The log-rank (Mantel–Cox) test was found to be approximating significance ( P = .053).
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“approximating significance”
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p=0.09
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At the end of the experiment (day 57), all mice receiving a single drug treatment had measurable tumors, and a similar tumor volume inhibition (TVI) (43%) was achieved in both groups barely approximating significance ( p = 0.059 trametinib, p = 0.053 pazopanib).
This observation demonstrates that the principled way of hierarchically approximating significance for groups of loci adds value to the exploitation of genomic redundancies.
However, none of the correlations with the ADOS-2 scores or with ADI-R at the 10- and 14-month visits were approximating significance ( Supplemental material Table S3 ).
As for OS, 320 GA patients had OS information, and the overall hazard ratio (HR) was 0.638 (95% confidence interval [CI]: 0.401–1.013, p = 0.057), approximating significance.
Multivariate analysis showed approximating significance with p = 0.05. 3.4.
Approximating significance via permutation, we identify sets with significantly high pathway centrality as functional mediating pathways.