Barely Significant

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a trend level of significancep = 0.051.0× alphagold
However, patients with PD showed increased RD values compared to HC subjects with a trend level of significance ( p = 0.05 TFCE-corrected), located in clusters including the anterior corona radiata (frontal lobe WM), genu of the corpus callosum, and body of the corpus callosum in the left hemisphere, and the frontal WM in the right hemisphere.
a strong trendP = 0.051.0× alphagold
Expression increases in miR-186 from post- to 60 min post-exercise (fold change = 1.58, P <0.001) paralleled a significant upregulation of SIRT6 mRNA (fold change = 1.66, P <0.05), a significant downregulation of TERF2IP mRNA (fold change = 0.54, P <0.01) and a strong trend towards significance for RAD50 (fold change = 0.76, P = 0.05).
highly significantp<0.051.0× alphaqualifiedgold
Manual forward selection, starting with variables that were more strongly associated with prevalence in univariable analyses, was applied and variables were retained in the multivariable model if p<0.2.The variables that were highly significant (p<0.05) in multivariable meta-regression model were considered as building blocks for interaction terms.
borderline significantp = 0.05001.0× alphagold
1 , Panel B) [median: 2.220 (IQR: 0.908–3.647) vs 0.461 (IQR: 0.353–1.048); p = 0.0373], while between CC and CT groups a borderline significant difference was observed both at basal level ( Fig. 1 , Panel A) [median: 1.420 (IQR: 0.875–1.655) vs 0.676 (IQR: 0.468–1.137); p = 0.0500] and after exposure to IFN-alpha ( Fig. 1 , Panel B) [median values: 2.220 (IQR: 0.908–3.647) vs 0.840 (IQR: 0.397–1.599); p = 0.0500].
borderline significantp = 0.051.0× alphagold
Intermittent opioid use appeared to be associated with decreased memory CD8+ T cells proportion (CD45RO+CD45RA- CD8+ T cells: adjusted mean difference [AMD] [95% CI] = -6.15 [-11.50, -0.79], p = 0.02) and borderline significant increased senescent T cells (%CD57+ of total CD28-CD8+ T cells (AMD [95% CI] = 7.70 [-0.06, 15.46], p = 0.05).
highly significantp ≤ 0.051.0× alphaqualifiedgold
The expression profile of NFE2L2 target genes ( Fig 4A ) demonstrates a majority of such genes to have highly significant differences in mean expression between MR and Control samples (adjusted p ≤ 0.05 for 18/21 genes) with moderate to large effect sizes (absolute fold-changes 2-fold or higher).