Excerpts

To filter out low signal phenotypes that may generate outliers, results 500% away from the mean or where not all three models (linear, nonlinear or baseline) were at least nominally significant ( p < 0.05) were removed.

P- values of less than 0.05 were considered statistically significant, and a statistical trend was recognised for p- values of 0.1 ≥ P ≥ 0.05.

3e ), which is marginally significant ( p = 0.05).

While only variants with P < 5 × 10 −8 were considered significant, to also identify suggestive variants for supplementary results, in each clump, index SNPs had a suggestive association based on P < 1×10 −6 , and SNPs were added if they were marginally significant with P < 0.05, were within 500 kb of the index SNP, and had r 2 > 0.1 with the index SNP.

All of the 28 SNPs showed a nominally significant association ( P < 0.05) with ER-positive breast cancer risk (Table 2 ).

Of these 86 variants, 67 replicate at the nominally significant threshold ( p < 0.05) in the current GWAS of MVP-CBP, and 54 replicate at the Bonferroni-corrected threshold (Supplementary Data 12 .

Eight of the 13 ALFRED genes with a nominally significant association between RDGVs and AI in at least one cancer type in the ALFRED analysis ( P < 0.05; Fig. 2d and Supplementary Data 5 ) also had an enrichment of RDGVs in a matched cancer type compared to in controls ( P < 0.05, Fig. 3d ; Supplementary Data 6 ): ATM in colon and rectum adenocarcinoma (COADREAD), lung adenocarcinoma (LUAD) and in PRAD, NSD1 in OV, and TPCN2 in uterine corpus endometrial carcinoma (UCEC).

Of note, 8 metabolites such as indole-3-carboxyaldehyde, tyrosine, citrulline, 3-hydroxypyridine, or 4-hydroxybenzaldehyde positively correlated with tibia SOS, although only nominally significant ( P < 0.05, Q < = 1).

31 by including as IVs only the eGFR-associated genetic variants ( p < 5 × 10 −8 ) with additionally having directionally consistent and nominally significant p-value (p < 0.05) with i) eGFRcys or ii) BUN.

According to BADGERS, the reference panel comprises 1738 traits from the UKB 17 , selected on the basis of nominally significant SNP-based heritability ( P < 0.05).

6 , which showed marginal significance for all three variables ( P = 0.05, 0.06, 0.05, respectively).

AEI values were significantly elevated in T21 compared to controls in the PFC ( p = 0.01, linear regression), and showed a marginal trend in the hippocampus ( p = 0.05) (Fig. 5B ).

The correlations between insulin, LPS, and ssDNA direct ELISA assays to insect cell PSR staining were highly significant ( p < 0.05), while bare plastic and dsDNA direct ELISA assays were modestly significant ( p < 0.10).

Differences between each group were determined to be significant using one-way ANOVA (* p < 0.05, significant; ** p < 0.01, *** p < 0.001, highly significant, the Multiple Comparisons by Tukey) or analyzed by unpaired two-tailed t -test (* p < 0.05, significant; ** p < 0.01, *** p < 0.001, highly significant).

While none passed multiple testing correction, mainly because of a lack of power since we have a limited sample size in an analysis with thousands of parameters (clones), we could observe that the few clones that approached significance ( P -value < 0.05) were shared across patients only in PR group and enriched at 24 months post transplant.

First, to validate the reproducibility of highly significant gRNA–gene associations (Bonferroni P ≤ 0.05 in each screen), we performed the same inference on the small-scale screen.

We evaluated how well independent pQTLs reported by the INTERVAL study 9 ( n = 3301) replicated in our results and found 75.6% to be both directionally consistent and nominally significant ( P < 0.05) (Supplementary Note 2 and Supplementary Figs. 6 and 7 ).

After filtering to the 176 clock-disease associations that were Bonferroni significant in the Cox models, there were 32 instances where the AUC improvement between the null and full model was greater than 0.01 and nominally significant at P < 0.05 (Fig. 2 and Supplementary Data 8 ).

Among female-specific fertility traits, LDSC identified nominally significant ( P < 0.05) r g between increased MPB severity and fewer number of live births ( r g = −0.06, SE = 0.02) and increased age of first birth ( r g = 0.04, SE = 0.02) (Table 1 ), suggesting shared genetic risk.

For the ΔHR ex trait, published resting HR SNPs at four loci were genome-wide significant ( SOX5 , RNF220 , SYT10 and PPIL1 ), while 25 additional loci were nominally significant (5 × 10 −8 < P < 0.05; Supplementary Data 2 ).

Lastly, we classified the sex-mQTLs with FDR-adjusted P diff < 0.05 into one of the following three categories: (i) concordant effect: association found to be FDR-significant in one sex and nominally significant ( P < 0.05) or FDR-significant in the other sex with a consistent effect direction but different magnitude; FDR-adjusted P diff < 0.05.

Interestingly, we found that tumors with 9p21.3 deletion had lower level of CD8 + tumor infiltration lymphocytes (TILs) than those without 9p21.3 deletion, with marginal significance (Student’s t -test, P = 0.05; Supplementary Fig. 10a ).

Genes with nominally significant ( P < 0.05) estimates of SNP-heritability (cis- \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$h_g^2$$\end{document} h g 2 ), are then put forward for training predictive models.

Secondary GWAS ( N = 255,426), excluding shiftworkers and individuals with chronic health or psychiatric illnesses, additionally identified significant variants in SEMA3D and revealed marginally significant interactions with health status at PATJ, ZENF326/BARHL2, ECE2, ASAP1 , and CYP1A1/CYP1A2 (interaction P < 0.05; Supplementary Fig. 6 , Supplementary Table 7 ).

In contrast, individual deletion of either Sulf1 or Sulf2 resulted in a highly significant increase in CC1 + Olig2 + oligodendrocyte density relative to wt (two-way ANOVA, main effects p < 0.05).