Excerpts

Statistical analysis using the Kruskal–Wallis test revealed a highly significant overall difference among the groups ( p = 3 × 10 −6 ).

p21 prevalence differed significantly between most nevus and melanoma categories, and the overall trend with progression was highly significant ( r = 0.528, P = 3 × 10 −6 ; Table 1 ).

A combined LDS-gene burden analysis was performed, revealing a highly significant association (4.5% vs 1.5%; p=0.000003).

Parameters are statistically highly significant ( r = 0.9712 and p = 0.000003) while analysis of residual distribution shows a good agreement with the normal distribution (Shapiro-Wilk test, W = 0.9608, p = 0.7952).

Analysing this group against the remaining groups combined was highly significant ( P =0.000003) ( Figure 4d ) and was an independent prognostic factor ( P =0.0003, HR=0.1, 95% CI=0.0–0.4) ( Table 2 ).

Nominally significant associations were observed for the following health risk factors: Telomere length was longer among girls compared to boys (p = 3 e–06) and among children of high affluence families (p=0.008).

First, we found SYT1 as a near-significant ( P = 3 × 10 − 6 ) top sweep candidate in the YRI population, featuring both m ^ = 2 sweeping haplotypes and m ^ = 2 MLGs involved in the sweep at the window of maximum signal for K = 20 ( fig. 5 and supplementary fig.

This difference is highly significant ( t = 5.1, p = 3×10 −6 ).

Conversely, the recA generalized linear model showed little difference to the null model ( p -value = 0.93), whereas that of pstS showed a highly significant difference ( p -value = 3.08×10 −6 ) from the null model ( Figure 4 ).

The correlation between phenotypic and carbapenemase genes detection was highly significant for K. pneumonia, E. coli, P. aerugnosa and A. baumannii ( P = 0.0000031; P = 0.00079; P = 0.015; P = 0.02, respectively) while for ESBL genes correlation was only significant for P. aerugnosa ( P = 0.038) Table 3 .

When correlating with pathological biomarkers, the SI showed strong correlations with all the measurements ( P ≤ 3.2e−6), with the weakest correlation observed for diffuse plaque, which was still highly significant ( P = 3.2e−6) ( Fig. 2C ).

After adjustment for age, sex, smoking status, use of antihypertensive medications, and HDL-C levels with the Bonferroni correction, participants carrying the minor alleles of the rs2043085 and rs1532085 genotypes exhibited a significant trend of higher LAP ( P = 3.2 × 10 −6 and 8.1 × 10 −6 for rs2043085 and rs1532085, respectively) and VAI ( P = 4.3 × 10 −6 and 5.2 × 10 −6 for rs2043085 and rs1532085, respectively).

This overlap of DMRs between replicated experiments is highly significant ( P -value = 3.3 × 10 −6 ).

To assess this possibility, we compared delta divergence from the consensus between neighboring ERVs (|neighbor_1_div—neighbor_2_div|) in ERV hotspots to other regions of the genome and report a significant trend in the opposite direction (Mann Whitney U, P = 3.317e−06), suggesting that SD is not the primary contributing mechanism to ERV hotspot formation.

There were about 146/275 (53%) of the CPC-1 up- and downregulated genes under amino acid starvation exhibiting rhythmicity, indicating a highly significant enrichment of CPC-1 regulated genes as clock-controlled genes (p = 3.341905e−06, hypergeometric distribution test).

In addition, CpG06500161 was also significantly associated ( P = 1.60 × 10 −9 ) with HOMA-IR, while CpG1881899, also a CpG site in ABCG1 , was marginally significant for that phenotype ( P = 3.36 × 10 −6 ).

Multivariate SD–gene interaction analysis in participants of african descent In the Yale-Penn participants of African descent, we observed the HGF gene survived Bonferroni multiple testing correction for the StructLMM interaction test ( p = 1.08 × 10 −6 ) and approached significance in the association test ( p = 3.39 × 10 −6 ).

The overall joint test of the SSTR5 haplotypes on presence of acromegaly (comparing acromegaly patients and control II group) was highly significant ( P =3.4×10 −6 ).

Using Fisher's exact test, the association between claudin-4 and CA125 positivity was shown to be highly significant (P = 3.4 × 10 -6 ), confirming the lack of independence between these two markers.

The correlation remained highly significant in most cohorts of each cancer type ( R = 0.73, P = 3.4 e‐06) (Fig. 2E and Fig.

The genome-wide analysis of TNE with CPD exhibited reduced marginal significance ( p -values < 3.4E-6), reduced numbers of variants in the chr15q25.1 and chr19q13.2 regions, and a different region with the most variants selected (chr10q25.3).

Following variable selection including only those significantly contributing to the class difference the multivariate difference between Groups was highly significant (p = 3.5 ∗ 10 − 6 ).

Mediation analysis evidenced a highly significant direct effect of total HA experience on LE (with more than 1 point increase in EEAS per log(years in HA experience) (1.051 (SE = 0.227), z = 4.6, p = 3.5 × 10 −6 ), a significant but weaker indirect effect mediated by better ear hearing threshold (0.216, (SE = 0.072), z = 3, p = .003 ) that represented only 17% of the effect seen (total effect estimate: (1.267 (SE = 0.22), z = 5.73, p = 10 −8 ).

The correlation between RDW and AML risk remained highly significant when controls without ARCH-PD were excluded from the analysis (P=3.5 x 10 -06 , Wald test with Bonferroni multiple testing correction, Extended Data Fig. 5b ).

Variants in locus 6q24.3-q25.1 reached marginal significance (rs9390543, SASH1 , P = 3.56 × 10 –6 , OR 0.75) in CCSS and significance when meta-analyzing with SJLIFE ( P = 2.02 × 10 –8 , OR 0.75).