Barely Significant

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Several measurements showed a highly significant age effect and a significant, although low, visit effect, including total cholesterol (β age = 0.026, 95% CI: [0.021 – 0.032]; t -test P adj = 7.7 × 10 -19 ; Fig. 2f ) and diastolic blood pressure (β age = 0.022, 95% CI: [0.016 – 0.027]; t -test P adj = 1.5 × 10 -12 ).
We also detected a decreasing trend in monocyte-like macrophages (Mac_Mono), C1Q-related macrophages (Mac_C1Q), resident tissue macrophages (Mac_RT), and IFN macrophages (Mac_IFN) in TLS regions compared with non-TLS regions, but no significant differences in the distributions of plasma cells or other macrophage/DC subsets were found (Supplementary Fig. 10b, c ).