Excerpts

After conducting GWAS on the 4505 isolates with associated azithromycin MICs, we identified highly significant unitigs (i.e., genetic variants generated from de novo assemblies) mapping to the 23S rRNA, associated with increased resistance, and to the efflux pump gene mtrC , associated with increased susceptibility and cervical infections 7 .

Additionally, the association for the MEPE LoF variant remains highly significant when conditioning for the lead variant of the eBMD analysis (effect size conditional = −0.529 SD, P -value conditional = 5.3 × 10 −18 ).

RNA recovery within the whole droplet showed an increasing trend as the water was lost from the coacervate mixture (Fig. 3e ).

For example, the combination of ruxolitinib with capecitabine showed a trend of improved survival in patients with metastatic pancreatic cancer and evidence of systemic inflammation 92 .

A clear trend from more negative values in the top right to less negative values in the bottom left can be discerned for K int .

This was highly significant when compared to the overlap of randomized gene sets of the same number as the number of MPP8-repressed genes (Fig. 5d ).

Within the ATX group, we observed a positive trend between the pupil dilation response and the neural spread of association in parahippocampus-hippocampus (Fig. 6f ).

) To enter the domain of applied significance, electroreduction of N 2 should generate ammonia at a practically significant rate.

Patients with high tumor SMARCA2 (BRM) protein expression showed a trend towards a better overall survival, although this relationship did not reach statistical significance.

Thus, the aforementioned existence of signature metabolites for each group of tea accessions collected from diverse locations and environments is quite significant, as it suggests that these signature metabolites are predominantly determined by genetic factors.

In addition, we identified a nominally significant enrichment for microglia/astrocyte OCRs in Alzheimer’s disease, which is consistent with a recent study implicating microglia enhancers in Alzheimer’s disease 38 The cell-specific map of chromatin accessibility generated in this study can be used to deconvolute bulk tissue ATAC-seq data from the human brain cortex.

Lower healthy tissue uptake (toxicity) with loading dose When the total antibody dose increased from 0.3 mg kg −1 to 2.6 mg kg −1 , muscle uptake of the antibody–dye conjugate (%ID kg −1 ) showed a decreasing trend (Fig. 2a ), suggesting that co-administration of unlabeled antibody saturates the estimated glomerular filtration rate (EGFR)-binding sites in the muscle and thus reduces the target-mediated uptake (relevant for ADC toxicity) in healthy tissue.

Measurements of major short-chain fatty acids (SCFAs) in the cecum and colon showed a trend of incremental increases of absolute and relative butyrate levels as AcGGM levels were increased (Fig. 2 ).

In our study, we found a highly significant increase in both infection rate and number of symptoms when people attended carnival festivities, as compared to people who did not celebrate carnival.

Species showing a significant or marginally significant shift according to K-S test were the same that showed a significant difference between deciles.

Indeed, transcriptional strand bias in XP-C was strong and highly significant for all six classes of nucleotide substitutions grouped by the reference and mutated nucleotide, while in tissue-matched sporadic cancers it was weak or absent (Fig. 3a−c, e and Supplementary Fig. 3a−c ).

qRT-PCR analysis confirmed the very large, highly significant increase in Gm15441 expression and its complete inhibition in Ppara −/− liver (Fig. 2c ).

This trend had marginal significance, changing with different parameters used for analysis.

Remarkably, we found a highly significant enrichment of the differentially expressed genes in GLP cKO (Fig. 5i ) and G9a cKO (Supplementary Fig.

The bird-only and mammal-only models also supported the findings, although the relationship between pace of life and migratory strategy was only marginally significant for mammals; this weaker association in mammals was likely driven by swimmers (see above, Supporting Information S4 ).

In fact, sporadic human cases caused by H7N9, H5N6, and H9N2 continue to be reported 5 , 57 , and the seroprevalence rate of H9N2 AIVs in the poultry workers posed an increasing trend after 2009 in China 7 , 58 .

After a 5-min SP test, however, we observed a significant (or almost significant) increase of c-Fos induction specifically in the MeA and NAc shell, but not in the LSD, LSV, or NAc core (Supplementary Fig. 8 ; one-way ANOVA, LSV— F 2,12 = 0.847, p = 0.453; LSD— F 2,12 = 2.327, p = 0.140; NAc core— F 2,12 = 0.444, p = 0.652; NAc shell— F 2,12 = 3.767, p = 0.057; MeA— F 2,12 = 7.161, p = 0.009).

A ISW1a-dinucleosome model was constructed based on these data, but has not been validated during the last nine years, even though it would be highly significant as thus far no other ATP-dependent chromatin remodeler is known to act specifically on dinucleosomes.

Indeed, the pronounced focal accumulation of UHRF1-GFP observed in Dppa3KO and T12CM ESCs corresponded with a highly significant increase in the CV values of nuclear UHRF1-GFP compared with wt ESCs (Supplementary Fig. 4i, j ).

To this end, we focused on genes that were (i) significantly associated with high levels of THBD or NCR1 (fold change > 2 or < −2, and Q or P value < 0.05) from Nanostring data, (ii) with highly significant prognostic value (HR < 1 or >1), and (iii) predominantly expressed by DCs and/or NK cells.