Excerpts

Additionally all mutants showed a trend toward steeper slopes than WT, but only the augmentation slope in dlgA mutants reached statistical significance ( Fig. 5 D).

Cells were defined as PI + if the PI fluorescence increased drastically between two frames or if the initial basal fluorescence signal was increased by more than 5% and demonstrated an increasing trend in subsequent time-lapse images until equilibrium was achieved.

All results were either significant or of marginal significance.

A p-value less than 0.05 and 0.01 was considered statistically significant and highly significant, respectively.

Figure 7A shows that the knockdown of LmMet results in significantly decreased transcript levels of the chymotrypsin genes, LmChy1, LmChy2 (MWW; p < 0.01), while transcript levels of LmChy4 show a strong trend in the same direction.

However, a decreasing trend (−12 m) was observed in typical BMD, hinting at a possible detection of significant changes with longer observation, and supporting the clinical meaningfulness of longitudinal 6MWT in BMD.

However, the statistical tests conducted at the second in vivo time point showed a trend towards changes in the diffusivity metrics (MD and RD) in the corpus callosum.

CMIP5 MMM clearly suggests significant warming by the end of the 21 st century (+0.0073 ± 0.0115 °C a −1 in the RCP2.6 scenario and + 0.0296 ± 0.0200 °C a −1 in the RCP8.5 scenario) and only a slightly increasing trend in precipitation (+0.51 ± 1.35 mm a −1 for RCP2.6 scenario and +1.92 ± 1.86 mm a −1 for RCP8.5 scenario) over the Kerguelen.

The CCT showed an increasing trend at postoperative 1 week and then returned to preoperative levels at postoperative 12 months.

For most of the ROIs, the genetic correlations between the homologous regions were found to be highly significant and also the test of genetic correlations r G = 1 tenable.

In this context, it is possibly significant that MscS can tolerate additions to the carboxy-terminus (e.g. the alkaline phosphatase protein), and the 18 residues at the carboxy-terminus can be deleted without significantly impacting folding, assembly or function 20 .

There was a significant trend over the quartiles and a compelling gradient of increased prevalence of cognitive impairment for levels of Lp-PLA 2 .

In both the case of ABT-263 and cisplatin, we observed highly heterogeneous responses to the drug treatments, illustrating the need for population level analyses as completed here when analyzing the effects of drugs on mitochondrial morphology, as such heterogeneity may be significant in determining overall tumor response to treatment.

Further, ERα in TS was the only marker that served as an independent prognostic factor for PCD (HR: 0.28, 95% CI: 0.1–0.78, p = 0.015) along with Gleason grade ≥ 9 and PNI, although aromatase in TE tended towards significance.

The changes in CD68+ macrophages and Ki-67+ cells showed an increasing trend going from uninfected to SIVnoE to SIVE animals, but were only significant for CD68+ macrophages between uninfected and SIVE animals; however, compared to both uninfected and SIVnoE animals, the number of CD68+Ki-67+ cells in SIVE animals was significantly higher, indicating an increase in Ki-67+ macrophages in SIVE.

Highly significant reductions in 12 phosphatidylcholines and significant changes in an additional 57 metabolites classified as amino acids, biogenic amines, acylcarnitines, glycerophospholipids and sphingolipids were observed in the PH compared to the control group.

The reconstruction shows a significant warming trend with a rate of 0.74 ± 0.12 °C/decade for the period 1970–2000, but a decreasing trend from 2001 to 2012.

F3 ′ H and F3'5 ′ H genes revealed contrasting patterns of expression in the four leaf stages, with an increasing trend for the former but a decreasing one for the latter, indicating a change in their relative importance in flavonoid biosynthesis during Hevea leaf development.

8b , the crack growth velocity shows a decreasing trend, which is understandable as the aggregated strain energy reduces with the crack growth.

Moreover, in the latter case speciation will also be impacted by the recrystallization rate, with a clear trend towards increased incorporation at faster recrystallization.

Although no data are available directly for our study site, data from nearby sites indicate a strong impact and declining reef health starting in the mid-1990s, with a decreasing trend in coral cover reported for MNP (west of Chichiriviche; from 55% in 1996 to 39% in 2011) and Los Roques National Park (north of Chichiriviche; from 44% in 1999 to 25% in 2012) 30 .

In the years following the mortality of 2010, regeneration seems to have occurred across all size-classes at 2 m, demonstrated by total coral abundance and proportion of larger size-classes generally following an increasing trend ( Fig. 1 ).

We also notice that the ME scores in terms of AJCC (pTNM) M stage show marginal significance ( Fig. 5B ), which may be affected by the small sample size of given metastases status.

We localized CAV1 in blood vessels of 2-day-old WT and DMD pigs, with an apparent trend of more stained cells in the latter group (see Fig. 2A ).

A positive β suggests an increasing trend and vice versa.