Excerpts

5d , reveal an interesting trend.

The mean increase of Ca 2+ -fluorescence during lateral bending (Δ F/F 0 ), was highly significant in both CSF-c neurons ( Fig. 7f ).

pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement yes pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY A marked trend during the last decades has been the extreme miniaturization of components in information technologies aiming to produce devices with higher speed and storage capacity.

The long-lasting stimulatory effect of CNO on food intake was accompanied by an increase in body weight (note that this effect was highly significant on day 3 after CNO injection; Fig. 9d ).

The relaxation rates show a clear trend: Since photoconductivity data demonstrate a substantial charge transfer from nano-Au to PZT, with the highest efficiency in ITO/nano-Au/PZT ( Fig. 3c ), we suggest that the nano-Au−PZT charge transfer may be responsible for speeding up the relaxation of the high-frequency spectral component in nano-Au/PZT hybrids.

Overall, we only observed a marginally significant overlap between our cerebellar aging gene set and those related to cognitive decline and dementia in the HRS.

Extracting the activation energies for the different devices by the procedure(s) described yields a clear trend (see Supplementary Figs 3 and 6 ).

The genotype and phenotype associations were highly significant in the higher education stratum (main genetic effects, 1.97 × 10 −10 ≤ P main ≤8.16 × 10 −8 ) but were considerably weaker in the lower education stratum (0.008≤ P main ≤0.243).

Two SNP × education interactions were nominally significant ( Supplementary Table 6 ): TJP2 in Europeans (rs11145488, P int =6.91 × 10 −3 ) and SHISA6-DNAH9 in Asians (rs2969180, P int =4.02 × 10 −3 ).

As a population at carrying capacity can be considered to have gone through a critical transition when the realized non-linear growth rate of a population falls below one (and thus the ability of a system to respond to perturbations diminishes) 11 , in the above scenario a negative trend in the mean body size of a population (and consequently in growth rates) could be used as an alternative measure of whether a system is approaching a bifurcation.

Rather, we argue that one would expect a consistently declining trend before collapse in the mean body size, and, potentially, an increasing trend in the variance of body size.

For platelet-lineage gene expression, we observed a highly significant, age-dependent increase in the frequency of expression, not only in Vwf + HSCs but also in Vwf − HSCs ( Fig. 2c,e ; Supplementary Fig. 3b ), with the majority of platelet-lineage genes being more highly expressed in Vwf + and Vwf − -aged HSCs ( Supplementary Fig. 5 ).

This highly significant reduction—over 90%—suggests that w Anga may interfere with Plasmodium development in the mosquito vector, as shown in artificial Anopheles – Wolbachia combinations 14 15 19 .

We restricted this analysis to genes with Class 1 nominally significant T1 P -values in the Discovery series.

Saturation was also reached sooner in reads from larger-insert libraries, with a clear trend towards decreasing transcript diversity with increasing insert length, except that the 1–2 kb library was more diverse than the 0–1 kb library ( Supplementary Fig. 10b ).

There is a clear trend; as the nucleotide specificity box motif becomes more negatively charged and polar, there is an increased preference for cytosine bases.

5 , the absorption peak of the carbonyl group of aldehyde 2a at 1703, cm −1 was monitored during the progress of the catalytic cyanosilylation and an interesting trend was observed.

Of the 32 cases of significant changes in diversity that we detected, 28 corresponded to significant clonal expansions/contractions, the 4 others being borderline significant for clonal expansions/contractions.

While the exact mechanism by which these transcriptional hubs may function is yet unknown, our data demonstrate that subsets of genes, spanning entire chromosomes, can physically associate with the same enhancer, and that a highly significant portion of those genes are coexpressed within the cell.

Mice given the lower dose of rGDF11 (0.1 mg kg −1 ) also showed a trend of decreased trabecular bone volume, although it was not statistically significant ( P =0.078).

While the highly significant association between free soluble anti-rhIL-2 autoantibodies and T1D is remarkable, the functional capacity of these antibodies—at the monoclonal level—to neutralize or otherwise modulate IL-2 function remains to be assessed.

Among the selected targets, Thy1 (LTR/Gypsy), Parp4 (LTR/Gypsy) and Hel1 (RC/Helitron) all showed a trend of reduced expression with the progression of development.

This list was then curated based upon a set of criteria demanding the gene must be highly significant controlling for false discovery rate ( q <0.05), and differentially regulated at a fold change >2 0.5 ( Supplementary Fig. 3 ).

Importantly, LCN13 expression studies in this patient cohort revealed a highly significant correlation between Tsc22d4 and Lcn13 mRNA levels ( Supplementary Fig. 6a ), and demonstrated an overall lower expression of LCN13 in diabetic patients as compared with non-diabetic subjects ( Supplementary Fig. 6b ).

Although maximum-likelihood trees of repeats in each protein are not highly reliable due to the small size of the repeats, analysis of such trees across the proteome reveals a highly significant positive correlation between the physical and evolutionary distances, whereas a significant negative correlation is rarely observed ( Fig. 3c ).