Excerpts

Of note, the assistance of other proteins, in burying the long alkyl moieties when expelled from FasR and other lipid-sensing TFRs should not be ruled out, as they might be significant components of the thermodynamic equations.

NDVI max has been found to have a highly significant correlation with NPP in a large range of different dryland ecosystem 31 – 33 .

We also assessed whether variants within 23 genetic loci that been previously identified in other studies with marginal significance as associated with classic KS, KSHV seropositivity, KSHV viral load, antibody response or primary effusion lymphoma 21 , 23 – 25 , 34 – 36 were present in this study and had plausible signals.

Principal component analysis (PCA) showed a trend to separate both the metaproteome and the lysine acetylome for CD versus control (Fig. 4a , b).

In this context, any marker that unites ciliary bands in one clade might be significant.

At the genus level, we identified 20 highly supported inter-genus host switches for α-CoVs, 17 of them were also highly significant using the random subset (Fig. 5a and Supplementary Table 6 ).

9g–l shows that group differences in memory-dependent biases remained marked (a reduction of 2.51° for schz, and 1.62° for enc in the 3 s delay condition) and highly significant even after conservatively controlling for CPZ.

Metabolite identification using structural ontologies showed a trend towards regulation of sulfur metabolism pathways (Supplementary Fig. 5a , Supplementary Data 1 ), however enrichment analysis did not reach statistical significance.

We also identified several cancer pairs for which the genetic correlations were nominally significant.

7 ), whereas the HSP90 co-chaperone Smyd1 (also important for myosin assembly) 35 showed a strong trend toward reduction in MUT (Fig. 7c ).

In line with this and the results in the TZH cohort, the 60 hypomethylated gsSMK-CpGs exhibited a clear trend toward hypomethylation in smokers in the Liu, Hannum, and Tsaprouni cohorts, which was only consistent and much stronger in myeloid cells (Fig. 2b–d ).

These analyses confirmed that the 53 gsSMK-CpGs exhibited highly significant trends toward hypomethylation in smokers in both lineages, but more strongly so in myeloid cells (Fig. 1e, f ).

As the p value of BMP7 is close to significance in the multivariate model, we searched in The Gene Expression Omnibus (GEO) database for a second cohort of lung adenocarcinoma patients to have at least 100 patients.

The overlap between the respective differentially expressed genes was highly significant in almost all comparisons (Fig. 5c , Supplementary Fig. 3d , and Supplementary Table 6 ) and the observed expression fold changes were consistent with the notion that IL-6/HIL6 stimulation recruits progenitor populations from both more differentiated and more stem-like populations, with the dedifferentiation branch (MatLum → LumProg) being more consistent than differentiation (MaSC → LumProg).

does not show a significant trend, which is in line with the work of 34, 20 where no increase in IVT or precipitation trends have been found over a large period of time (Supplementary Fig. 6b, c ).

However, such recovery was missing in 2020 due to the lockdown, leading to a decreasing trend all through the first quarter.

In this condition, we did not find a significant trend over rounds when private solutions were available, indicating that unequal access to private solutions also diminishes the ability of groups to coordinate on a more efficient communal solution over time (see Supplementary Note 6 for details).

The political costs of such curtailments may be significant, but so will be the costs of inaction.

The DMP distribution showed a trend toward hypomethylation for CG and CHG, with the exception of Col-0/ msh1 sample 3 that showed slight CHG hypermethylation, whereas CHH DMPs showed hypermethylation in all cases (Supplementary Fig. 7a ).

RNA recovery within the whole droplet showed an increasing trend as the water was lost from the coacervate mixture (Fig. 3e ).

Within the ATX group, we observed a positive trend between the pupil dilation response and the neural spread of association in parahippocampus-hippocampus (Fig. 6f ).

In addition, we identified a nominally significant enrichment for microglia/astrocyte OCRs in Alzheimer’s disease, which is consistent with a recent study implicating microglia enhancers in Alzheimer’s disease 38 The cell-specific map of chromatin accessibility generated in this study can be used to deconvolute bulk tissue ATAC-seq data from the human brain cortex.

Lower healthy tissue uptake (toxicity) with loading dose When the total antibody dose increased from 0.3 mg kg −1 to 2.6 mg kg −1 , muscle uptake of the antibody–dye conjugate (%ID kg −1 ) showed a decreasing trend (Fig. 2a ), suggesting that co-administration of unlabeled antibody saturates the estimated glomerular filtration rate (EGFR)-binding sites in the muscle and thus reduces the target-mediated uptake (relevant for ADC toxicity) in healthy tissue.

In our study, we found a highly significant increase in both infection rate and number of symptoms when people attended carnival festivities, as compared to people who did not celebrate carnival.

Species showing a significant or marginally significant shift according to K-S test were the same that showed a significant difference between deciles.