Excerpts

The extremely significant difference ( P = 2.6964E-08) between them suggests the specificity of these genes to distinguish the diabetic PDAC patients from the non-diabetic cases ( Figure 4 ).

Quantitative analysis evidenced a highly significant MEK5 6.2-fold increase (p=2.7×10 −8 ) and ERK5 5.5-fold increase (p=2.2×10 −9 ) in tumoral samples when compared to normal tissue ( figure 1j ).

5c ), and a paired t -test of the chromosome-level percentages was highly significant ( P = 2.722 × 10 −8 ).

The regression models reflect highly significant correlation values (Ras: R 2 = 0.78, P = 2.74E-08; RasGEF: R 2 = 0.35, P = 2.78E-03; RasGAP: R 2 = 0.38, P = 1.67E-03; RapGAP: R 2 = 0.38, P = 1.68E-03).

When the analysis was stratified by gender, one additional SNP (rs549485) located about 350 kb apart from the SAA1 subregion at 11p14 in the secretion regulating guanine nucleotide exchange factor ( SERGEF ) gene showed a borderline significant association with A-SAA levels in men (p = 2.76×10 −8 ) in the meta-analysis.

Comparing the full set of 1377 differentially expressed genes to those contained within the gene ontology term “central nervous system myelination” (accession number GO:0022010), we found highly significant enrichment of myelination-related genes (Fisher’s exact test, odds ratio = 3.66, p -value = 2.76×10 −8 ).

Strong and highly significant positive correlations were observed bilaterally between MMSE scores and GMV in the hippocampus (Right: R = 0.542, p = 2.83e-08; Left: R = 0.517, p = 1.59e-07), amygdala (Right: R = 0.48, p = 1.47e-06; Left: R = 0.403, p = 7.38e-05), and parahippocampal gyrus (Right: R = 0.45, p = 7.59e-06; Left: R = 0.407, p = 6.18e-05).

We observed a nominally significant finding (p = 2.9E-08, λ = 1.027 - corrected p gc = 2.2E-07, λ = 1.0015) on chromosome 6q21 in the gene coding for the non-receptor protein-tyrosine kinase, Fyn.

Protein-coding regions displayed 11.29-fold enrichment, 5’ UTR regions achieved 8.00-fold enrichment, while extended intronic regions showed 1.32-fold enrichment at extremely significant levels ( P = 2.92 × 10 –8 ), suggesting that these regions may participate in complex genetic mechanisms through regulation of gene expression or function.

Patient-derived OPCs exhibited a size distribution that was strongly shifted toward smaller cells, a finding that was highly significant across all patient and control lines (Kolmogorov–Smirnov D = 0.25, P = 3.0 × 10 −8 ; Fig. 3d ).

While no individual epistatic association was genome-wide significant (p< 2.56e-10), several approached significance (p< 3e-8).

MYO7A and PDZD7 were not only highly enriched, but the enrichment was highly significant statistically (p=3 × 10 –8 and p=2 × 10 –5 ).

The difference in the proportions of left and right flexions between the lumbar and cervical LHS groups was highly significant (Fisher’s Exact Test, two-tailed: p = 3 × 10 −8 ). 4.

The risk allele G of rs7535263 was also more frequent in cases (allele frequency, 64 of 104 [62%]) of cohort 2 compared with controls (allele frequency, 1451 of 2584 [56%]) but did not reach statistical significance, most likely representing an underpowered comparison (combined meta-analysis (OR, 0.58; 95% CI, 0.38-0.77; P = 3.0 × 10 −8 ) ( Figure 4 ).

The omnibus test of hazard across the quartiles of Lp-PLA 2 activity was highly significant ( p = 3 × 10 −8 ).

Such a difference would be highly significant for independent species (Kolmogorov–Smirnov test, p < 3 ∗ 10 -8 ).

In the sub-Saharan African sample, both the MAF and the DAF spectra showed a highly significant increase in the proportion of singletons with respect to the proportion expected under a constant population size model (χ 2 P = 3×10 −8 and χ 2 P = 9×10 −5 , respectively).

Analysis of variance indicated a highly significant genotype effect for both traits (p = 3.02 × 10 − 8 for LD; p = 2.04 × 10 − 4 for Survival%).

Also, for the women-only primary analysis, the rs77186623 in LOC105375745 locus associated with HIPadjBMI (β = −0.006, P = 1.74 × 10 −7 ) exhibited nominally significant interaction by background group ( I 2 = 55.3%, P diff = 0.042) and was GWS in the Caribbean group ( N = 3231, MAF = 0.041, β = −0.0078, P = 3.05 × 10 −8 ) but not significant in the mainland group ( N = 4216, MAF = 0.008, β = −0.0015, P = 0.567, Supplementary Material, Table S7 ).

For the RNA-seq Diet, we again found a highly significant overlap with 52% of up-regulated genes in Suv420h dKO overlapping with PPAR-γ targets (odds ratio, 1.6; 95% CI, 1.37 to 1.93; Fisher P = 3.1 × 10 −8 ).

Here, we report a highly significant association with a variant (rs75652600, P = 3.12 × 10 −8 , odds ratios = 4.34) within a zinc finger gene, ZNF592 , from an imputation-based fine-mapping study of the chromosomal region 15q25 in African-Americans with neurosarcoidosis.

Statistical tests confirmed the highly significant differences in genetic diversity between subgroups Ia and Ib ( Z test p = 3.19 × 10 −8 ; T test p = 4.27 × 10 −8 ), and between phylogroups I and II ( Z test p = 1.64 × 10 −6 ; T test p = 1.04 × 10 −5 ).

This signal was driven by cases with and without extrarenal manifestations, since the burden difference was still highly significant when analyzing cases without extrarenal defects separately ( P = 3.21 × 10 −8 ; Figure 1A – B and Supplementary Figures 3 and 4 ).

Exposure of cells to ox-LDL resulted in a moderate increase in enhancer histone signals flanking this CRE (Figure 6 A) and highly significant increases in both the chromatin accessibility of this CRE ( P =3.3×10 −8 ) and MITF expression (average log2FC=0.39; P <2.2×10 −16 ).

However, when father’s age and mother’s age were entered jointly in a multiple regression, father’s age remained highly significant ( P = 3.3×10 −8 ), but not mother’s age ( P = 0.49).