Excerpts

Within the Roopkund_A group which has ancestry that falls within the variation of present-day South Asians, we observe a weakly significant difference in the proportion of West Eurasian-related ancestry in males and females ( p = 0.015 by a permutation test across individuals; Supplementary Note 8 ), with systematically lower proportions of West Eurasian-related ancestry in males than females.

By contrast, dmPFC encoded model-based confidence estimates on both trial types: activity decreased with confidence on other-trials, but increased with confidence on self-trials, although the effect on self-trials did not reach statistical significance (c-HRF regression; confidence on other-trials, t (20) = −2.67, p = 0.015; confidence on self-trials, t (20) = 1.79, p = 0.089).

For example, ARID1A , which is part of the ATP-dependent chromatin remodeling complex SNF/SWI, was associated with sensitivity to topotecan, a DNA topoisomerase I inhibitor, in STAD ( P BH = 1.68 × 10 −3 ) and nominally significant in UCEC (raw P = 0.016).

The considered measures of epigenetic AgeAccel exhibit nominally significant positive correlations with motor progression (e.g., r = 0.08, meta-analysis p = 0.016 for the pan-tissue clock; Supplementary Table 8 and Supplementary Fig. 7 ).

There is only a weak, marginally significant negative correlation between the level of resistance and fitness cost (Supplementary Fig. 1 , Spearman’s rho = −0.24, P = 0.016 ( N = 98)), and this correlation becomes non-significant after controlling for drug type ( P = 0.6 and P = 0.39 for antibiotics ( N = 60) and AMPs ( N = 38) respectively, Spearman’s correlation).

After controlling for the mean pure-tone threshold at speech-relevant frequencies, activity in the left POp and preCG/postCG showed a trend of correlation with accuracy in older adults (partial r =0.604 and 0.612, uncorrected P =0.017 and 0.015, respectively, FDR-corrected P >0.05).

The interaction between genotype and LER over time was highly significant (two-way mixed model, P =0.0175, n =3), as well as the interaction between genotype and division zone size over time (two-way ANOVA, P =0.021, n =3).

In addition, a marginally significant potential hotspot (E132; three mutations, p = 0.018) is located in the α-helix between two amino acid motifs (G4, NKXD and G5, EXSAK) that are important for binding the guanine base of the nucleotide 32 .

We found a nominally significant association of the stop-gain variant (T allele) with lower grip strength (additive: β =−0.062 kg, P =0.018) ( Supplementary Table 9 ) although we found no evidence for any departure from an additive genetic model at this locus ( P domdev = 0.72; Supplementary Fig. 5 ).

Bacteria of the genus Coprococcus and family Ruminococcaceae showed a trend toward an increase in abundance following naproxen treatment ( P = 0.018, P = 0.022, FDR = 0.25, 0.25; Fig. 4A, B ).

5d and Table S13 ) indicate that, among the three traits, only whole-body fat-free mass has a nominally significant causal effect on UL risk ( p = 0.018) and, thus, support the original findings.

There was a significant trend towards TR expansions versus contractions ( χ 2 = 5.46, df = 1, P = 0.019).

The full canonical model between the neural activity and the face feature space was significant in P1, P3, and P4 and approached significance in P2 (P1: Χ 2 (171)=211.33, Wilks’ λ=.021, p=.019; P2: Χ 2 (152)=181.21, Wilks’ λ=.045, p=.053; P3: Χ 2 (171)=230.93, Wilks’ λ<.001, p=.001; P4: Χ 2 (152)=194.06, Wilks’ λ=.03, p=.012) demonstrating that FFA activity is sensitive to individual differences in these facial feature dimensions.

Circulating HDL levels are reported to be associated with decreased AD risk, and we observed nominally significant and positive covariance with CSF Aβ42 (r g- =0.007, SE = 0.003, p = 1.96×10 −02 ) in our analysis, although this failed to pass the FDR-corrected significance threshold.

This single variant accounted for 76% of loss of function carriers and the CHEK2 association was nominally significant when it was excluded ( p = 0.02, effect = 0.18 SD).

All methods except Pagel’s λ detected a marginally significant phylogenetic signal in the K. pneumoniae core genome (Supplementary Data 3 [first tab]; 0.11 > P > 0.02).

After TAC, heart weight/body weight ratio varied significantly between groups, though TAC comparisons within genotype did not reach statistical significance by Bonferroni post test ( p = 0.02, ANOVA, Ppp1r3a +/+ TAC vs.

Given that several atherosclerosis risk factors have been associated with AS 6 , 18 , 19 , we tested the novel AS variants for association with the traditional cardiovascular risk factors and observed a nominally significant association ( P < 0.02) between rs1830321 and systolic and diastolic blood pressure in Iceland (Supplementary Data 3 ) and in data from the UK Biobank ( https://biobankengine.stanford.edu/search# ).

At both ages, relative improvement was noted as a result of hGPC treatment, although this effect failed to achieve significance in the older of the two R6/2 groups (36%, P <0.02; and 19%, P =0.068, respectively).

The allelic effect on CXorf21 expression was only nominally significant when performing the cis -eQTL analyses in female individuals from Geuvadis RNA-Seq dataset in LCLs ( P = 0.02; linear-regression; Supplementary Fig. 2a ).

Comparing Pk1a maximum power across genotypes revealed a strong trend supporting the bootstrapped spectrum results (Fig. 6r ; uncorrected p -value = 0.02), with no apparent difference in Pk1b maximum power (Fig. 6t ) nor the center frequency of either subpeak (Fig. 6q, s ).

We further investigated the psoriasis/CAD genetic correlation by applying LDSC to our case-control psoriasis GWAS (11,024 cases and 16,336 controls) and a large CAD GWAS (60,801 cases and 123,504 controls), which provided a nominally significant ( p = 0.02) genetic correlation ( r g = 0.11).

Accordingly, excluding area RL from the analysis revealed a decreasing trend in the trial-to-trial variability along the hierarchy in the high-frequency state ( S H : Pearson’s r with anatomical hierarchy score = -0.94, p = 0.02; S I : Pearson’s r = -0.43, p = 0.5, S L : Pearson’s r = -0.46, p = 0.4).

ACTR3_SEPEP.1_C4 was associated with the shared peptides, and it was lower in tumors compared with NATs with a marginal significance ( P = 0.02).

Specifically, GlycA showed significant inverse genetic correlation with two lung function parameters (FEV1: r g = −0.14 [95%CI: −0.19, −0.09; P = 1.01 × 10 −7 ]; FVC: r g = −0.18 [95%CI: −0.23, −0.13; P = 3.54 × 10 −14 ]) and significant positive genetic correlation with asthma (r g = 0.21 [95%CI: 0.11, 0.31; P = 1.93 × 10 −5 ]) and COPD (r g = 0.31 [95%CI: 0.16, 0.46; P = 6.04 × 10 −5 ]) after controlling for multiple testing ( P < 0.05/30), while GlycA was only marginally significant related with FEV1/FVC (r g = 0.06 [95%CI: 0.01, 0.11; P = 0.02]) and PEF (r g = −0.07 [95%CI: −0.12, −0.03; P = 2.74 × 10 −3 ]).