It might be significant to consider the successes while keeping this context in mind.
Excerpts
Nuclear-transcribed mRNA catabolic processes, nonsense-mediated decay, SRP-dependent co-translational protein targeting to membrane, and translational termination, all of which are closely related to lung cancer, were reported as highly significant GO terms (top 10 p -values) corresponding to the selected characteristic genes.
Through sensitivity analysis, there was, however, a highly significant interaction between age (as a continuous variable) and year, with the strongest declines in HSV-1 seroprevalence in the younger age groups for both men and women—the declines decreased in strength (odds) by 0.0013, i.e. 0.13% (95% CI: 0.05–0.21%) per year of age among men, and by 0.18% (95% CI: 0.10–0.25%) per year of age among women.
Among our observed novel interactions, some may be significant, and fall into a few categories ( Table 6 ).
Some of these findings are likely to be significant at therapeutic doses, such as σ1R binding that is only 2.3 fold over MOR affinity for hydrocodone and approximately equal affinity to MOR for tapentadol.
by sex (p = 0.06), age (p = 0.34), or location (p = 0.06), although sex and location approached significance.
Such an increasing trend was also observed in South America (the HPE prevalence after 1996 was nearly twice of the prevalence before 1996).
Nevertheless, although Eastern Europe (Hungary, Lithuania) has become one of the leading geographical regions based on suicide mortality rates, there is now evidence of an increasing trend in Asia (particularly South Korea) [ 30 ].
Results There has been a decreasing trend in the number of femicides per year.
Low average agreement with the gender-normative statements in Table 3 was selected as a protective factor against rape (p = 0·06), although not quite significant at the 0·05 level.
a weak trendgold
There was a weak trend of men having a shorter intersurgical interval, but after controlling for the far stronger, and statistically significant, variables of country and time since diagnosis with multiple linear regression, there was no association with gender.
Associations with KIR2DS4 were marginally non-significant after correcting for multiple comparisons.
Partitioning of the observed phenotypic variations into different sources of variation via the mixed model analysis revealed a highly significant effect of accession for the three traits considered ( Table 1 ).
a strong trendgold
We also observe that more than doubling the daily antioxidant-rich food intake [ 30 ] attenuated the altitude-induced increase in micro-CRP, IL13 and a strong trend for IL6.
(2012) that showed a trend towards higher resistance levels in some household areas where biocides are used [ 29 ].
The expression of the gustatory receptor gene showed a trend in which the expression level of TchiGR43a declined from the larval stage to the prepupal stage, then increased from the prepupal stage to the pupal stage and declined again at the late stage of the pupa ( Fig 4A ).
On r15, both groups showed a decreasing trend in orthodontic relapse as compared with r0.
M100 and M200 significantly reduced GI and reached a highly significant level ( Fig 3A ).
In the wild-type Col-0, the free amino acid concentration shows an increasing trend during the light period, while levels drop during the dark period, in line with earlier studies ( Fig 2A ) [ 20 ].
This trial failed to reach statistical significance, however, a clear trend towards improved response rates and prolonged median progression-free survival (mPFS) of combined SSA treatment + VEGF inhibition compared to monotherapy SSA was observed.
rC2 and/or d2DS1 negatives gave a lower and barely significant p value of 0.046 (not shown).
By contrast, irrigation had a strong, highly significant, and direct effect on Y 1 , Y 5 , and Z in at least two experimental years ( Table 5 ).
Results Lower maternal age was predictive of SSSI, with current smoking status and longer wound open times being marginally significant.
The two CK N- glucosides (tZ7G and tZ9G) showed highly significant positive correlations between each other, and both were positively correlated with tZOG.
While the Hispanic/Latino index SNP in CDKN1A (rs3176326) was not directly evaluated in the European or African American GWAS, it was in high LD with a SNP that had been found to be highly significant in the previous European ancestry GWAS (r 2 = 0.71 with rs9462210).