Excerpts

Entering strength of reprocessing in SWS and time spent in this sleep stage in a regression model, we found that only strength of reprocessing in SWS was a significant predictor of memory consolidation and explained a larger part of the variance ( β =0.335, P =0.006, explaining 11.2% of the variance), whereas duration of SWS was only marginally significant ( β =0.214, P =0.074, explaining 5.2% of the variance).

acidifaciens exhibited an increasing trend ( P = 0.0749) (Fig. 3D ).

Linear regression analysis revealed SERPINA5 expression associated with the advanced marker of tangle maturity ( p = 0.010) and approached significance with microgliosis ( p = 0.075) (Figs. 4h , 5c , and Supplementary Fig. 11 ).

In univariate Cox regression analysis, no clinical parameters were associated with OS except for ECOG status at enrollment that was near statistical significance ( p = 0.075) as well as receiving four or five previous treatments ( p = 0.065 and p = 0.083 , respectively; Supplementary Table 8 ).

The difference between the hot and cold regime tended to be greater at 35 °C, although the two-way interaction between regime and assay temperature was marginally non-significant (F 2, 11.9 = 3.25, P = 0.075, Fig. 5A ).

An increase in aldosterone levels during the eighth hour and in prolactin levels during the third hour after stimulation onset approached significance ( p ≤ 0.075; Fig. 2c, d and Supplementary Fig. 3b, c ), with exploratory analyses revealing enhanced prolactin levels after stimulation at two of the 15-min samplings (150 min and 165 min post-stimulation onset, respectively, p ≤ 0.050).

For noise trials, the time period from −300 to −50 ms before the critical phoneme still showed a trend for above-chance classification accuracy (one-way t test t (5)=2.25, P <0.075, uncorrected), although it was less than when separate classifiers were trained over time ( Supplementary Fig. 10 ).

The ERS analysis between amygdala and hippocampus was close to significance (summed t-value = 18.38, P = 0.075, n = 12; Supplementary Fig. 13b ), potentially suggesting that the information carried by more than one peak may be needed for the reactivation process.

Last, by using chromatin immunoprecipitation PCR in CLU177 cells with knockdown of HDAC5, we observed a strong trend towards reduced binding of STAT3 to its cis -regulatory element near the transcriptional start site of the Pomc promoter ( P =0.075, two-tailed t -test; Fig. 4l ).

Comparison of the histological grade of synovitis 30 between hand and knee RA showed a trend towards a higher synovitis score in RA hands (mean: 5.25 ± 1.78) compared to RA knees (mean: 4.31 ± 1.78; difference −0.94 ± 0.52, p = 0.076), as previously seen 17 (Fig. 1a ).

Furthermore, we also found a strong trend to increased protein nitrotyrosination (a hallmark of oxidative stress) in Gata5 -null mice mesenteric arteries ( P =0.076, t -test) ( Fig. 3j ), reflecting a possible imbalance in oxidative stress that may contribute to decreased NO bioavailability 22 .

Participants’ responses showed a trend of being slower when switching entailed greater costs ( t 28 = 1.844, p = 0.076, CI 95 = [−0.003 to 0.056], U3 1 = 0.345).

The pseudogenes on the neo-X showed a higher ratio of genes with female-benefit/male-detriment effects to genes with male-benefit/female-detriment effects than functional genes (16/13 [1.23] versus 29/51 [0.57], respectively), although the difference was only marginally significant ( χ 2 test: χ 2 =3.1, d.f.=1, P =0.076, Table 1 ).

The importance of semi-quantitative information on pneumococcal density in these analyses was further supported by a borderline significant association between baseline microbiota composition and density of pneumococcal colonization at day 2 ( R 2 = 1.7%, p = 0.076; Supplementary Table 3B ).

Post hoc t -tests (Bonferroni corrected) revealed that high PE subsequent accuracy (mean = 55.4 ± 6.6%) was significantly greater than that of the other levels (0 mean = 20.7 ± 2.1%, t (19) = 5.7, and p < 0.001; low mean = 24.4 ± 2.1%, t (19) = 4.9, and p < 0.001; and medium mean = 30.4 ± 3.5%, t (19) = 3.9, and p < 0.01), as well as a difference between medium and 0 PE accuracy of borderline significance ( t (19) = 2.8, p = 0.076).

A Welch’s two-sample t test of PC1 scores revealed that AHR activation showed a trend toward significance ( t = 2.68, p = 0.076), whereas no meaningful effects were observed for other pathways: AR (t = 0.48, p = 0.68), ER ( t = − 0.93, p = 0.43), and SP1 ( t = 0.37, p = 0.74) (Supplementary Fig. 4c ).

In contrast, we observed a strong trend for a decreased mixture response in solitarious animals ( p = 0.0761).

Furthermore, four genes showed a borderline significant association: vitronectin ( VTN , adjusted P = 7.64 × 10 -2 ), the complement regulatory protein CD46 (adjusted P = 7.24 × 10 -2 ), coagulation factor II receptor-like 2 ( F2RL2 , adjusted P = 7.24 × 10 -2 ), and alpha-2-macroglobulin ( A2M , adjusted P = 7.64 × 10 -2 ) (Table 1 ).

The HER2-positive cohort was subdivided into low- and high-NRG1 groups based on their initial label, and subjected to Kaplan–Meier survival analysis, which revealed that NRG1 expression significantly impacted DFI, with PFI reaching near statistical significance ( P = 0.0767), where the high-NRG1 group exhibited worse prognosis (Fig. 6f, g ).

Our findings suggest that both types of novelty were represented in the memorability subspace following event boundaries, with strong evidence for co-occurrence novelty (R2 difference = 0.23, p = 0.009, from a one-sided permutation test) and a marginal trend for valence novelty (R2 difference = 0.10, p = 0.077), but not preceding them (co-occurrence novelty: R 2 difference = 0.03, p = 0.212; valence novelty: R 2 difference = −0.04, p = 0.892) (Fig. 5C , Supplementary Fig. 7A , B ).

For the PANSS measures, interactions between medication group and occasion were significant for positive (F 4,133.6 =4.48, P =0.002), general (F 4,125.3 =4.52, P =0.002) and total scores (F 4,125.0 =4.59, P =0.002), and were trending towards significance for the negative scores (F 4,129.4 =2.16, P =0.077).

However, for 17q11.2, its loss/deletion status was related to worse DMFS with borderline significance (hazard ratio = 1.8, P = 0.077) (Fig. 5f ).

In the SMC cohort, we observed a trend towards significance ( P = 0.077; Odds Ratio, 1.45; 95% CI, 0.94−2.21) compared to KOREA1K, while in the TARGET cohort, we found a statistically significant difference ( P = 0.027; Odds Ratio, 1.46; 95% CI, 1.04−2.05) compared to the TCGA cohort.

The enrichment of putatively functional germline variants in cancer predisposition genes is borderline significant when compared to healthy populations ( P = 0.077; Odds Ratio, 1.45; 95% confidence intervals, 0.94−2.21) and significantly more pronounced against adult-onset cancers ( P = 0.016; Odds Ratio, 2.13; 95% confidence intervals, 1.10−3.91).

CD4 was not statistically associated with therapy response, while a trend towards significance was detected with CD8 (Mann–Whitney's P =0.077; Supplementary Fig. 7 ), as has been previously described 18 .