Excerpts

abortus S99 sLPS) was tested and shown to be highly significant ( p = 0.00000002).

Single-marker and pairwise interaction analysis using LR Single-marker analysis showed highly significant disease association with rs2476601 ( p = 2 × 10 -8 ), and nominally significant effects for rs237025 ( p = 0.003) and CT60 ( p = 0.038) in both the median-replaced and the imputed data sets (see Figure 2a and 2c ).

The probability of obtaining male versus female pups from fl/fl-Cre or wt/fl-Cre females was highly significant (P<2 × 10 −8 ).

8b , right), where the slope of the fit decreases by more than half in the resting as compared to the running state across all combinations of N t and L , yielding a highly significant difference (two-tailed, paired t -test; p = 2e − 8, t = 9.2, df = 19).

Sixty-eight genes had a direct association through co-occurrence, which is a highly significant over-representation ( p = 2.04 × 10 -8 ) given the number of genes associated with this concept in the predefined concept set "Genes".

Interestingly, this correlation remains highly significant (R = 0.98 & p = 2.1 × 10 −8 ), when considering data from the United States (i.e., 44,488 taxa in 24,930,000 km 2 from 2,200,000 records; [ 8 ]).

Regression analysis (see Methods) showed that this association is highly significant (Fig. 3f , p = 2.1e−08, R 2 = 0.51, n = 30).

The linear relationship remained highly significant even after removing any combination of one ( p < 2.10 × 10 −8 ) or two neurons ( p < 3.34 × 10 −5 ), indicating that the observed effect was not driven by a small subset of cells.

In the meta-analysis, the rs3020789 showed a genome-wide significant association and a nominally significant association for the male group ( β = –0.020; P = 2.12 × 10 −8 ) and female group ( β = –0.012; P = 0.024).

The effect of INH + STR resistance on THD in L2.2.1 isolates was also highly significant when incorporating multidimensional scaling (MDS) components as covariates in linear regression ( P = 2.14 × 10 −8 ), suggesting that substructure within the L2.2.1 sublineage was not driving the association.

One marker (rs885036, position 98671226) on chromosome 2q12 showed a highly significant interaction with treatment arm (P = 2.17x10 -8 ).

When an interactive linear model was again considered, the result was also highly significant both for the high-status group (β-estimate = −37.4445, t = −5.60, p = 2.18 × 10 −8 ; model Adj.

We found a highly significant tendency between different tumor tissue types (one-way ANOVA, P =2.20×10 −8 , FDR=8.95×10 −7 ) ( Table 5 ).

We observed a highly significant difference in Wolbachia density between species at the female (W = 11, P = 2.21 × 10−8), L1 (W = 30, P = 4.07 × 10−7), L2 (t = −9.54, P = 5.19 × 10−11), L3 (W = 18, P = 2.01 × 10−7), and L4 (t = −3.35, P = 0.0017) stages, with Cx. quinquefasciatus consistently showing higher densities than Cx. pipiens molestus .

These increases are highly significant, having scores of χ 2 = 16.72 ( p = 2.3E -8 ) and χ 2 = 72.5 ( p = 1.6E -17 ) to S. nigrimanum and S. vittatum , respectively.

We found some correlation between the contig N50 values and the number of NUMT regions (Spearman’s correlation, ρ = 0.60, p = 0.002) and a highly significant correlation between the contig N50 and the number of NUMT sequences, as well as the total size of NUMT sequences (Spearman’s correlations: ρ = 0.88, p = 2.3E−8; and ρ = 0.9, p = 5.47E−9, respectively).

Both changes were highly significant (student’s t-test, p<2.3900e-8 for rHIgM22 vs isotype control; p = 0.0000 for PDGF/FGF-2 vs isotype control).

We demonstrate a highly significant association between the NR2F2 loss-of-function mutations and this syndromic form of DSD (p = 2.44 × 10 −8 ).

Fish that underwent Partial isolation (Pi), exhibited an intermediate, yet highly significant, change in social preference ( Figure 1A , right panel: C vs Pi, p=2.5e −8 , Mann-Whitney).

Logistic regression analysis identified operative time as a highly significant independent predictor of flap loss ( p = 2.5 × 10 −8 ).

The frequency of APOE ε4 carriers increased progressively across the clinical spectrum, from CN individuals (25%) to those with MCI (53%) and AD (71%), with a highly significant group effect ( p = 2.5 × 10 −8 ). 3.1.

While variance in BMI differed significantly between PRS groups (Levene’s test p = 0.015), the PRS effect remained highly significant when accounting for heterogeneity (Welch’s ANOVA F = 21.0, p = 2.5 × 10 −8 ).

The average AUC improvement was statistically significant ( p -value = 2.1 × 10 −6 ), and the MCC comparison also showed a highly significant difference ( p -value = 2.5 × 10 −8 ).

A highly significant interaction was seen between time and age (p = 2.6e-08).

Previous GWAS did not uncover an association between rs17810398 and age-related macular degeneration, but when analyses were stratified by sex, the association was highly significant for females ( p = 2.6 × 10 −8 ) and not males ( p = 0.382) [ 25 ].