Barely Significant

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When categorized into three groups according to the tertile of baseline serum NGAL (NGAL tertiles, 1st: 25.4 to 83.7 ng/mL, 2nd: 83.8 to 143.8 ng/mL, 3rd: 143.9 to 567.9 ng/mL), there was a significant trend toward higher serum NGAL levels with older age, hypertension, diabetes, chronic kidney disease, low ejection fraction, high C-reactive protein, higher contrast volume, multivessel coronary disease, larger number of stents, and longer stent length.
Results of a meta-analysis that included 18 randomized clinical trials (RCTs) with more than 4000 OSA patients on CPAP therapy did not show a significant decrease of cardiovascular event risk compared with the control group but only a nonsignificant trend of lower rate of death and stroke [ 37 ].
There was a clear trend—from the aorto-iliac towards only infrapopliteal segments—in increasing prevalence of diabetes (28.3% vs. 60.0%), heart failure (5.4% vs. 15.8%), renal failure (16.6% vs. 49.5%), polyneuropathy (4.6% vs. 17.9%) and CLTI stage of LEAD (8.6% vs. 74.0%).