Barely Significant

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marginally non-significantP = 0.0551.1× alpha
When the ENTOSTAT-TiO 2 -encapsulated virus was considered alone, there was a marginally non-significant decline in performance over the 96 h exposure period (GLM: χ 2 1 = 3.69, P = 0.055), and when the 0 h simulated sunlight-exposure time point was excluded, there was no significant decline in performance (χ 2 1 = 0.31, P = 0.57), suggesting again that the virus is not subject to any further loss of efficacy after the first hour exposure to simulated sunlight.
marginally significantp = 0.0551.1× alphagold
We observed significant associations between both for midazolam (r = −0.48; p = 002), methylphenidate (r = −0.56; p < 0.001), haloperidol (r = −0.52; p < 0.001), olanzapine (r = −0.62; p < 0.001), low (r = −0.34; p = 0.028) and high (r = −0.57; p < 0.001) dose of risperidone, a marginally significant effect for escitalopram (r = −0.30; p = 0.055) and no significant effect for ketamine (r = 0.02; p = 0.913).
marginally significantP = 0.0551.1× alphagold
Paired sample t tests revealed a marginally significant decrease in AD in the multi-domain CogTr group (student’s t (16) = 2.066, two-tailed P = 0.055); conversely, no significant alteration was seen in the controls (student’s t (13) = −0.401, two-tailed P = 0.695).
a strong trendp = 0.0551.1× alphagold
The pathways analysis outcome between 10 weeks and 6 weeks old 5xFAD mice showed a clear upregulation of immune system related pathways such as interferon-gamma signalling pathways and a strong trend for altered B and T cell activation pathways and interleukin pathways in the 10 weeks old 5xFAD mice (p = 0.055, p = 0.071, respectively) which goes along with the alteration of cytokines we detected in 10-week old 5xFAD brains.