Barely Significant

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Valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) has emerged in recent years as a novel alternative approach to conventional Redo surgical aortic valve replacement (Redo-SAVR) resulting in an increasing trend toward implantation of biological valves at primary surgical aortic valve replacement (SAVR), even in younger patients.
The first interim analysis, at a median follow-up of 17.9 months, showed a statistically significant improvement in PFS (24-month PFS was 67.8% with pembrolizumab + CCRT versus 57.3% with placebo + CCRT) and a favorable trend in OS (HR = 0.73) for the combination pembrolizumab and CCRT compared with placebo and CCRT, with a manageable safety profile.
compared local quadrantic injection of 40 mg of triamcinolone after EBD of short ileocolic anastomotic CD strictures (<5 cm) to saline placebo [ 23 ]; 1 in 6 patients in the placebo group required redilation compared to 5 in 7 in the steroid group, with a statistical trend towards a difference in time to repeat dilation, which was worse in the steroid group ( p 0.06, HR 6.1).