“indeterminate significance”

In turn, the recruitment of RNA in the aggregates has often been regarded as a secondary step of indeterminate significance.

The significance of these restrictions can be understood by considering clinically-impactful categories of lymph node metastases, including those that are greater than 0.2 cm (significant), micrometastases between 0.02 to 0.2 cm (indeterminate significance), and isolated tumor cells less than 0.02 cm (low significance) 1 , 3 .

Hence, the number of mutations considered of unknown or indeterminate significance was high.

Two patients from cohort 2 harbored PTEN mutations of indeterminate significance and were excluded from the overall survival (OS) and progression-free survival (PFS) evaluations.

After a while it becomes necessary for him to take refuge in the no man’s land of “dysplasia” and other “entities of unknown or indeterminate significance” and, compiling data for “predicting outcome,” he becomes something like a haruspex, this diviner of antiquity whose function was to predict, for the benefit of the Emperor (the clinician), the issue of a battle by reading in the viscerae of a sacrificed animal (the patient) ( Figure 1 ).

Experts spoke of overdiagnosis as being of indeterminate significance because of uncertainty about the overdiagnosis rate.

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Furthermore, with the current literature showing a high signal of post-CAR-T MDS, particularly for patients who enter CAR-T with underlying clonal hematopoiesis [ 124 , 125 ], as well as prolonged cytopenias [ 126 , 127 ], alloSCT has the potential benefit of curing both the lymphoma and underlying clonal hematopoiesis of indeterminate significance (CHIP).

Within the measurement error of mSASSS, that scores of 1 is intermediate, and perhaps of indeterminate significance.

Although of indeterminate significance, WNV has been detected in ticks (Hyalomma marginatum marginatum nymph) [ 16 ].

Interestingly, the inherited bone marrow failure molecular panel detected a heterozygous SAMD9 variant of indeterminate significance.

In a second case suffering from PPHCD [ 3 ], a standardized SPARK Inherited Retinal Dystrophy (IRD) panel was performed testing several mutations of indeterminate significance across multiple genes, including CCD2D2A, CEP78, NR2E3, PCARE, PEX14, and RPGRIP1.

In the abnormal squamous cell category the distribution of lesions was as follows: Atypical squamous cells of indeterminate significance (ASC-US) were 7.1%; atypical squamous cells, cannot exclude high squamous intraepithelial lesion (ASC-H) were 1.08%; low grade squamous intraepithelial lesion (LSIL) including human papillomavirus was 2.2%, high grade squamous intraepithelial lesion (HSIL) was 0.8% and high grade squamous intraepithelial lesion with suspicious invasion was 0.06% smears.

D2‐40 (podoplanin) highlighted a subset of the spindled cells, with absent staining within the rounded nodules of indeterminate significance.

It should have a high negative predictive value for cytologic samples of indeterminate significance.

The Afirma Gene Expression Classifier assists in decision making regarding surgical recommendations for aspirates with cytology of indeterminate significance or follicular lesions [ 12 , 56 ].

(0 and 1 were collapsed since 1 represents signal hyperintensity on T2-weighted images of indeterminate significance.) Subchondral sclerosis was scored at baseline from 0 to 3 for each region of the knee as: 0: none, 1: <25% of the subregion, 2: 25–50% of the subregion, 3: >50% of the subregion.

In certain cases, HE does not lead to organic impairments, being termed indeterminate significance HE or simply HE, which requires no treatment; only clinical follow-up is needed.

This renders the fine-needle aspirates (FNA) of thyroid follicular nodules useless for diagnostic purposes and biopsies not allowing for determination of the lesions malignant potential are determined as of indeterminate significance [ 5 ].

These cytological diagnoses are determined, as follows: 1) Bethesda I, nondiagnostic or unsatisfactory, 2) Bethesda II, benign, 3) Bethesda III, atypical of indeterminate significance or follicular lesion of indeterminate significance, 4) Bethesda IV, follicular neoplasm or suspicious for a follicular neoplasm, 5) Bethesda V, suspicious for malignancy, and 6) Bethesda VI, malignant.

A potential pathogenic connection with the prior viral infection may be suspected, yet of indeterminate significance at this point [ 42 , 43 ].

Introduction In the continuous spectrum of monoclonal gammopathies, smoldering multiple myeloma (SMM) occupies an intermediate position between what is usually referred to as a pre-malignant condition, i.e., monoclonal gammopathy of indeterminate significance (MGUS) and active multiple myeloma.

The term clonal hematopoiesis of indeterminate significance (CHIP) was introduced to describe individuals with a hematologic malignancy-associated somatic mutation in peripheral blood or bone marrow cells but without any other diagnostic criteria for a hematologic malignancy. 107 CHIP must be distinguished from myelodysplastic syndromes (MDS) by the absence

It is important to have baseline comprehensive tumor based genetic testing to avoid erroneous diagnoses from clonal hematopoiesis of indeterminate significance.

In the study by Deandrea et al., the smears diagnosed as follicular lesions of indeterminate significance and follicular neoplasm had a RoM of 4.95% and 25% each.