Excerpts

Moreover we were able to detect 184 adipogenic candidate genes (85 with increased, 99 with decreased expression) that were differentially expressed during adipogenic development of MSC and/or between MSC and fat tissue in a highly significant way (p < 0.00001).

In addition, although the acute EtOH response of CE and CS group mice was measured at different stages of the study, on day 3 in CE and day 11 in CS, the genetic correlation was highly significant ( r = 0.92, p < 0.00001).

Although, individually, 5 studies data did not reach statistical significance [ 63 , 80 , 87 , 88 , 99 ], the overall effect showed the reduction of CRP levels after supplementation (MD: −1.10, 95% CI: −1.26, −0.93, p < 0.00001, Figure 13 ).

This revealed a total of 52 out of 176 neurofeedback runs that achieved high regulation (~30%; median per participant: 2; MAD: 1.7; range: 0–6), which was highly significant according to binomial testing ( P < 0.00001) (Fig. 2C ).

5 C, D indicated that the correlation between estimated and ground-truth EC was highly significant ( p < 1e-5) for low NSR (NSR < 0.3) and remained significant ( p < 0.005) even for large NSR (NSR ≥ 0.3).

The analysis of 3,538 TADs revealed that 472 contained p-RCAs and 677 contained i-RCAs, of which 278 contained p-RCAs and i-RCAs within the same TAD, a highly significant association ( χ 2 = 557; p < 0.00001).

All differences were statistically highly significant ( p < .00001).

There was a very highly significant negative correlation between the seatbelt compliance and road traffic death rates (R = - 0.77, F = 65.5, p < 0.00001).

The relative amino acid composition of FFS and LFS varied in accordance with DoF and the relationship was found to be highly significant (ANOVA, p < 0.00001).

However, the improvements in sleep were highly significant in Group A in the 2 nd week of drug intake ( P = 0.00001) [ Table 3 ].

Results remained highly significant when excluding the cross-fostered bats ( n = 11), which were only tested in year 3 ( P < 0.00001; learning : 0.19±17 vs. 0.45 ±0.19 error rates, respectively, R 2 =0.72, p < 0.00001, mixed GLM with learning set as the response variable, the origin as a fixed factor and the bat’s ID as a random effect, n = 65).

Results The results revealed highly significant changes (p-value <0.00001) in the levels of CEA (56.698±44.558 ng/mL), ENO1 (51.784±10.395 ng/mL), AFP (116.275±38.956 ng/mL), and CP (287.425±33.181 ng/mL) in the cancerous group compared to the control group, suggesting their potential utility in early diagnosis.

This segregation is highly significant (p < 0.00001 for the Mann-Whitney U test) confirming distinct patterns of strain neutralization specific to the eliciting virus.

The YAPS, BLSA, and ROS proteomic signatures, including 86, 254, and 244 significantly altered proteins, respectively, share 25 proteins, and this intersection, defined as the incipient AD proteomic signature, is highly significant (SuperExactTest, P < 0.00001).

Pooled data from 13 distinct datasets (10 unique studies), including 415 FGR cases and 561 controls, demonstrated a marked and highly significant prolongation of left ventricular isovolumetric relaxation time (LVIRT) in FGR fetuses compared with controls (SMD, 2.48 (95% CI, 1.55–3.41); P < 0.00001; I 2 = 97%) (Figure 3d ).

The deviation from Hardy-Weinberg equilibrium is highly significant ( P < 10 −5 , Fisher’s Exact Test 40 ) with a complete absence of heterozygotes.

This test showed a highly significant size difference between the spermathecae within a female, suggesting that across timepoints, there is one smaller and one larger spermatheca ( P < 0.00001).

Comparison between the groups showed a highly significant difference in anxiety score reduction, with the compliant group demonstrating greater improvement (p<0.00001) Table 2 .

We established a baseline frequency of stable aberrations that showed a highly significant curvilinear increase with age (p < 0.00001) that accounted for 70% of the variance among donors.

The calculation of associations based on various models, based on [ Table 2 ], showed the most significant associations of iPNP, which imply a specific relationship between genotype and phenotype, including statistically highly significant differences in genotypic, additive (trend), general recessive and dominant models also for the placental function gene APOC3 (rs5128, G5163C) ( P < 0.00001).

The conversion rate was 2.53% ( n = 133/5263) in the robotic and 11.94% ( n = 3874/32,442) in the laparoscopic group, and was highly significant to the favor of the robotic group ( p < 0.00001). 4.

Interestingly, only three AD risk variants exhibited genome‐wide ( p < 5 × 10 −8 ) significance or a level approaching significance ( p < 1 × 10 −5 ) with baseline memory performance, including rs429358 ( APOE , p = 2.03 × 10 −33 ), rs6733839 ( BIN1 , p = 3.96 × 10 −7 ), and rs4844610 ( CR1 , p = 8.43 × 10 −6 ).

Not only that, the comprehensive effects revealed that the TC changes relative to baseline further became an extremely significant difference in both groups [MD = 3.34; 95% CI (1.88, 4.79); P < 0.00001].

A three within-subjects RAnova (type of score × block × ear) showed a highly significant type of score effect, [ F (1.7,103) = 235, p < 0.00001, η p = 0.80, ω 2 = 0.22], with greater phonemes scores than word scores; block effect [ F (1,59) = 13, p < 0.00001, η p = 0.19, ω 2 = 0.022] with greater scores for the second block ( Figure 2A ), but no overall significant ear effect [ F (1,59) = 2.2, p = ns].

In the ACS patients, the bleeding rate showed a highly significant difference between the short DAPT vs . standard DAPT, with a risk ratio 0.59 (95% CI 0.47-0.74; z=4.56, p=0.00001) (Fig. 4A ).