Barely Significant

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After sex stratification, a decreasing trend in insulin and HOMA-IR versus baseline was found only in women, although it did not achieved statistical significance (change in women vs. men, insulin: women −2.2 ± 1.2 vs. men 4.1 ± 2.7; p = 0.054; HOMA-IR: women −0.41 ± 0.32 vs. men 1.05 ± 0.67; p = 0.072).
The sex-by-SES trajectory interaction terms did not show any significant association, and only the interaction between men and a stably low SES trajectory showed a marginal trend of association with Δage ( p for interaction = 0.1; Table S3 ), which was confirmed in sex-stratified analyses (β (CI) = 0.35 (−0.39 to 1.08) in men vs. 1.02 (0.34 to 1.70) in women; ( Table S4 )).
Although the results were marginally significant, there exists a potential association with LMM, suggesting that the nutritional imbalance resulting from a diet characterized by a reduced intake of protein-based foods, alongside increased consumption of refined carbohydrates, high glycemic index foods, and saturated fats, may contribute to the decline in muscle health.
After a 12-week intervention, compared with the placebo group, the probiotic group showed a significant increase in muscle mass and fat free mass ( p < 0.05), a significant decrease in fat mass ( p < 0.05) and a decreasing trend in body weight; however, the difference was not statistically significant ( p = 0.07).