Excerpts

Interestingly, the mutational status of these three genes showed marginally significant mutual exclusivity (CoMEt algorithm, Fig. 4d ), and analyses on additional patient cohorts are required to confirm this pattern.

Importantly, a comparative analysis of the genes downregulated upon CtBP1 depletion showed a highly significant overlap with the genes downregulated upon FBXO32 depletion (Fig. 4b ).

9b ) and the plot demonstrates an increasing trend from low I r in small tubes to high values in large ones, where the I r plateaus.

Applying the same analysis to stage II breast cancer patients revealed that the CINP metagene was associated with a marginally significant difference in 5-year survival by TCGA analysis but not by METABRIC analysis (Supplementary Fig. 4b, c ).

Major hurricane frequency is consistently related to relative SST 5 (difference between MDR SST and tropical mean SST), as they are correlated while neither index has an obvious trend (Fig. 2b ).

We found that the CDR3B length distribution for proinsulin-specific 39 and autoreactive clones 31 – 38 shows a clear trend to being shorter than expected (Fig. 8e, f ).

This established highly significant reduction in the primary tumor size and metastatic spread during dual-delivery treatment or administration of OX/LB-MSNP (Supplementary Fig. 10a, b ).

After accounting for this phylogenetic structure, parity mode remained a highly significant predictor of social grouping across species (Table 1 ).

We found an almost significant deficit of genes responding to sexual selection on the older part of the X chromosome (XL) and that XR contains a deficit of sex-biased genes.

Strikingly, we note a highly significant trend between predicted impact by EA and actual phenotypic perturbation (Fig. 4c ), as previously shown in a retrospective analysis 31 .

By evaluating the concentrations of each agent (on a molar basis of MMAE) that inhibited cellular viability by 50% after 72 h (i.e., the IC 50 values), a clear trend emerged: the relative potency of free MMAE > NP(MMAE) > CNP(MMAE) for each cell line (Supplementary Table 3 ).

Because statistical errors in the MSD may be significant for short trajectories, only tracks with N ≥ 5 were included in the analysis.

Moreover, across the five microarray FSHD studies, although no individual study showed statistically significant elevation of DUX4 target gene expression, all studies showed a positive trend towards this.

These younger repeats still possess mobilisation ability 39 and are more likely to be significant contributors to the population variation and haplotypic differences through direct and regional positional effects.

A clear trend can be seen and reflects that the Debye–Waller factors of the different atoms do not scale proportionally with temperature.

The calculated blood flow volume in the uterine artery (cQuta) corrected for maternal body weight demonstrated some variability between ZIKV animals, but revealed an overall trend to increasing with advancing gestational age, as would be anticipated (Fig. 5c ).

Indeed, only one of the top 5 loci from the overall marginal GWAS showed nominally significant interaction effect, and none passed Bonferroni corrections.

This is a fairly significant increase on top of the IPCC scenario given that total increase in global temperature since the industrial revolution is about 1 °C 27 that can significantly increase the required speed and extent of future emission reductions.

and displays an increasing trend into the current era.

Maturation markers Pdx1 , Nkx6.1 , and Neurod1 were significantly upregulated in adult islets, and Mafa and Ucn3 showed a trend towards increased expression (Fig. 1j ).

Finally, Δ-TT>A mice showed a trend toward higher CXCL10 and KC chemokines in serum, and ANA positivity (Supplementary Fig. 13b, c ).

Analysis of the transcriptomic datasets Pre-normalized public circadian transcriptomic microarray (GEO accession: GSE54650 7 ) and aging transcriptomic data sets (GEO accession: GSE57809 26 and GSE6591 27 for the liver and lung, respectively) were used for detection of circadian (see “Detection and analysis of circadian epigenetic oscillations”) and nominally significant aging mRNAs (see “Aging analysis for the mouse tissue DNA samples”).

Over evolutionary time, terrestrial mammalian lineages show a significant trend toward larger body size—Cope’s rule 29 – 32 .

The J sc values show an increasing trend from approximately 15 to 19 mA cm −2 with the increase of the active layer thickness.

However, neither the Resilience nor the Food Waste metrics show such a strong trend (Table 1 ).