Excerpts

The results showed highly significant improvements for our method compared with both 3D morphological dilation ( P -value = 3.3882E—8) and 3D anisotropic distance transform ( P -value = 3.3882E—8).

In fingolimod-treated patients, the decrease in BAFF-R expression was highly significant in all evaluated B cell subsets (1.77 x 10 -5 ≤ P ≤ 3.42 x 10 -8 ) and most manifest in terms of effect size on transitional B cells ( Figures 2A–D ).

Time points 1 and 2 show a slightly increased level of additive genetic variation relative to later time points that is highly significant (Wilcoxon, p = 3.48×10 −8 ).

To confirm the association of signature scores with tumor stages (Ta, T1, T2, T3, and T4), we observed a notable distribution of mean scores across T‐stages (Figure 4B ), with an increasing trend from early to advanced stages ( p = 3.5E‐08).

The same markers at MITF on CFA20 and USH2A on CFA38 were detected as marginally significant when both herding and non-herding breeds were analyzed together ( P = 3.5 x 10 −8 and P = 3.6 x 10 −8 , respectively).

6 and 7 a highly significant, strong correlation (Spearman’s rho = 0.81, P < 3.5 × 10 −8 ) between the total number of stem cell divisions in an organ and the lifetime risk in that organ was reported.

The presence in ticks of Anaplasmataceae bacteria as a whole exhibited highly significant variations in relation to temperature ( P = 3.544e-08) and relative humidity ( P = 1.02e-06), being more abundant at higher temperatures and lower relative humidity, as typical during the summer season ( Supplementary Table S1 ).

However, we found that EFEMP1 expression in GTEx human thyroid tissue was positively correlated with the risk alleles of one of the 2p16.1 BA-associated SNPs, and that this correlation was highly significant (rs1346786, GTEx eQTL P = 3.6 × 10 −8 ).

The genetic contributions of LOF variants in our cohort with TAA remained highly significant when compared with the rates extracted from gnomAD (OR, 3.78 [95% CI, 2.35–6.06], P =3.6×10 −8 ), with no enrichment detected in individuals without TAA versus gnomAD (OR, 1.44 [95% CI, 0.86–2.40], P =0.16).

1.12 × 10 6 CFU/mL, MW p = 8.60 × 10 −4 ) and in combination with lysozyme and lactoferrin decreased biofilm viability, and these results were highly significant (1.05 × 10 5 CFU/mL vs. 1.12 × 10 6 CFU/mL, MW p = 3.60 × 10 −8 ).

Here, we expect 70 genes and find 118- the actual number of genes in the overlap exceeds that expected by chance and was highly significant (p = 3.6 -8 , binomial test).

The expression difference between normal and tumor samples was highly significant ( P = 3.6 × 10 −8 ). 3 ́ RACE analyses confirmed the annotated 3 ́-end and revealed another, less abundant isoform with a non-annotated 3 ́-end (Figure 2C ).

We found a highly significant correlation between the microarray and the RT-PCR gene expression quantification (Pearson correlation coefficients r = 0.89, P = 3.6e−8 and r = 0.65 P = 0.0009 for CTLA4 and TIMELESS , respectively) (Supplementary Figure 5 ).

Examining all 424 variants, there was a highly significant correlation (Spearman’s rank test) between the CD and IBD case/control replication p values ( p = 3.7 × 10 − 8 ) but not between CD and UC ( p = 0.234) or UC and IBD ( p = 0.094).

The multiple comparison of normal mucosa versus CRC tumour tissue versus CRC cell lines resulted in highly significant p-values for all four ratios of circRNA/linRNA (circ0817/CUL5: p = 3.7e-08; circ3204/USP3: p = 6.4e-10; circ6229/METTL3: p = 2.2e-09; circ7374/TNS4: p = 1.7e-05).

When excluding the patients with structural heart disease from the analysis, a highly significant association for AGXT2 rs16899974 was observed with any AF (P = 3.9 × 10 −8 ), and with paroxysmal AF (P = 3.0 × 10 −5 ) and chronic AF (P = 7.0 × 10 −4 ) separately.

Gene enrichment analysis was performed with the ToppGene Suite [ 27 ], and showed a highly significant enrichment (hypergeometric P = 4 × 10 -8 ) for 18 genes annotated to the set of 222 genes known to be up-regulated in CD133 + relative to CD133 - hematopoietic stem cells in the 'Jaatinen_HSC_Dn' Molecular Signatures Database (MSigDB) [ 28 ] entry.

There was a strong and highly significant difference in copy number (estimated from the qRTPCR) among the groups identified by TaqMan and ddPCR (ANOVA: F 4,38 = 18.4, P = 4 × 10 −8 ) with a progressive increase from a single-copy average for susceptible homozygotes (Gn), suggesting that all or most are unduplicated, to resistant homozygotes (Sn) which averaged in excess of four gene copies (Fig. 6 ).

The overall association between haplotypes and triglyceride levels was highly significant (p < 4 × 10 -8 ).

A comparison of the partially spliced transcripts identified by LRS to our nRNA-seq data showed a highly significant overlap between data sets ( P -value = 4 × 10 −8 , Fisher's exact test) ( Supplemental Fig.

As expected, T1 COGAVG was highly significant in all models ( p < 4.0 × 10 −8 ), although none of the models showed a significant effect of YEARS, age, sex, or disease course.

There was low between-study heterogeneity ( I 2 =32·8%: p =0·13), and the overall association of short sleep with diabetes risk was highly significant (OR=1·33 [95%CI: 1·20, 1·48); p =4x10 -8 ), with no evidence of publication bias (Egger’s test p =0·15).

This SNP was in linkage disequilibrium with two other SNPs that were nominally significant rs78201023 (MAF = 0.0393, p = 4.01 × 10 −8 , D ’ = 0.897) and rs77512118 (MAF = 0.0372, p = 1.37 × 10 −6 , D ’ = 0.908).

Chi‐square analysis confirmed a highly significant difference among groups ( χ 2 (2, N = 42) = 59.19; p = 4.03 × 10 −8 ).

The results show that TPSA is quite significant ( p -value = 4.1 × 10 − 8 ).