Excerpts

Recently, in a large REDUCED-IT trial ( n = 8179), authors demonstrated that the administration of icosapent ethyl, 4 g daily in patients at elevated risk for cardiovascular disease who have increased baseline TG, but well-controlled LDL-C levels, have highly significant clinical benefit and reduced incident events, including cardiovascular death over and above statin therapy [ 19 ].

After adjusting the baseline value, lactate levels revealed a borderline significant trend for the p -value, and the statistical significances of differences in other parameters were similar to those identified on post hoc analysis ( Table 4 ).

All statistical tests were two-tailed, and p < 0.05 was considered indicative of statistical significance; moreover, 0.05 ≤ p < 0.1 was considered to represent a trend toward significance to increase the sensitivity for the detection of potential selection biases. 3.

Out of the previously described P2 wave amplitude correlations, only the one with tacrolimus trough level was universal, although it was of borderline significance in both subgroups, whereas others were present only in the Prograf subgroup. 3.5.

Here, we only found slightly significant associations (BMI-adjusted) between the pGRS and certain lipid metabolism outcomes ( Table 2 ; Table 3 , and Supplementary Table S8 ), none of them passing multiple-test adjustment.

Although not significant, CV death showed a trend toward a higher rate in the PCI group.

A numerical trend toward a higher proportion of patients without radiographic progression in mTSS (SDC criteria) was observed at Years 1 and 2 in favor of the no-GC subgroup.

MET FISH analysis showed no benefit of onartuzumab, while EGFR -mutated patients showed a trend toward short OS when treated with onartuzumab (HR: 4.68; 95% CI: 0.97–22.63).

There is a slight trend to a higher involvement for spouse’s in the young couples cluster compared to the clusters of mature and retired couples, but this difference was not significant. 4.

Still, a small trend can be elicited if the studies are sub-grouped, as shown in Supplementary Data 1 (S1) .

Introduction Sjögren’s syndrome (SS) is a complex and heterogeneous disorder that follows a strong trend of female predilection observed in many autoimmune diseases, ranking second after autoimmune thyroiditis [ 1 ].

Given the highly significant association between axial length and para-foveal vascular density, this region was further divided into nasal, temporal, superior and inferior divisions for analysis.

Furthermore, by analyzing the influence of intellectual functioning, results demonstrated a favorable trend of reduction of severity of illness and amelioration of global functioning associated with higher IQ.

Eight of the 14 were developed in the last five years, suggesting an increasing trend or recognition of importance.

aeruginosa isolated in their sputum at exacerbation showed a trend for higher IL-17a levels on day 1, reaching statistical significance from day 5 until day 60.

The MES -VAT of patients with active CD also showed a trend for an increase in the abundance of the genus Streptococcus compared with the MES -VAT of patients with inactive CD.

Contrary to what was expected, in our NMA, the SMD in FVC at 12 months between cyclophosphamide and the placebo, although showing a positive trend in favor of cyclophosphamide (SMD = 0.08), did not reach statistical significance (95% CI, −0.22 to 0.38).

The results for the secondary endpoints showed a favorable trend of therapeutic hypothermia for an anticonvulsant effect.

In both females (τ = −0.05; p = 0.05) and males (τ = −0.05; p = 0.06), there was a weak correlation between platelet count and age, but with marginal significance.

Interestingly, a highly significant decrease in insulin levels primarily contributed to this reduction of HOMA-IR, whereas FG levels did not significantly change over time.

These odds showed an increasing trend for each additional symptom reported, with the highest value of OR (almost 10) reached for six symptoms.

Although increasing levels of cGMP is likely to have many effects for improving heart failure, the effects on phosphorylation of the titin N2Bus element is likely to be significant.

There were no significant differences between the subgroups (Q test = 3.46; p -value = 0.063) although its value was very close to significance. 3.5.

However, a clear trend to higher thicknesses was found in the ASD group, at all macular subfields and at inferior peripapillary sectors, with such differences as over 10 microns at the macular central subfield ( Figure 6 ), over 13 and 10 microns at clock-hour 6 and 5 sectors, respectively ( Figure 7 ), and over eight microns at inferior peripapillary quadrant ( Figure 8 ).

However, we observed a highly significant negative correlation between age and RPE thickness in some central cells which, to our knowledge, has not been reported before.