The treatments showed a trend of improved blood glucose concentration at 120 min during 75 g OGTT (148.8 ± 21.1 vs. 142.9 ± 19.1 mg/dL; p = 0.23) and resulted in a significant increase of normal glucose tolerance (NGT) response in PA patients ( n = 13, from 23% to 38%) ( p = 0.0004, Chi-square test) ( Figure 7 A,B).
However, this finding reached only borderline significance ( p = 0.2315).
A nonsignificant trend favoring UST in the clinical response rate (52% vs. 25%, p < 0.24) and the clinical remission rate (25% vs. 27%, p < 0.82) was observed, as expected, in the subgroup of anti-TNFα–experienced patients [ 22 ].
On the contrary, Figure 3 B shows that natural killer lymphocytes ( p = 0.131), natural killer lymphocyte granzyme + ( p = 0.521), T cytotoxic lymphocyte granzyme + ( p = 0.760), T natural killer lymphocytes ( p = 0.131), total plasma cells ( p = 0.822) and Ab-secreting plasma cells ( p = 0.497) did not have a significant trend among the four groups, nor did the number of days to negative nasopharyngeal swab ( p = 0.241).
In the high-cytogenetic-risk group, although there was a clear trend favoring group 1, the OS difference was not statistically significant—1068 days for group 1, compared to 693 days in group 2 ( p = 0.246) ( Figure 10 ).
Female sex showed a nonsignificant trend toward an increased risk (OR: 1.47, 95% CI: 0.76–2.84, p = 0.250).
Of note, our study showed a small trend towards renal protection (acute kidney injury: n = 1 RIPC group vs. n = 4 control group, p = 0.250), but this was not statistically significant.
Survivors in our study showed a trend for shorter reperfusion times (minutes: 83.3 ± 40.6 vs. 98.4 ± 40.5; p = 0.25) and total CBP times (minutes: 215.8 ± 73.6 vs. 256.2 ± 125.9; p = 0.26) with a significantly shorter total operation time (minutes: 364.6 ± 97.1 vs. 449.1 ± 141.7; p = 0.002).
A sensitivity analysis excluding Tamene et al.’s study [ 9 ] showed a trend reversal, favoring lower-educated workers, with an RR of 0.47 (95% CI: 0.29–0.77, p = 0.2562; I 2 = 26.6%).
The unmatched analysis showed a trend toward higher 30- and 90-d mortality in the FFP group (30 d: +7% p = 0.261; 90 d: +11.9% p = 0.061).
Even if transaminases (AST) and lactate-dehydrogenase (LDH) showed a trend toward increase, this was not significant ( p = 0.358).
In the present study, we analysed CD36 by IHC in TMAs from tumour specimens obtained during cystectomy and found that CD36 immunopositivity was significantly associated with greater depth of tumour invasion (pT3b-pT4 stage) and showed a trend toward association with greater lymph node involvement (pN stage) ( p = 0.391), both of which are well-known markers of poor prognosis in MIBC [ 38 ].
Both the groups with tinnitus and sensorineural hearing loss, as well as the tinnitus-only group, showed a trend indicating that higher serum sodium levels were associated with greater tinnitus intensities ( p = 0.43 and p = 0.62, respectively).
As shown in Figure 2 a, plasma Aβ 1-40 levels showed a decreasing trend in patients exhibiting decrease of cognitive function (r = 0.438, p = 0.46).
TRF interventions showed null effects for HDL-c (k = 8, 0.00 (95% CI [−0.60, 0.61]), p = 0.99), and a positive trend to reduce the LDL-c (k = 7, 4.48 (95% CI [−7.60, 16.56]), p = 0.47), total cholesterol (k = 8, 8.14 (95% CI [−8.37, 24.65]), p = 0.33) and triglycerides (k = 9, 8.93 (95% CI [−1.58, 19.45]), p = 0.10) levels ( Table 3 ; Figure 3 ).
Second, only SNPs with a statistically marginally significant association with risk of ischemic stroke ( p <0.5) in any one of the additives (per-allele), dominant or recessive logistic regression models were included.
For semaglutide, pooled data from three studies, including patients with HFrEF, suggested a marginally significant benefit for HFH and CV mortality (RR: 0.83, 95% CI: 0.69–1.00; Cochran’s Q test, p = 0.51; I 2 = 0%) [ 23 , 24 , 25 ].
Patients after nRCT showed a trend towards a more frequent change in the treatment modality to stent therapy (nCT n = 4 (30.77%) vs. nRCT n = 7 (53.85%) p = 0.518); this was, however, not statistically significant ( Figure 1 ).
There was a nonsignificant trend toward a lower miscarriage rate in freeze-all ET (8.9% vs. 11.6%; p = 0.549).
Clinically significant changes in pitch (ΔSFF ≥ 12) after surgery were evident in seven (15.91%) patients in the transoral group and eight (21.05%) patients in the open group; no significant between-group difference was apparent (p = 0.579) ( Figure 2 ). 4.
The level of stress showed a trend towards a decrease in both groups between baseline and 12-month measurements (U = 602.5, p = 0.602) ( Table 2 ).
Using mixed models, we did not find a significant trend over time for hemoglobin levels ( p = 0.61) or ferritin levels ( p = 0.36), and no difference in evolution between groups was observed ( p = 0.59 for hemoglobin and 0.60 for ferritin). 3.3.
There was a decrease in NPS ratings of pain severity from pre- to post-intervention that approached significance (mean PDI PRE Intervention: 19 ± 10; mean PDI POST Intervention ± SD POST Intervention: 21 ± 20; t = −0.486, df = 6, p = 0.644; mean Pain Interference PRE Intervention: 2.1 ± 2.3; mean Pain Interference POST Intervention ± SD POST Intervention: 0.6 ± 0.8; t = 3.161, df = 6, p = 0.052).
As in univariate analysis, PCR negative patients, showed a trend towards higher all-cause mortality and readmission (HR 1.11, 95% CI 0.80–1.53, p < 0.66) ( Table 2 ), as well as increased all-cause mortality (HR 2.41, 95% CI 1.40–4.15, p < 0.01) as compared to patients without flu-like symptoms.
For EQ-5D, both the time effect ( p = 0.056) and between-group effect ( p = 0.059) approached but did not reach significance, with no significant interaction ( p = 0.754).