Barely Significant

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Inter-residue H-bonds between non-adjacent backbone amide NH and C=O motifs lead to the well-known secondary structures of helices, turns and sheets, but it is recognized that other H-bonding modes may be significant, including the weak intra-residue H-bond (called a C5 H-bond) that implicates the NH and C=O motifs of the same amino acid residue.
In contrast to the CTX group, the five differential metabolites of gentisate aldehyde, 4-hydroxy-2-oxoglutaric acid, D-sorbitol, galactitol, and L-proline displayed an increasing trend in immunoregulation, while the remaining ten metabolites showed a decreasing trend.