Excerpts

Channels demonstrating a positive trend were identified with P < 0.05 and a Mann–Whitney Z -value that was positive, whereas channels with a negative trend were identified with P < 0.05 and a Mann–Whitney Z -value that was negative.

Six of the 27 unconditional (22.2%), and 3 of the 13 conditional (23.1%) SNPs had nominally significant ( P <0.05) heterogeneity, much more than the 5% expected by chance ( Supplementary Dataset 1 , Supplementary Tables 1–3 ).

In total, 63 loci have shown at least marginal significance ( P <0.05) with ER-negative breast cancer.

The dust-induced RF in SSP126 shows a slightly increasing trend ( p < 0.05 from the MK test) that switches to a slightly decreasing trend ( p < 0.05 from the MK test) if future dust deposition remains at the historical value (Fig.

All signals show at least nominally significant ( P <0.05) directionally concordant associations in the follow-up studies of clinically validated PCOS cases, with no significant heterogeneity by PCOS case definition ( Supplementary Table 2 ).

Out of 34 comparisons, 26 were nominally significant ( p < 0.05), and 22 passed the Bonferroni significance threshold (0.05/34 = 0.00147).

Probability values <0.10 but >0.05 (0.10< P <0.05) were considered marginally significant, and values <0.05 ( P <0.05) were considered significant.

ClinVar data were downloaded as VCF (accessed 02.05.2022) and filtered for nominally significant single variants ( P < 0.05 in any phenotype model).

We performed immunoprecipitation-mass spectrometry (IP-MS) identification of N-terminal-tagged CLK2-associated proteins (4 FLAG-tagged replicates, one untagged CLK2), using tandem mass tags (TMT) mass spectrometry and observed highly significant enrichment (Fig. 6a , Supplementary Data 32 ) of both known CLK-interacting proteins (28/97 known, B-H adjusted Wald p < 0.05) including CLK1 and additional splicing factors (98/270 total enriched, B-H adjusted Wald p < 0.05).

Among 15 associations with more than two instrumental variables (9 metabolites, 7 FinnGen outcomes), seven associations (3 metabolites, 6 outcomes) remained nominally significant ( P -value < 0.05) in MRPRESSO outlier test.

Univariate linkage disequilibrium score regression (LDSC) 24 analysis showed nominally significant heritability for all 37 phenotypes ( P < 0.05, Table 1 ).

3c ), and immune scores showed a trend and modest correlation with PFS (Spearman ρ = 0.35, p = 0.05; Fig. 3d ).

We found 99.3% (5442/5478) of the FDR significant associations also had a nominally significant ( p ≤ 0.05) association in the Spearman rank test (Fig.

While integrative analysis of pathways restored by the microbiota-targeted interventions did not yield any FDR-significant results in either sex, several nominally significant pathways ( p- value < 0.05) were observed, highlighting potential effects on developmental, signaling, and metabolic processes.

We then determined the time series of β SOT using 15-year moving windows from 1982 to 2021 at each pixel and found that 38.6% of regions exhibited a significant increase in β SOT for kNDVI, while 22.0% showed a decreasing trend ( p < 0.05) (Fig. 1A ).

A total of 68 salt-related metabolites showed nominally significant associations with various salt-related gut-microbial species and functional pathways ( p < 0.05), indicating that the changes in gut microbiota may contribute to the changes in metabolite (Supplementary Figs. 8 and 9 ).

The Mann-Kendall method was then used to test the significance of the trend, which indicates a significant trend change when p < 0.05.

After filtering to the 176 clock-disease associations that were Bonferroni significant in the Cox models, there were 32 instances where the AUC improvement between the null and full model was greater than 0.01 and nominally significant at P < 0.05 (Fig. 2 and Supplementary Data 8 ).

Depending on the model type selected, between 8% and 19% of protein pairs exhibited a nominally significant correlation ( P < 0.05) between predicted and observed expression/co-expression in all three models, but this percentage rose to over 99% in well-imputed pairs.

In the AFR samples, we found no significant effects in any of the examined p -value thresholds, although all but one were nominally significant ( p < 0.05).

2 F), we observe a weak trend with the log volume of data per subject (Fig. 2 G, p < 0.05).

Of the 174 lead SNPs identified in the discovery cohort, 145 (83.3%) remained nominally significant ( P < 0.05) in this replication dataset.

Markers with nominally significant p-values in one or more cell populations ( P ≤ 0.05; e.g CD39, CD38, Ki-67, PD-1) were visualized in boxplots; statistical significance computed using the linear mixed model were further confirmed using non-parametric Wilcoxon rank sum test.

However, in successive models of Model 3 and 4 (addition of POAG established and suspected risk factors), and Model 5 (further adjust for co-morbidities), we observed that while no metabolite exhibited significance at the NEF < 0.2 level (except for LPC(16:0) in Model 3), all were nominally significant and the direction of associations for the metabolites was similar ( p < 0.05).

To filter out low signal phenotypes that may generate outliers, results 500% away from the mean or where not all three models (linear, nonlinear or baseline) were at least nominally significant ( p < 0.05) were removed.