Barely Significant

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Although demented individuals showed a trend toward lower microbial diversity, our results suggest that dementia-related alterations are characterized less by a global loss of diversity and more by specific compositional shifts, with depletion of beneficial taxa and enrichment of potentially harmful ones, resulting in a distinct microbial signature.
Western blot analysis showed that although the phosphorylation of AMPK (p-AMPK) exhibited an increasing trend in the MG5012- and MG741-treated groups compared to the HFD group, this difference did not reach statistical significance ( Figure 4 F,I).
highly significantqualifiedgold
For metabolic variables examining fat oxidation across 30 studies, sequential exclusion revealed no influential outliers, with pooled fat oxidation increase remaining highly significant (Cohen’s d = 1.72, 95% CI: 1.42–2.02) after excluding the study with the largest effect (Volek et al., which showed a 2.3-fold increase [ 7 ]), indicating robust findings across independent investigations.