Barely Significant

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In the univariable and multivariable analyses, stage was an independent prognostic factor for progression-free survival, locoregional recurrence-free survival, and distant metastasis-free survival in the intention-to-treat population and the per-protocol population, marginal significance for overall survival in the intention-to-treat population (Table 2 , Supplementary Table 5 ).
These findings demonstrate a significant trend for the cOFC units recorded to be more actively involved during events related to reward processing and the initiation of trials, possibly linked to attentional and reward-evaluation processes, whereas the pACC units recorded showed greater involvement during events associated with aversive outcomes, such as the delivery of airpuffs following particular choices or cues.