Excerpts

For leaf element ratios, we found that precipitation was the only factor retained in the C:P model and exhibited a marginally significant negative effect on this ratio (Table 1 ).

We also found that CHBs belonging to haplogroup D5 showed a trend towards having a very high VL and a lower frequency of VL <100 IU/mL (Fig. 3 ), which was considered as the cut-off for clinical HBV-DNA negativity.

The statistical significance of phenotype variables was assessed with the function anova.cca in vegan package, using 999 permutations to test for the marginal significance of each term after accounting for the effects of the others.

In many regions there was a clear trend for better agreement between rCPS estimates at higher injected doses.

Consistent with increased glycolysis with Age, citrate and isocitrate showed a trend towards increased abundance with Age in females (Fig.

The nitrate concentrations in the soil leachate were higher in May and mid-June than at the end of June and the end of July, and there was a decreasing trend of nitrate concentration over time.

In terms of clinical outcome, the 48 patients with EGFR mutation showed a trend towards longer DFS and a significantly longer OS, than those without EGFR mutation (Fig. 1A,B ; log-rank test, p = 0.069 and p = 0.015, respectively).

Second, an analysis of HR for bladder cancer stratified by obesity across smoking status strata showed a significant trend of increasing HR for bladder cancer across obesity and smoking status in multivariate-adjusted models.

The positive association between bladder cancer and BMI showed an increasing trend beyond the reference BMI.

This drug content is clearly significantly higher than conventional drug-loaded MSN having <1% wt. internal loading 16 , 35 , 42 – 45 .

This value was then correlated with the reported OGT, obtaining a positive trend.

Errors in the characterisation of these parameters would, therefore, cause possibly significant inaccuracies in model output.

The results of the function models showed a trend of initial increase and subsequent decrease in the vertical profile.

Under the NS treatment, as the soil depth increased, the coefficients of determination of the function models in the 20-, 40-, and 60-cm soil layers were consistent with those observed under the BL and exhibited an increasing trend.

Moreover, there seems to be an associative trend between NT-proBNP level and overall contour change of the arterial reflection wave, both of which can be due to RAS alteration, even in a short-term ARBs administration.

The results concerning the female hind legs can be summarized as follows: i) only the cortical bone of the tibiae was responsive to the SIT and showed alterations in the Cs.Th., ii) these alterations included a transient and not quite significant decrease after four weeks of SIT, iii) a very significant increase after eight weeks of SIT with iii) changes occurred at both, endosteal and periosteal surfaces with an emphasis on the distal half of the tibiae.

Beta-diversity analysis Average beta-diversity values were similar among years for the whole community (arithmetic mean ± SE: 0.419 ± 0.059 for 1997; 0.467 ± 0.070 for 2005; 0.444 ± 0.043 for 2012) and for the stygobiotic species (0.526 ± 0.065 for 1997; 0.632 ± 0.072 for 2005; 0.633 ± 0.049 for 2012; difference between 1997 and 2012 is in fact marginally significant), whereas increased significantly after the earthquake for the non-stygobites (0.340 ± 0.048 for 1997; 0.323 ± 0.044 for 2005; 0.535 ± 0.043 for 2012) (Table 3 ).

3D reconstructions show a decreasing trend in trabecular bone with no apparent changes in cortical bone (Fig. 2a ).

Although the mRNA expression of eNOS was unchanged, the protein expression of eNOS showed an increasing trend with increasing stretch magnitude (Fig. 3b , Table 1 ).

vgll3 showed a trend of being up-regulated, however this was not significant (P = 0.0519, Supplementary Fig.

Generally, cbhI gene abundance in early-rice season was generally higher than that in late-rice season, and the difference was extremely significant at d14 and d28.

The evaluation of the IgG titers against NadA showed an increasing trend with each vaccination dose in the groups that received NadA as part of the vaccine formulation (Fig. 5b ).

Moreover, the bacterial community diversity showed an increasing trend from endophytic to rhizoplane and rhizosphere soil.

These studies are highly significant and clinically relevant to understand the emergence of drug resistance; addition of Dasatinib to Docetaxel, a cytotoxic chemotherapy drug targeting microtubules, did not improve the overall survival in Phase 3 trials for chemotherapy-naive men with metastatic CRPC 33 .

An increasing trend in TDF values from 2.5 to 3.4‰ as crocodilians age was simulated in our analyses to examine the sensitivity of the trophic position estimate using varying TDF values 39 .