low purchasing power), yielding an OR of 2.24 (95% confidence interval: 1.45-3.16).

The comparison of the frequency of AML specific mutations in the PDX panel and data of an AML patient population from TCGA revealed a highly significant correlation of both data sets (Pearson correlation coefficient 0.81, p < 0.00004).

A highly significant difference was detected in hemoglobin levels among GSD1b patients (Wilcoxon signed-rank test, V = 253, p -value ≈ 4.028e−05).

Last, we evaluated the evidence for 14 previously published aneurysm risk single‐nucleotide polymorphisms through collaboration in extended aneurysm cohorts, with a total of 6548 cases and 16 843 controls (IA) and 4391 cases and 37 904 controls (AAA), and found nominally significant associations for IA risk locus 18q11 near RBBP8 to AAA (odds ratio [OR]=1.11; P =4.1×10 −5 ) and for TAA risk locus 15q21 near FBN1 to AAA (OR=1.07; P =1.1×10 −3 ).

Consistent with these opposite changes in rates, there was a highly significant drop in the correlation of events in the two networks ( n = 9 brain slices; pre‐cut R 2 range = 0.83–0.98; post‐cut R 2 range = 0.33–0.58; P = 4.1 × 10 −5 ; Wilcoxon rank sum test).

There was a total of 16 variants of the GTF2F2 region that produced a highly significant signal ( P = 4.1 × 10 -5 - 5.28 × 10 -6 ), whereas the two variants of KCTD4 were not associated with NCP 4 ( P = 0.02 - 0.03).

Importantly, a comparison of 38 cancer cell lines found a highly significant correlation between high integrin β3 gene copy number and neratinib (Pearson correlation coefficients: 0.614, p -value = 4.12 × 10 −5 ) or lapatinib (Pearson correlation coefficients: 0.436, p -value = 1.13 × 10 −2 ) resistance ( Figure 2 E).

When these datasets were combined in our statistical model (see methods), differences between apical and basal dendrites were highly significant ( p = 4.14e-05, Additional file 5 , Fig. 4 g).

Gene set enrichment analyses demonstrated nominally significant enrichment in the set related to collagen type XI trimer ( P = 4.18 × 10 −5 ) (Table S7 ).

Another correlated SNP in the same region (rs269101, r 2 = 0.42 in 1000 genomes phase3 Finnish individuals) showed a trend toward association in our GWAS ( p = 4.2 × 10 −5 ) and in the replicate ( p = 0.054), further supporting the result.

Other highly significant pathways with a positive z-score were related to dendritic cell function and neuroinflammation, namely dendritic cell maturation (−log( p -value) = 4.37, z-score = 1.00) and neuroinflammation signalling pathway (−log( p -value) = 3.71, z-score = 2.00). 3.4.

We confirm the previously published association of the lead variant in the total sample, with the association for DBP still being highly significant in the UKB data alone ( P = 4.27 × 10 −5 ; N = 423,655).

Notably, overweight and obese Persians reported a significant trend towards dietary restraint following weight gain compared to Arabs ( P = 4.29 × 10 −5 ), with AMY1 CN showing negative association with dietary self-restraint ( P = 3.22 × 10 −3 ).

However, if 50 replicates were meta-analyzed, PRKCA became significant in the Asian sample ( N = 16,050, p = 3.4 × 10 −11 ) and in the Yoruba sample ( N = 5,600, p = 5.6 × 10 −9 ) and was trending toward significance in the Luhya sample ( N = 5,400, p = 4.3 × 10 −5 ).

For falling number, a nearly significant region was found on chromosome 7B ( p -value = 4.3 * 10 −5 ) with an allele frequency of 89% for the advantageous allele (Figure 5D ).

The moderate and highly significant positive correlation between Mcl-1 and USP9x immunoreactivity (Spearman’s r = 0.560, p = 0.000043; Pearson’s r = 0.510, p = 0.00025) proposed an interrelation between the anti-apoptotic protein Mcl-1 and the deubiquitylating enzyme USP9x in prostate cancer. 3.2.

This difference was also evident in the AFR populations from the UK Biobank and AASK, where both variants are common and show moderate, nominally significant effects after adjusting for G1/G2 ( p = 4.4 × 10 −5 and 4.5 × 10 −5 , respectively, Figure 4 B; Table 2 ).

1a ) was also highly significant ( P = 4.4 × 10 − 5 ).

In the combined study and after correcting for multiple testing, there was a highly significant association of C4A copy number with AMD ( P = 4.4 × 10 −5 , P corrected = 1.3 × 10 −4 , Fig. 2 ).

The intergroup difference for this finding was statistically highly significant (p = 0.000044).

The full regression model was highly significant ( R 2 = 0.45, f (6,48) = 6.5, p = 4.43 × 10 −5 , robust multiple linear regression; for variation inflation factors see Supplementary Fig. 2 ).

We also re-ran the model, including average mean diffusion in the TBSS-derived skeleton as an additional predictor, which had minor effects on the results, reducing the p-value for atrophy slightly (0.031), while retrieval activity was still highly significant ( p = 4.46 e −5 ) and R 2 (adjusted) = 0.237.